8,822 research outputs found
Functionalized MoS2 nanosheet-capped periodic mesoporous organosilicas as a multifunctional platform for synergistic targeted chemo-photothermal therapy
The combination of different therapies into a single platform has attracted increasing attention as a potential synergistic tumor treatment. Herein, the fabrication of a novel folate targeted system for chemo-photothermal therapy by using thioether-bridged periodic mesoporous organosilica nanoparticles (PMOs) as a drug-loading vehicle is described. The novel targeted molecular bovine serum albumin-folic acid-modified MoS2 sheets (MoS2-PEI-BSA-FA) were successfully synthesized and characterized, and then utilized as a capping agent to block PMOs to control the drug release and to investigate their potential in near-infrared photothermal therapy. The resulting PMOsâDOX@MoS2âPEI-BSA-FA complexes had a uniform diameter (196 nm); high DOX loading capacity (185 mg/g PMOs-SH); excellent photothermal transformation ability; and good biocompatibility in physiological conditions. The PMOsâDOX@MoS2âPEI-BSA-FA exhibited pH-dependence and near infrared (NIR) laser irradiation-triggered DOX release. In vitro experimental results confirmed that the material exhibits excellent photothermal transfer ability, outstanding tumor killing efficiency and specificity to target tumor cells via an FA-receptor-mediated endocytosis process. The in vivo experiments further demonstrated that the platform for synergistic chemo-photothermal therapy could significantly inhibit tumor growth, which is superior to any monotherapy. Meanwhile, cytotoxicity assays and histological assessments show that the engineered PMOs@MoS2âPEI-BSA-FA have good biocompatibility, further inspiring potential biomedical applications. Overall, this work describes an excellent drug delivery system for chemo-photothermal synergistic targeted therapy having good drug release properties, which have great potential in cancer therapy
Electronic Tuning of Mixed QuinoidalâAromatic Conjugated Polyelectrolytes: Direct Ionic Substitution on Polymer MainâChains
The synthesis of conjugated polymers with ionic substituents directly bound to their main chain repeat units is a strategy for generating strongly electron-accepting conjugated polyelectrolytes, as demonstrated through the synthesis of a series of ionic azaquinodimethane (iAQM) compounds. The introduction of cationic substituents onto the quinoidal para-azaquinodimethane (AQM) core gives rise to a strongly electron-accepting building block, which can be employed in the synthesis of ionic small molecules and conjugated polyelectrolytes (CPEs). Electrochemical measurements alongside theoretical calculations indicate notably low-lying LUMO values for the iAQMs. The optical band gaps measured for these compounds are highly tunable based on structure, ranging from 2.30â
eV in small molecules down to 1.22â
eV in polymers. The iAQM small molecules and CPEs showcase the band gap reduction effects of combining the donor-acceptor strategy with the bond-length alternation reduction strategy. As a demonstration of their utility, the iAQM CPEs so generated were used as active agents in photothermal therapy
Colloidal Plasmonic Titanium Nitride Nanoparticles: Properties and Applications
Optical properties of colloidal plasmonic titanium nitride nanoparticles are
examined with an eye on their photothermal via transmission electron microscopy
and optical transmittance measurements. Single crystal titanium nitride cubic
nanoparticles with an average size of 50 nm exhibit plasmon resonance in the
biological transparency window. With dimensions optimized for efficient
cellular uptake, the nanoparticles demonstrate a high photothermal conversion
efficiency. A self-passivating native oxide at the surface of the nanoparticles
provides an additional degree of freedom for surface functionalization.Comment: 17 pages, 4 figures, 1 abstract figur
Layer-By-Layer Assembly of Graphene Oxide on Thermosensitive Liposomes for Photo-Chemotherapy
Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO) and graphene oxide conjugated poly (l-lysine) (GO-PLL) deposited on cationic liposomesencapsulating doxorubicin. Various concentrations of GO and GO-PLL were examined and the optimal LBL Lipo-graph was found to have a particle size of 267.9âŻÂ±âŻ13âŻnm, zeta potentialof +43.9âŻÂ±âŻ6.9âŻmV and encapsulation efficiency of 86.4âŻÂ±âŻ4.7%. The morphology of LBL Lipo-graph was examined by cryogenic-transmission electron microscopy (Cryo-TEM), atomic force microcopy (AFM) and scanning electron microscopy (SEM). The buildup of LBL Lipo-graph was confirmed via ultraviolet-visible (UVâVis) spectrophotometry, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. Infra-red (IR) response suggests that four layers are sufficient to induce a gel-to-liquid phase transition in response to near infra-red (NIR) laser irradiation. Light-matter interaction of LBL Lipo-graph was studied by calculating the absorption cross section in the frequency domain by utilizing Fourier analysis. Drug release assay indicates that the LBL Lipo-graph releases much faster in an acidic environment than a liposome control. A cytotoxicity assay was conducted to prove the efficacy of LBL Lipo-graph to destroy MD-MB-231 cells in response to NIR laser emission. Also, image stream flow cytometry and two photon microcopy provide supportive data for the potential application of LBL Lipo-graph for photothermal therapy. Study results suggest the novel dual-sensitive nanoparticles allow intracellular doxorubin delivery and respond to either acidic environments or NIR excitation. Statement of Significance Stimuli sensitive hybrid nanoparticles have been synthesized using a layer-by-layer technique and demonstrated for dual chemo-photothermal destruction of breast cancer cells. The hybrid nanoparticles are composed of alternating layers of graphene oxide and graphene oxide conjugated poly-l-lysine coating the surface of a thermosensitive cationic liposome containing doxorubicin as a core. Data suggests that the hybrid nanoparticles may offer many advantages for chemo-photothermal therapy. Advantages include a decrease of the initial burst release which may result in the reduction in systemic toxicity, increase in pH responsivity around the tumor environment and improved NIR light absorption
Colloidal CuFeS2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency
We describe the colloidal hot-injection synthesis of phase-pure nanocrystals
(NCs) of a highly abundant mineral, chalcopyrite (CuFeS2). Absorption bands
centered at around 480 and 950 nm, spanning almost the entire visible and near
infrared regions, encompass their optical extinction characteristics. These
peaks are ascribable to electronic transitions from the valence band (VB) to
the empty intermediate band (IB), located in the fundamental gap and mainly
composed of Fe 3d orbitals. Laser-irradiation (at 808 nm) of an aqueous
suspension of CuFeS2 NCs exhibited significant heating, with a photothermal
conversion efficiency of 49%. Such efficient heating is ascribable to the
carrier relaxation within the broad IB band (owing to the indirect VB-IB gap),
as corroborated by transient absorption measurements. The intense absorption
and high photothermal transduction efficiency (PTE) of these NCs in the
so-called biological window (650-900 nm) makes them suitable for photothermal
therapy as demonstrated by tumor cell annihilation upon laser irradiation. The
otherwise harmless nature of these NCs in dark conditions was confirmed by in
vitro toxicity tests on two different cell lines. The presence of the deep Fe
levels constituting the IB is the origin of such enhanced PTE, which can be
used to design other high performing NC photothermal agents.Comment: 12 pages, Chemistry of Materials, 31-May-201
Broadband converging plasmon resonance at a conical nanotip
We propose an analytical theory which predicts that Converging
Plasmon Resonance (CPR) at conical nanotips exhibits a red-shifted and
continuous band of resonant frequencies and suggests potential application
of conical nanotips in various fields, such as plasmonic solar cells,
photothermal therapy, tip-enhanced Raman and other spectroscopies. The
CPR modes exhibit superior confinement and ten times broader scattering
bandwidth over the entire solar spectrum than smooth nano-structures. The
theory also explicitly connects the optimal angles and resonant optical
frequencies to the material permittivities, with a specific optimum half
angle that depends only on the real permittivity for high-permittivity and
low-loss materials
Local generation of hydrogen for enhanced photothermal therapy.
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here we utilize the cubic PdH0.2 nanocrystals for tumour-targeted and photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer. The synthesized PdH0.2 nanocrystals have exhibited high intratumoural accumulation capability, clear NIR-controlled hydrogen release behaviours, NIR-enhanced self-catalysis bio-reductivity, high NIR-photothermal effect and PAI performance. With these unique properties of PdH0.2 nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat. This hydrogenothermal approach has presented a cancer-selective strategy for synergistic cancer treatment
A Review on the Scope of Photothermal TherapyâBased Nanomedicines in Preclinical Models of Colorectal Cancer
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multifunctionality, with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapyâbased nanomedicines in colorectal cancers. This review presents the current scope of preclinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications
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Synthesis of molybdenum oxide nanoparticles by nanosecond laser ablation
Phothermal therapy (PTT) is one of the most promising techniques to treat cancer. Finding the ideal PTT agent nanomaterial has remained a challenge and has brought the interest of several researchers. In this work, we report the synthesis of molybdenum oxide (MoOx) nanoparticles (NPs), which exhibit absorption in the biological optical window ~840 nm, by using the laser ablation of solids in liquids (LASL) technique with nanosecond (ns) pulses. A Nd:YAG laser was used to synthesize the NPs in deionized (DI) water, free of surfactants or additives, which were optically characterized by absorption spectroscopy and TEM-EDX microscopy. Semi spherical NPs with a suitable average size and shape for potential use as PTT agents were obtained by laser ablation and ablation + fragmentation. The calculated band gap is 3.1 eV, which corresponds to MoO3. Micro-Raman spectroscopy studies determined that these NPs are composed of amorphous molybdenum oxide hydrates (MoO3 · xH2O)
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