90 research outputs found

    INTELLIGENCE PROFILE OF CHILDREN WITH A HISTORY OF INSTITUTIONAL CARE: A LONGITUDINAL STUDY

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    Intelligence is the general mental capacity that involves using the ability to reason, plan, solve problems, think abstractly and learn from experience, in addition to allowing the acquisition of new learning over time that require logical and abstract relationships, as well as the ability to solve increasingly complex problems. Despite the prominent role played by genetic inheritance, when analyzing the different trajectories of human development, empirical evidence reveals the influence of the context on the development of intelligence and the structuring of distinct intellectual profiles over time. One of these development contexts may be the Institutional Home, a protective measure aimed at guaranteeing the rights and protection of children and adolescents. Thus, this study aimed to describe the intelligence profile of children with a history of institutionalization in the Metropolitan Region of Belém. This is a longitudinal study, of a quantitative and qualitative nature, in which 15 children, located in two municipalities in the metropolitan region of Belém, who were in the childcare services participated. Data collection took place between December 2017 and December 2018, in three stages, with an interval of six months between each stage, forming two different groups: Group 1, formed by four children institutionalized throughout the research and Group 2, consisting of eleven children who were with their family at the last moment of the collection. The results show statistically significant differences regarding the average IQ in the three assessment moments, emphasizing that children in G1 have a low intellectual profile when compared to the participants in G2. Cognitive development was associated with the interaction of the individual attributes of each participant with the characteristics of their developmental context. In this sense, the existence of an unfavorable particularity, such as having psychopathological complications and being in an institutional environment, generated a low intellectual profile. On the other hand, having experienced situations of vulnerability and institutionalization, without the emergence of severe mental disorders and being reinserted in the family, made it possible to overcome intellectual damage generated by adverse experiences, provided that in the family context there were adults available for establishing a bond, carrying out joint activities and providing personalized care

    Urban sewage sludge stabilization by alkalization-composting-vermicomposting process: Crop-livestock residue use.

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    Waste management practices are vital for human health and the environment in a world where natural resources stress is expected to increase with the growth of population. Our study aimed to evaluate the potential use of crop-livestock residue as a bulking agent associated with the ideal level of hydrated lime for the stabilization and sanitization of urban sewage sludge through the alkalization-composting process. Therefore, we determined the alkalization efficiency on the heavy metal concentration in urban sewage sludge, quantified the viable eggs of helminths in pure and alkalized sludge, and measured the rate of earthworms (Eisenia fetida) surviving in the vermicomposting process using different levels of alkalized urban sewage sludge associated with crop-livestock residue. Four sequential trials were carried out in a completely randomized design with three replicates. The lime alkalization reduced the levels of Ba, As, Pb, Cu, Cr, Mo, Ni, and Zn compared to the pure urban sewage sludge. Using 30% w/w of lime in the urban sewage sludge (SS-30) for composting process reduced the viable helminth eggs by 71, 72, and 69% for sugarcane bagasse (Saccharum officinarum; SB), fresh chopped Napier-grass (Pennisetum purpureum; NG), and bovine ruminal content (BR), respectively. The ideal level of hydrated lime for stabilization and sanitization of urban sewage sludge was found to be 30%, which was able to reduce the heavy metals. The residues have the potential as a bulking agent for the composting of urban sewage sludge when associated with alkalization. The lime alkalization decreases the total number of helminth eggs and the number of viable eggs. The possibility of starting a vermicomposting using the mixtures is promising, evidenced by the earthworm survival in composting urban sewage sludge mixed with crop-livestock residues after 45 days of composting. The earthworm survival is maintained by an association of at least 80% of the crop-livestock residues

    GEOCHEMISTRY AND U-Pb GEOCHRONOLOGY OF THE NEOARCHEAN GNEISSES AND PALEOPROTEROZOIC GRANITES FROM JANU√ĀRIA HIGH: RECORDS OF JUVENILE AND YOUTHFUL EARTH IN THE S√ÉO FRANCISCO CRATON NUCLEUS (BRAZIL): Geoqu√≠mica e geocronologia U-Pb dos gnaisses neoarqueanos e granitos paleoproterozoicos do Alto de Janu√°ria: registros da Terra Juvenil e Jovem no n√ļcleo do Cr√°ton S√£o Francisco (Brasil)

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    Within the proposal of secular evolution of the Earth system divided into seven phases: ‚ÄúProto-Earth‚ÄĚ (4.57‚Äď4.45 Ga); ‚ÄúPrimordial Earth‚ÄĚ (4.45‚Äď3.80 Ga); ‚ÄúPrimitive Earth‚ÄĚ (3.8‚Äď3.2 Ga); ‚ÄúJuvenile Earth‚ÄĚ (3.2‚Äď2.5 Ga); ‚ÄúYouthful Earth‚ÄĚ (2.5‚Äď1.8 Ga); ‚ÄúMiddle Earth‚ÄĚ (1.8‚Äď0.8 Ga); and ‚ÄúContemporary Earth‚ÄĚ (since 0.8 Ga), the 2.61-2.64 Ga High-K, meta- to peraluminous Janu√°ria High orthogneisses are inserted in the context of almost rigid behavior of the lithosphere, by the end of the Juvenile Earth. With protolith origin suggestive of intracrustal partial melting of local older TTG (tonalite-trondhjemite-granodiorite), these orthogneisses are the representatives in the S√£o Francisco craton nucleus of the 2.8 Ga to 2.6 Ga potassic rocks found in archean cratons worldwide, and the occurrence of these rocks is a defining characteristic of the Juvenile Earth. Supported on evidence of the plate tectonic activity in Paleoproterozoic, the 2.14-2.19 Ga Janu√°ria High biotite granites are inserted in the context of Youthful Earth and they are the record of accretionary orogeny delineated by the edification of magmatic arc at that time. They are calc-alkaline, I-type rocks typical of subduction-related continental magmatic arcs. These biotite granites are probably derived from a High-K mafic source associated with tonalites.ABSTRACT - Within the proposal of secular evolution of the Earth system divided into seven phases: ‚ÄúProto-Earth‚ÄĚ (4.57‚Äď4.45 Ga); ‚ÄúPrimordial Earth‚ÄĚ (4.45‚Äď3.80 Ga); ‚ÄúPrimitive Earth‚ÄĚ (3.8‚Äď3.2 Ga); ‚ÄúJuvenile Earth‚ÄĚ (3.2‚Äď2.5 Ga); ‚ÄúYouthful Earth‚ÄĚ (2.5‚Äď1.8 Ga); ‚ÄúMiddle Earth‚ÄĚ (1.8‚Äď0.8 Ga); and ‚ÄúContemporary Earth‚ÄĚ (since 0.8 Ga), the 2.61-2.64 Ga High-K, meta- to peraluminous Janu√°ria High orthogneisses are inserted in the context of almost rigid behavior of the lithosphere, by the end of the Juvenile Earth. With protolith origin suggestive of intracrustal partial melting of local older TTG (tonalite-trondhjemite-granodiorite), these orthogneisses are the representatives in the S√£o Francisco craton nucleus of the 2.8 Ga to 2.6 Ga potassic rocks found in Archean cratons worldwide, and the occurrence of these rocks is a defining characteristic of the Juvenile Earth. Supported on evidence of the plate tectonic activity in Paleoproterozoic, the 2.14-2.19 Ga Janu√°ria High biotite granites are inserted in the context of Youthful Earth and they are the record of accretionary orogeny delineated by the edification of magmatic arc at that time. They are calc-alkaline, I-type rocks typical of subduction-related continental magmatic arcs. These biotite granites are probably derived from a high-K mafic source associated with tonalites. RESUMO - Dentro da proposta da evolu√ß√£o secular do sistema Terra dividido em sete fases: ‚ÄúProto-Terra‚ÄĚ (4,57‚Äď4,45 Ga); ‚ÄúTerra Primordial‚ÄĚ (4,45‚Äď3,80 Ga); ‚ÄúTerra Primitiva‚ÄĚ (3,8‚Äď3,2 Ga); ‚ÄúTerra Juvenil‚ÄĚ (3,2‚Äď2,5 Ga); ‚ÄúTerra Jovem‚ÄĚ (2,5‚Äď1,8 Ga); ‚ÄúTerra M√©dia‚ÄĚ (1,8‚Äď0,8 Ga); e ‚ÄúTerra Contempor√Ęnea‚ÄĚ (desde 0,8 Ga), os ortognaisses meta- a peraluminosos de alto-K de 2,61-2,64 Ga do Alto Janu√°ria est√£o inseridos no contexto de comportamento quase r√≠gido da litosfera, no final da ‚ÄúTerra Juvenil‚ÄĚ. Com origem de seu prot√≥lito sugestiva de fus√£o parcial intracrustal dos TTG (tonalito-trondhjemito-granodiorito) locais mais antigos, esses ortognaisses s√£o os representantes no interior do cr√°ton do S√£o Francisco das rochas pot√°ssicas de 2,8 Ga a 2,6 Ga encontradas em cr√°tons arqueanos em todo o mundo, e a ocorr√™ncia dessas rochas √© uma caracter√≠stica definidora da ‚ÄúTerra Juvenil‚ÄĚ. Apoiados nas evid√™ncias da atividade da tect√īnica de placas no Paleoproteroz√≥ico, os biotita granitos de 2,14-2,19 Ga do Alto de Janu√°ria est√£o inseridos no contexto da ‚ÄúTerra Jovem‚ÄĚ, s√£o o registro da orogenia acrescion√°ria delineada pela edifica√ß√£o de arco magm√°tico continental nessa √©poca e tratam-se de rochas c√°lcio-alcalinas do tipo I, t√≠picas de arcos, provavelmente derivadas de uma fonte m√°fica de alto K associada a tonalitos

    Research trends and perspectives on hydrothermal gasification in producing biofuels

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    Several researchers around the world have been investigating the use of supercritical fluids incorporated into the process to create a method known as hydrothermal gasification (HTG). Thus, the present study aims to evaluate what has been produced regarding biofuels produced from HTG. A bibliometric analysis of the Web of Science (WoS) database was performed for articles published between 2006 and 2022. In the first analysis, 331 articles were identified, and refined analyses for 320 and 311 publications of the Web of Science Core Collection database (2006- 2022) were performed using VOSviewer, CiteSpace, and Microsoft Excel. The year 2022 had the highest number of articles, with 54 publications, followed by 2021 and 2015 with 45 and 31 publications, respectively. The three journals with the most significant impact were Bioresource Technology, Algal Research: Biomass Biofuels And Bioproducts, and Biomass & Bioenergy, with TPs of 26, 18, and 17, respectively. China, the USA, and Canada represented 11.48%, 10.89%, and 7.52% of the total publications. Investments in research on supercritical fluids and carbonization should be more significant in countries that publish more. Much research still needs to be done for the advancement of the area, as evidenced by the low number of publications. Future studies should focus on related technologies such as liquefaction and pyrolysi

    Productive and economic performance of feedlot young Nellore bulls fed whole oilseeds

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    ABSTRACT The effects of diets containing oilseeds were measured to evaluate the productive and economic parameters in the finishing of young, feedlot Nellore bulls. Twenty-four young Nellore bulls were used, with an initial body weight (BW) of 311.46¬Ī0.37 kg and 24 months of age, distributed into individual stalls ( 4 √ó 20 m) in a completely randomized design, totaling four treatments with six repetitions per treatment. Four diets (control, based on corn and soybean meal, and three diets containing cottonseed, soybean, and sunflower) were evaluated. Feed and orts were measured daily to calculate intake and costs. The dry matter intake of the control group was higher than soybean (10.64 kg/day), cotton (9.88 kg/day), and sunflower (9.30 kg/day) treatments, respectively. The cottonseed treatment showed the highest average neutral detergent fiber intake. There was a dietary effect of diets on average daily gain, total weight gain, and final weight. The soybean treatment showed the highest performance, total gain (232.55 kg), and final weight (544.38 kg). Oilseed intake can modify the fatty acids profile in the meat, decreasing its saturated fatty acid content. Whole soybean seed favors performance, improves feed efficiency, fatty acid profile, and fat distribution in the carcass, and can reduce production costs

    Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

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    Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)

    Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis

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    The unique properties of metal-organic frameworks (MOFs) such as their large surface area and high porosity have attracted considerable attention in recent decades. The MOFs are a promising class of materials for developing highly efficient biosensors due to these same properties. This bibliometric analysis focused on the use of MOFs as enzyme-coupled materials in biosensor construction and aimed to provide a comprehensive overview of the research field by analyzing a collected database. The analysis included identifying the countries that have published the most, the most prominent applications, and trends for future directions in the field. The study used three databases with different numbers of documents, differentiated by research areas, with refinements made to the search as needed. The results suggest that MOF-derived biosensors are a growing field, with the Republic of China emerging as a significant contributor to research in this area. The study also used computational processing of trend analysis and geocoding to reveal these findings

    XIV Jornada de Investigación 2023

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    Eje tem√°tico I: derecho, cultura y sociedad: En este eje tam√°tico, se presentan ponencias que tienen como prop√≥sito analizar y explicar cr√≠ticamente, a trav√©s de la investigaci√≥n cient√≠fica y desde el enfoque interdisciplinar, los derechos humanos, el proceso de estructuraci√≥n de La convivencia y la equidad en la vivencia de los derechos; los valores, las costumbres, las normas, los estilos de vida, el uso de artefactos y la organizaci√≥n social; los procesos de desarrollo espiritual, de conocimiento cient√≠fico, de desarrollo tecnol√≥gico y est√©tico, y la convivencia y sus implicaciones en lo p√ļblico y lo privado. Eje tem√°tico II: desarrollo humano y sostenible. El segundo eje tem√°tico que abord√≥ la XII Jornada de Investigaci√≥n fue desarrollo humano y sostenible, con ponencias que abarcaron todos aquellos aspectos que van, desde el desarrollo y bienestar individual, pasando por los estudios de las comunidades, para llegar a una comprensi√≥n global de la sostenibilidad como un factor determinante de existencia de las sociedades. Eje tem√°tico III: gesti√≥n y tecnolog√≠a al servicio de la sociedad. Finalmente, en la XII Jornada de Investigaci√≥n, se trabaj√≥el eje tem√°tico gesti√≥n y tecnolog√≠a al servicio de la sociedad, en el cual se presentaron, desde las diferentes disciplinas, ponencias que aportaron al campo del desarrollo productivo y a la soluci√≥n de los problemas de la sociedad a trav√©s de las oportunidades que una buena gesti√≥n y un apropiado uso de la tecnolog√≠a ofrece. (Tomado de la Fuente)EJE TEM√ĀTICO I: DERECHO, CULTURA Y SOCIEDAD La respuesta econ√≥mica a la pandemia dentro del Estado social de derecho colombiano. Los espacios intermediarios como contenedores de experiencias significativas. An√°lisis del estilo ling√ľ√≠stico aplicado a la psicolog√≠a jur√≠dica. ¬ŅDejar o transformar? Cinco puntos para entender la ciudad contempor√°nea. Studiositas y verdad en la educaci√≥n centrada en la persona. Los derechos de autor en el contrato de trabajo y de prestaci√≥n de servicios. Afectaci√≥n de los derechos sexuales reproductivos femeninos durante el conflicto armado en Colombia. Problemas del acceso a la justicia del campesinado de los p√°ramos de Sumapaz y Santurb√°n. Vulneraci√≥n del derecho al agua potable en La Guajira: una falta de garant√≠as. Derechos humanos e inteligencia militar: el dilema de la primac√≠a del inter√©s general sobre el particular. Cuantificaci√≥n del dolor humano por parte de la justicia colombiana. Retos tecnol√≥gicos en el derecho vs. Limitaciones en Colombia en las poblaciones m√°s vulnerables. Construir identidad territorial a trav√©s del corredor socioambiental Los Nevados. La naturaleza en la arquitectura: una mirada a la arquitectura del siglo XX. Contrato de trabajo del futbolista profesional. La baja educaci√≥n en las zonas rurales por consecuencia del conflicto armado y la corrupci√≥n en el Estado colombiano. Incidentes de la migraci√≥n venezolana en el √°mbito normativo nacional colombiano e internacional. Legalizaci√≥n definitiva del consumo adulto del cannabis en Colombia: un debate jur√≠dico y constitucional. Wawamia jai, s√≠ndrome propio de la cultura: una caracterizaci√≥n de los signos y s√≠ntomas de una enfermedad cultural del pueblo ind√≠gena ember√°-kat√≠o. La cruda realidad del reclutamiento de ni√Īos, ni√Īas y adolescentes en el conflicto armado en Colombia: una visi√≥n nacional e internacional. EJE TEM√ĀTICO II: DESARROLLO HUMANO Y SOSTENIBLE Migraci√≥n venezolana en Colombia: perspectiva cr√≠tica sobre el derecho de acceso a la salud. El estr√©s laboral. Una imagen no es tradici√≥n: la actualidad de la vivienda raizal en el Archipi√©lago de San Andr√©s, Providencia y Santa Catalina. Aprendizajes del proceso de dise√Īo basado en la investigaci√≥n: caso de estudio barrio Concepci√≥n Norte, Bogot√°, Colombia. Sumapaz como territorio potencial h√≠drico y patrimonio paisaj√≠stico y cultural: modelo de regi√≥n sostenible. Revisi√≥n sistem√°tica del liderazgo digital desde las competencias digitales. Intervenciones psicol√≥gicas basadas en evidencia: tendencias actuales. Herramientas pedag√≥gicas para la concientizaci√≥n de la comunidad a partir del reconocimiento de la memoria hist√≥rica en el barrio San Benito, Bogot√°, Colombia. Dise√Īo sostenible como factor diferencial en la reconversi√≥n industrial de las curtiembres en el barrio San Benito, Bogot√°, Colombia. Motivaci√≥n escolar como factor relacionado con el rendimiento acad√©mico en estudiantes en extraedad en la Instituci√≥n Educativa Distrital Rep√ļblica de M√©xico, sede B, jornada ma√Īana. La realidad de los objetos artificiales. Performance en nuestro diario vivir. ¬ŅEs necesario la modificaci√≥n del lugar para satisfacer las necesidades del ser humano? ¬ŅEs necesario hacer modificaciones al espacio natural para generar cultura? La arquitectura como s√≠ntesis entre los objetos con prop√≥sito o sin √©l. La creaci√≥n de los objetos y sus impactos en el mundo. ¬ŅCu√°les son los determinantes de las brechas de competencia laboral en el departamento de Cundinamarca, Colombia? Buenas pr√°cticas de habitabilidad. Reconocimiento de la arquitectura dom√©stica tradicional en Colombia como una pauta de identidad para el dise√Īo de nuevas viviendas. Validaci√≥n de un instrumento para evaluar la procrastinaci√≥n acad√©mica. Escala de medici√≥n de la soledad BATAN. Contraste entre el instrumento para medir la resiliencia en adultos j√≥venes de Colombia (CLANP) con CD-RISC 10. Finlandia y naturaleza: pa√≠s modelo en ratificaci√≥n de normas y tratados para la protecci√≥n de los derechos de la naturaleza. EJE TEM√ĀTICO III: GESTI√ďN Y TECNOLOG√ćA AL SERVICIO DE LA SOCIEDAD Aplicaci√≥n de una tecnolog√≠a limpia desde el dise√Īo resiliente: simulaci√≥n de un m√≥dulo b√°sico de vivienda social en la ciudad de Tunja, Colombia. Recorrido virtual de la Universidad Cat√≥lica de Colombia Sede Claustro para la inducci√≥n de estudiantes y docentes. Evaluaci√≥n de eficiencia de un prototipo de un sistema de atrapanieblas tipo NRP 3.0 para la vereda Gaunza Arriba, municipio de Guateque, departamento de Boyac√°, Colombia. Sistema de Informaci√≥n para la Coordinaci√≥n de Trabajos de Grado del Programa de Ingenier√≠a de Sistemas de la Universidad Cat√≥lica de Colombia (SIGETG). Estrategias de sostenibilidad para la reducci√≥n de la huella h√≠drica en la vivienda de la Costa Caribe. Sistema de evaluaci√≥n de resultados de aprendizaje de la Facultad de Psicolog√≠a de la Universidad Cat√≥lica de Colombia. Identificaci√≥n de tendencias en la implementaci√≥n de DevOps a partir de una revisi√≥n sistem√°tica. Desarrollo de un algoritmo de trading para operar el mercado de divisas a trav√©s de ondas de Elliott y n√ļmeros de Fibonacci. Los derechos humanos en el espacio de la inteligencia artificial. Construcci√≥n de paz a trav√©s del ciberactivismo en redes sociales de cuatro organizaciones juveniles de Bogot√°. Las redes sociales digitales como herramienta educativa: una propuesta de investigaci√≥n-innovaci√≥n. Videojuego de realidad virtual sobre la extracci√≥n y el tr√°fico ilegal de la fauna silvestre en Colombia. Arquitectura de la informaci√≥n de la plataforma de inteligencia artificial para el estudio neurocognitivo y el apoyo a la salud mental. Inmersi√≥n sobre la innovaci√≥n: perspectivas sobre el derecho al trabajo y la inteligencia artificial en el servicio de justicia. El ciberterrorismo en la legislaci√≥n colombiana: un an√°lisis desde la criminolog√≠a. Modelo de fabricaci√≥n digital de dise√Īo sostenible para vivienda social. Uso de los videojuegos en el campo educativo: ventajas y desventajas. Resoluci√≥n electr√≥nica de controversias en procesos civiles de m√≠nima cuant√≠a en Colombia. Estrategia de evaluaci√≥n y promoci√≥n de la salud mental en el contexto universitario. Caracterizaci√≥n de t√©cnicas y herramientas de inteligencia artificial utilizadas para el perfilamiento de clientes por las mipymes en Colombia. Transformar el casco urbano del municipio de L√≠bano, departamento del Tolima, Colombia: un proyecto parque industrial para el intercambio de saberes y revitalizaci√≥n ambiental. Aplicaci√≥n tecnol√≥gica en agricultura urbana para promover la seguridad alimentaria en poblaciones vulnerables. CONCLUSIONE

    O IMPACTO DAS MUTA√á√ēES EM UM GENE RECEPTOR DO TIPO TOLL E SUA ASSOCIA√á√ÉO COM A TEMPESTADE DE CITOCINAS EM PACIENTES COM COVID-19 EM UMA POPULA√á√ÉO NA AMAZ√ĒNIA

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    Introdu√ß√£o/Objetivo: parte da resposta inata s√£o os receptores do tipo Toll (TLR) que agem na express√£o de genes, ativando citocinas e fag√≥citos. A resposta amplificada pode gerar a tempestade de citocinas, prejudicando a cl√≠nica dos pacientes, como observado na COVID-19. Assim, o objetivo do estudo foi avaliar a influ√™ncia da presen√ßa de muta√ß√Ķes nos TLRs e sua contribui√ß√£o na tempestade de citocinas em pacientes com COVID-19. M√©todos: analisamos o exoma de 68 indiv√≠duos infectados pelo SARS-CoV-2 confirmado por RT-PCR, internados em estado grave em Bel√©m-PA. O DNA foi extra√≠do de amostras de swab nasal. A prepara√ß√£o da biblioteca foi realizada com o Exome Panel (Illumina). Para captura do exoma foi utilizado o DNA Prep with Exome v2, sequenciado com Illumina NextSeq 550 Systems. A chamada de variantes foi realizada de acordo com GATK Best Practice Guidelines, com ferramentas BWA para mapeamento e Picard para pr√©-processamento. A biblioteca foi preparada com Exome Panel (Illumina). A anota√ß√£o dos dados foi realizada pelos bancos CLINVAR, COSMIC, DBNSFP, BRCA e EXAC. Resultados: duas muta√ß√Ķes foram observadas no gene TLR8 (rs5744080 e rs2407992) do cromossomo X. Para rs5744080, dos 68 pacientes no estudo, 41 foram homozigotos (18) ou heterozigotos (23) e apresentaram p-valor‚ÄĮ=‚ÄĮ0.074995 e odds ratio‚ÄĮ=‚ÄĮ-0.7757423. Para rs2407992, das 68 pessoas, 42 foram homozigotas (23) ou heterozigotas (19) com p-valor‚ÄĮ=‚ÄĮ0.0141582 e odds ratio‚ÄĮ=‚ÄĮ-1.059.293. Um √ļnico paciente n√£o apresentou ambas as muta√ß√Ķes. Al√©m da associa√ß√£o com a gravidade cl√≠nica, buscamos associar essas variantes a marcadores inflamat√≥rios indicadores da tempestade de citocinas. Entretanto, n√£o foi poss√≠vel observar uma associa√ß√£o significativa entre a prote√≠na C reativa (3-50 mg; p-valor‚ÄĮ=‚ÄĮ0.80; OR‚ÄĮ=‚ÄĮ0.78; IC95%‚ÄĮ=‚ÄĮ0.26-2.31), ferritina (>500 mg/L; p-valor‚ÄĮ=‚ÄĮ0.46; OR‚ÄĮ=‚ÄĮ1.46; IC95%‚ÄĮ=‚ÄĮ0.48-4.40), linf√≥citos (5-50.103/¬ĶL; p-valor‚ÄĮ=‚ÄĮ1; OR‚ÄĮ=‚ÄĮ1.27; IC95%‚ÄĮ=‚ÄĮ0.24-8.64), neutr√≥filos (>50.103/¬ĶL; p-valor‚ÄĮ=‚ÄĮ0.39; OR‚ÄĮ=‚ÄĮ1.86; IC95%‚ÄĮ=‚ÄĮ0.52-7.74), leuc√≥citos totais (>25.103/¬ĶL; p-valor‚ÄĮ=‚ÄĮ0.21; OR‚ÄĮ=‚ÄĮ2.05; IC95%‚ÄĮ=‚ÄĮ0,68-6.52). Conclus√£o: no gene TLR8 associado aos v√≠rus, como o SARS-CoV-2, rs2407992 foi significante, mostrando que a presen√ßa pode alterar a evolu√ß√£o da COVID-19 com maior ativa√ß√£o da resposta imune por poss√≠vel tempestade de citocinas, dado os n√≠veis aumentados dessas c√©lulas e marcadores inflamat√≥rios nos pacientes. O restante n√£o obteve signific√Ęncia estat√≠stica por baixo n√ļmero amostral

    Factors influencing terrestriality in primates of the Americas and Madagascar

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    Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkeys (catarrhines), it is largely absent among monkeys of the Americas (platyrrhines), as well as galagos, lemurs, and lorises (strepsirrhines), which are mostly arboreal. Numerous ecological drivers and species-specific factors are suggested to set the conditions for an evolutionary shift from arboreality to terrestriality, and current environmental conditions may provide analogous scenarios to those transitional periods. Therefore, we investigated predominantly arboreal, diurnal primate genera from the Americas and Madagascar that lack fully terrestrial taxa, to determine whether ecological drivers (habitat canopy cover, predation risk, maximum temperature, precipitation, primate species richness, human population density, and distance to roads) or species-specific traits (bodymass, group size, and degree of frugivory) associate with increased terrestriality. We collated 150,961 observation hours across 2,227 months from 47 species at 20 sites in Madagascar and 48 sites in the Americas. Multiple factors were associated with ground use in these otherwise arboreal species, including increased temperature, a decrease in canopy cover, a dietary shift away from frugivory, and larger group size. These factors mostly explain intraspecific differences in terrestriality. As humanity modifies habitats and causes climate change, our results suggest that species already inhabiting hot, sparsely canopied sites, and exhibiting more generalized diets, are more likely to shift toward greater ground use
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