The Slave Birth Register of Adams County

This record is from a book, deposited in the Prothonotary\u27s office, which shows the dates of birth and registration of 109 children born to slave mothers between 1799 and 1820. Several pages at the beginning of the book are missing, including the page on which are recorded the names of slaveholders whose surnames begin with A. That register might not be the original record, however. [excerpt

Prenatal X-ray exposure and childhood brain tumours: a population-based case–control study on tumour subtypes

We investigated childhood brain tumours by histological subtype in relation to prenatal X-ray among all children, less than 15 years of age, born in Sweden between 1975 and 1984. For each case, one control was randomly selected from the Medical Birth Register, and exposure data on prenatal X-ray were extracted blindly from antenatal medical records. Additional information on maternal reproductive history was obtained from the Medical Birth Register. We found no overall increased risk for childhood brain tumour after prenatal abdominal X-ray exposure (adjusted odds ratio (OR): 1.02, 95% confidence interval (CI): 0.64–1.62); primitive neuroectodermal tumours had the highest risk estimate (OR: 1.88, 95% CI: 0.92–3.83)

Breaking the myth : the association between the increasing incidence of labour induction and the rate of caesarean delivery in Finland - a nationwide Medical Birth Register study

Objectives To determine the association between the rate of labour induction and caesarean delivery. Design Medical Birth Register-based study. We used data from the nationwide Medical Birth Register collecting data on delivery outcomes on all births from 22+0 weeks and/or birth weight of at least 500 g. Setting Finland. Participants 663 024 live births in Finland from 2008 to 2019. Main outcome measures The rates of labour induction and caesarean delivery. Results The rate of labour induction increased from 17.8% to 30.3%; p Conclusions The 70% increase in the rate of labour induction in Finland has not led to a significant increase in the rate of caesarean delivery, which has remained one of the lowest in the world. Pregnant women in Finland are more frequently obese, older and diagnosed with gestational diabetes, which may partly explain the increase in the rate of labour induction.Peer reviewe

Supporting information for National, regional, and worldwide estimates of low birthweight rates in 2015, with trends from 2000: a systematic analysis

Data produced by the World Health Organization, UNICEF, LSHTM and Johns Hopkins University to estimate national low birthweight (LBW) and numbers for 195 countries. LBW data was collated through a systematic review of national routine/registration systems, nationally representative surveys, and other data sources, and subsequently modelled using restricted maximum likelihood estimation with country-level random effects. Data includes a list of 1447 rate data points used as an input to the modelled estimates, yearly national-level covariates for each of the 195 countries studied from 2000 to 2015, and information on estimated low birthweight rates from 2000 to 2015 for 148 countries with data. Stata code used to generate these estimates is provided

Smoking during pregnancy reduces vitamin D levels in a Finnish birth register cohort

Objective Maternal vitamin D level in pregnancy may have implications for both the mother and fetus. Deficiency of vitamin D has been linked to several pregnancy complications and fetal skeletal health. Smoking has been associated with reduced serum level of the vitamin D metabolite, 25-hydroxyvitamin D (25(OH)D). Design A nested case-control study within the Finnish Maternity Cohort, a population-based cohort which includes first-trimester sera from 98 % of pregnancies in Finland since 1987. The selection consisted of women with uncomplicated pregnancies. We studied serum concentration of 25(OH)D in 313 non-smoking and forty-six self-reported smoking pregnant women. Setting We hypothesize that pregnant smokers may have an increased risk of low 25(OH)D levels especially during winter months. Participants A control group from an unpublished pregnancy complication study consisting of 359 uncomplicated pregnancies. Individuals who reported that they do not smoke were considered 'non-smokers' (n 313) and those who reported continued smoking after the first trimester of pregnancy were considered 'smokers' (n 46). Results Smokers had significantly lower levels of 25(OH)D irrespective of sampling time (PPeer reviewe

Umbilical artery pH and base excess at birth are poor predictors of neurodevelopmental morbidity in early childhood

Abstract Aim We sought to evaluate the associations between umbilical artery pH and base excess and neurodevelopmental outcome at four years of age. Methods This study comprised 84,588 singleton children born alive at term in 2005-2011 in the hospital district of Helsinki and Uusimaa in Finland. Data from the maternity hospital information system were linked to the data from the Medical Birth Register and the Hospital Discharge Register. Neurodevelopmental morbidity included cerebral palsy, epilepsy, intellectual or sensorineural impairment. Results After adjustment for maternal and perinatal factors, a combination of pHPeer reviewe

Birth weight and family status revisited: evidence from Austrian register data

In this paper, we study the socio-economic determinants of birth weight with a focus on the mother’s family status. We use Austrian birth register data covering all births between 1984 and 2007 and find that a mother’s marriage is associated with a higher birth weight of the newborn in a range between 4 and 6 dekagrams. This result remains stable if we control for time-invariant unobserved mother heterogeneity. A divorce around pregnancy results in birth weight 2 to 8 dekagrams lower as compared to that of newborn babies of single mothers. The family status effects in the 2000s are stronger as they were in the 1980s. A quantile regression suggests that family effects are more pronounced at the lower quantiles of the birth weight distribution and diminish at higher percentiles. Finally, in accordance with several instrumental variable (IV) studies, we find that the significantly positive impact of family status on children’s health outcomes disappears if we confine our sample to mothers, who are below the age of 22 years. We conclude that social and financial stress may have an important influence on the birth weight of newborns, especially at the lower tail of the birth weight distribution.Low birth weight, family status, newborn health, fixed-effects estimations

Risks of hospitalization and drug consumption in children and young adults with diagnosed celiac disease and the role of maternal education: A population-based matched birth cohort study

Background: Celiac disease (CD) may affect healthcare use in children and young adults. Socio-economic factors may act as a confounder or effect modifier. We assessed such hypotheses in a population-based birth cohort of young celiac subjects and references matched by maternal education. Methods: The cohort included all newborns recorded in the Medical Birth Register of Friuli-Venezia Giulia Region (Italy) between 1989 and 2011. CD incident cases were identified through pathology reports, hospital discharges and copayment exemptions and matched with up to five references by sex, year of birth and maternal education. Cox regression models were used to estimate Hazard Ratios (HRs) for major causes of inpatient diagnosis and drug prescription occurring after diagnosis in CD patients compared to references, stratifying by time of first event and maternal education. Results: We identified 1294 CD cases and 5681 references. CD cases had a higher risk of hospital admission for any cause (HR: 2.34; 95 % CI 2.08-2.63) and for all major ICD9-CM categories except obstetric complications, skin and musculoskeletal diseases, and injuries and poisoning. Prescription of all major ATC drug categories, except dermatologicals and genito-urinary medications, was significantly increased in CD subjects. For most outcomes, HRs were highest in the first year after CD diagnosis but remained significant after five or more years. HRs were similar across different categories of maternal education. Conclusions: Diagnosed CD subjects had a higher risk of hospitalization and medication use compared to the general population, even five or more years after diagnosis, with no effect modification of maternal education