Prophylactic therapy with Fibrogammin ® P is associated with a decreased incidence of bleeding episodes: a retrospective study

Congenital factor XIII (FXIII) deficiency is an extremely rare, yet potentially life-threatening, bleeding disorder, with a 30% rate of spontaneous intracranial haemorrhage. Routine prophylactic management is recommended for all individuals with clinically relevant (FXIII) deficiency and for all symptomatic individuals with congenital factor deficiency. Fibrogammin ® P is a purified, pasteurized concentrate of FXIII that appears to carry negligible risk of viral transmission, unlike other unprocessed products containing FXIII. An ongoing Phase II/III study of Fibrogammin ® P in patients with congenital FXIII deficiency is being conducted to evaluate the prophylactic efficacy and long-term safety of this product. Using retrospective chart review data from subjects enrolled in the Phase II/III study, the current analysis was designed to compare spontaneous bleed-event rates prior to and after the initiation of Fibrogammin ® P prophylaxis. Seven subjects were evaluable for comparison, having received no other prophylactic FXIII-containing product during the 24 months prior to study entry. The mean annual number of spontaneous bleeds was 2.5 events per year prior to Fibrogammin ® P prophylaxis and 0.2 events per year during Fibrogammin ® P prophylaxis ( P  = 0.01). Patients reported no severe bleeds during Fibrogammin ® P therapy. This small sample supports a consistent and clinically meaningful reduction in spontaneous bleeding with prophylactic use of Fibrogammin ® P.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79140/1/j.1365-2516.2009.02123.x.pd

The Struggle for Control: How do Norwegian TV-Celebrities Deal With Critical Media Exposure?

Ten Norwegian TV-hosts, all nation-wide celebrities, were interviewed about their experiences with critical media exposure. How did they perceive their relationship with the press?  What were the main sources of stress? How did they cope? All expressed a strong focus on impression management and self-presentation. The majority described an independent and often playful interaction with the press, in order to keep control over their programs and their privacy.All had experienced negative media exposure. Sources of stress were one-sided presentations, evil informers, personal attacks, and harming their family. They experienced both direct effects by the media coverage, and indirect effects through interaction with other people.The majority used problem-focused coping strategies, actively influencing the media coverage; emotion-focused strategies, regulating their thoughts and feelings; and meaning-focused strategies, allowing reflection. Proactive self-presentation work helped maintain and protect their identities.Two of the participants reported using more defensive strategies, and had suffered more intensely

Continuum simulations of shocks and patterns in vertically oscillated granular layers

We study interactions between shocks and standing-wave patterns in vertically oscillated layers of granular media using three-dimensional, time-dependent numerical solutions of continuum equations to Navier-Stokes order. We simulate a layer of grains atop a plate that oscillates sinusoidally in the direction of gravity. Standing waves form stripe patterns when the accelerational amplitude of the plate's oscillation exceeds a critical value. Shocks also form with each collision between the layer and the plate; we show that pressure gradients formed by these shocks cause the flow to reverse direction within the layer. This reversal leads to an oscillatory state of the pattern that is subharmonic with respect to the plate's oscillation. Finally, we study the relationship between shocks and patterns in layers oscillated at various frequencies and show that the pattern wavelength increases monotonically as the shock strength increases.Comment: 12 pages, 9 figure

Thermomechanical and bithermal fatigue behavior of cast B1900 + Hf and wrought Haynes 188

High temperature thermomechanical and bithermal fatigue behavior was investigated for two superalloys: cast nickel-base B1900+Hf and wrought cobalt-base Haynes 188. Experimental results were generated to support development of an advanced thermal fatigue life prediction method. Strain controlled thermomechanical and load-controlled, strain-limited, bithermal fatigue tests were used to determine the fatigue crack initiation and cyclic stress-strain response characteristics of superalloys. Bithermal temperatures of 483 and 871 C were used for B1900+Hf, and 316 and 760 C for Haynes 188. Thermomechanical fatigue tests were conducted by using maximum and minimum temperatures corresponding to those for the bithermal experiments. Lives cover the range from about 10 to 3000 cycles to failure. Isothermal fatigue results obtained previously are also discussed

Anticardiolipin antibodies and coronary heart disease

Arterial or venous thrombotic events have been described as complications in patients with positive anticardiolipin antibodies (aCL), affecting various organs including the heart. In order to see whether aCL could be, among others, a predisposing factor for coronary artery occlusions and whether it could serve as a prognostic marker for coronary heart disease, 232patients enrolled in the European Concerted Action on Thrombosis Angina Pectoris Study were studied. aCL and various other haemostatic parameters were determined at time of admittance in order to see whether a relationship existed between haemostasis at baseline and extent or prognosis of the cardiovascular disease. A follow-up at 12 and 24 months after angiography included information about relapsing coronary or other thrombotic events, treatment and outcome of the disease. aCL were not found to be a marker of either progressive cardiovascular disease or recurrent thrombotic events. No correlation was found, either in aCL positive or in aCL negative patients, between high levels of haemostasis activation markers, such as fi-thromboglobulin, platelet factor 4 or fibrinopeptide A and recurrent cardiovascular diseas

Quantifizierung und motorisch-funktionelle Analyse von postlesional beobachtbaren Tyrosinhydroxylase-immunreaktiven Neuronen im 6-OHDA-Parkinson-Modell der Maus

Diese Arbeit hat es sich zur Aufgabe gemacht, nach 6-OHDA-Läsion im Striatum von Mäusen nachweisbare TH-positive Zellen in einem zeitlichen Umfang von drei Monaten nach der Läsion zu quantifizieren und anhand motorischer Tests mit dem Verhalten zu korrelieren. Genutzt wurden immunhistochemisches BrdU/TH-double-labbeling sowie der Zylindertest und der apomorphininduzierte Rotationstest. Es stellte sich keine Doppelmarkierung im Sinne einer adulten Neurogenese dar. Die Zahl der TH-positiven Zellen zeigte sich konstant und führte zu keiner Änderung der motorischen Leistung der Versuchstiere