Departure from the onset-onset rule

Using a signal-detection task, the generality of Turvey's (1973) onset-onset rule was tested in four experiments. After seeing, in succession, (1) one or two letters (target display), (2) a multiletter detection display, and (3) a mask display, subjects decided whether or not the letter or letters in the target display reappeared in the succeeding detection display at different levels of detection-display duration in various situations. The subjects' sensitivity was inconsistent with the onset-onset rule. More specifically, sensitivity increased with increases in display duration within a fixed stimulus onset asynchrony of 150 msec. Display duration, however, had no effect on response bias. Nor was there any interaction between display duration and display size in terms of either sensitivity or response bias. The more complicated relationship between display duration and display size does not invalidate the departure from the onset-onset rule

Generalized synchronization onset

The behavior of two unidirectionally coupled chaotic oscillators near the generalized synchronization onset has been considered. The character of the boundaries of the generalized synchronization regime has been explained by means of the modified systemComment: 7 pages, 3 figure

Onset of entanglement

We have developed a theory of polymer entanglement using an extended Cahn-Hilliard functional, with two extra terms. One is a nonlocal attractive term, operating over mesoscales, which is interpreted as giving rise to entanglement, and the other a local repulsive term indicative of excluded volume interactions. We show how such a functional can be derived using notions from gauge theory. We go beyond the Gaussian approximation, to the one-loop level, to show that the system exhibits a crossover to a state of entanglement as the average chain length between points of entanglement decreases. This crossover is marked by critical slowing down, as the effective diffusion constant goes to zero. We have also computed the tensile modulus of the system, and we find a corresponding crossover to a regime of high modulus.Comment: 18 pages, with 4 figure

Onset of Floquet Thermalisation

In presence of interactions, a closed, homogeneous (disorder-free) many-body system is believed to generically heat up to an `infinite temperature' ensemble when subjected to a periodic drive: in the spirit of the ergodicity hypothesis underpinning statistical mechanics, this happens as no energy or other conservation law prevents this. Here we present an interacting Ising chain driven by a field of time-dependent strength, where such heating onsets only below a threshold value of the drive amplitude, above which the system exhibits non-ergodic behaviour. The onset appears at {\it strong, but not fast} driving. This in particular puts it beyond the scope of high-frequency expansions. The onset location shifts, but it is robustly present, across wide variations of the model Hamiltonian such as driving frequency and protocol, as well as the initial state. The portion of nonergodic states in the Floquet spectrum, while thermodynamically subdominant, has a finite entropy. We find that the magnetisation as an {\it emergent} conserved quantity underpinning the freezing; indeed the freezing effect is readily observed, as initially magnetised states remain partially frozen {\it up to infinite time}. This result, which bears a family resemblance to the Kolmogorov-Arnold-Moser theorem for classical dynamical systems, could be a valuable ingredient for extending Floquet engineering to the interacting realm.Comment: 10 pages, including Supplemental Materia

Late onset of Huntington's disease

Twenty-five patients with late-onset Huntington's disease were studied; motor impairment appeared at age 50 years or later. The average age at onset of chorea was 57.5 years, with an average age at diagnosis of 63.1 years. Approximately 25% of persons affected by Huntington's disease exhibit late onset. A preponderance of maternal transmission was noted in late-onset Huntington's disease. The clinical features resembled those of mid-life onset Huntington's disease but progressed more slowly. Neuropathological evaluation of two cases reveal less severe neuronal atrophy than for mid-life onset disease

The Relationship between Early Disability Onset and Education and Employment

The early onset of disability (at birth through young adulthood) can affect a person's employment outcomes in myriad ways. In addition to the direct effect of disability on employment, early onset of disability likely affects the acquisition of education and job skills (human capital). This reduced "investment" in human capital in turn may reduce the individual's employment and earnings prospects throughout their lifetime. If this is the case, people with early onset of disability may be doubly disadvantaged when it comes to later employment prospects.This study analyzes how early onset of disability (onset prior to age 22) affects employment opportunities both directly and as a result of reduced investment in human capital (education) for a younger cohort (ages 22 to 35) and older cohort (ages 44 to 54). In our young cohort, we find that people with early onset of disability have a lower probability of completing high school and a lower probability of being employed than those without disabilities. Lower employment rates result from both lower levels of high school completion and a direct negative impact of disability on work. In the older cohort, we find the employment of those with disability is lower than those without disability, regardless of age of onset. However, those with early onset of disability have significantly higher employment rates than those with later onset of disability (after age 22). We hypothesize that this is a result of people with onset of disability prior to age 22 either choose careers that can be more easily accommodated than the careers people with later disability onset have, or that people with early onset of disability are more likely to be adept at seeking and using accommodations than those with later disability onset. These results suggest that policies and programs to increase employment of persons with disabilities should focus on ways to increase education levels of those with early onset of disability. They also suggest that return-to-work efforts focused on older cohorts of persons with disabilities may want to separately target programs to those with early onset of disability

Fluidity Onset in Graphene

Viscous electron fluids have emerged recently as a new paradigm of strongly-correlated electron transport in solids. Here we report on a direct observation of the transition to this long-sought-for state of matter in a high-mobility electron system in graphene. Unexpectedly, the electron flow is found to be interaction-dominated but non-hydrodynamic (quasiballistic) in a wide temperature range, showing signatures of viscous flows only at relatively high temperatures. The transition between the two regimes is characterized by a sharp maximum of negative resistance, probed in proximity to the current injector. The resistance decreases as the system goes deeper into the hydrodynamic regime. In a perfect darkness-before-daybreak manner, the interaction-dominated negative response is strongest at the transition to the quasiballistic regime. Our work provides the first demonstration of how the viscous fluid behavior emerges in an interacting electron system.Comment: 8pgs, 4fg

The role of 39 psoriasis risk variants on age of psoriasis onset.

Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored. The goal of this study was to evaluate known risk alleles of psoriasis for association with age of psoriasis onset in three well-defined case-only cohorts totaling 1,498 psoriasis patients. We selected 39 genetic variants from psoriasis GWAS and tested these variants for association with age of psoriasis onset in a meta-analysis. We found that rs10484554 and rs12191877 near HLA-C and rs17716942 near IFIH1 were associated with age of psoriasis onset with false discovery rate < 0.05. The association between rs17716942 and age of onset was not replicated in a fourth independent cohort of 489 patients (P = 0.94). The imputed HLA-C∗06:02 allele demonstrated a much stronger association with age of psoriasis onset than rs10484554 and rs12191877. We conclude that despite the discovery of numerous psoriasis risk alleles, HLA-C∗06:02 still plays the most important role in determining the age of onset of psoriasis. Larger studies are needed to evaluate the contribution of other risk alleles, including IFIH1, to age of psoriasis onset