707 research outputs found

    An innovative mobile application for construction programme managers

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    Construction programme management is a complex and information-intensive environment. The construction programme management team requires access to construction information in real-time and when needed. The current increasing use of mobile devices offers an opportunity to meet this need. The efficient management of construction programmes is one of the major factors for improving stakeholders’ satisfaction. An innovative tool is needed in accessing the right information at the right time, especially when spontaneous and urgent decision-making is needed. To this end, the innovative use of a mobile device in delivering information and services to the management team in real-time and based on their current context offers significant benefits. This paper discusses context-aware computing, the enabling technologies for geolocation and the development of a prototype, mobile, context-aware application for construction programme management. The prototype system developed is based on the findings from an earlier study of user requirements which showed that the ability to provide relevant information and services at an appropriate time and at the most appropriate location has the potential to improve the monitoring and control of construction programmes. The prototype system demonstrates the provision of context-specific information and services to construction programme managers using a mobile device. The benefits and limitations of the proposed approach are discussed and conclusions drawn about the potential impact of enhanced information delivery for the efficiency of the construction programme managers

    Planning and implementation of effective collaboration in construction projects

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    The 21st century is now seen as the time for the construction industry to embrace new ways of working if it is to continue to be competitive and meet the needs of its ever demanding clients. Collaborative working is considered by many to be essential if design and construction teams are to consider the whole lifecycle of the construction product. Much of the recent work on collaborative working has focused on the delivery of technological solutions with a focus on web (extranets), CAD (visualisation), and knowledge management technologies. However, it is now recognised that good collaboration does not result from the implementation of information technology solutions alone. The organisational and people issues, which are not readily solved by pure technical systems, need to be resolved. However, approaches that exclusively focus on organisational and people issues will not reap the benefits derived from the use of technology, especially in the context of distributed teams which are the norm in construction. Work currently being undertaken at Loughborough University aims to bring together the benefits enabled by the technology, with the organisational, and its people issues to provide a framework enabling high level strategic decisions to be made to implement effective collaboration. This paper reports on the initial stages of the project: the background to the project, the methodology used, and findings from the literature survey and the requirements capture survey conducted as part of the project

    Reproducibility and repeatability of measuring the electrical impedance of the pregnant human cervix-the effect of probe size and applied pressure

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    Background: The utility of cervical electrical impedance spectroscopy (EIS) as a diagnostic tool is being investigated in clinical trials. We sought to assess the reliability of two different sizes of tetrapolar probes used in measuring cervical impedance. Methods: Cervical transfer impedance was measured at 14 frequencies between 76 and 625 000 Hz from 11 pregnant subjects at term. Repeated measurements were taken with two probes (3 mm and 12 mm diameter) applied softly (approximately 0.7 Newton of force), and firmly (approximately 2.2 Newton) to the surface of the cervix by two observers. The intra-class correlation coefficient (ICC), coefficient of variation (CV) and repeatability standard deviations (SD) were derived from these measurements and compared. Results: Measurements taken by one observer were highly repeatable for both probes as demonstrated by high ICC and low CV values. Probe performance was improved further by firm application. Firm application of the 3 mm probe resulted in ICC values that ranged from 0.936 to 0.986 (p = 0.0001) and CV values between 1.0 and 3.4%. Firm pressure with the 12 mm probe resulted in ICC values that ranged between 0.914 and 0.988 (p = 0.0001) with CV values between 0.7 and 2.1%. In addition, the repeatability SD was low across all frequencies implying that there was low intra-observer variability. Measurements taken by 2 observers with firm application of the 12 mm probe demonstrated moderate reproducibility between 9.8 and 156 kHz, the frequency range in which previous clinical studies have shown predictive association between high cervical resistivity and vaginal delivery: ICC values ranged between 0.528 and 0.638 (p < 0.05), CV values were between 3.3 and 5.2% and reproducibility SD values were also low. In contrast the 3 mm probe demonstrated poor reproducibility at all study frequencies. Conclusion: Measuring cervical resistivity by a single observer with both the 3 and 12 mm probes is highly repeatable whilst inter-observer reproducibility is poor with the 3 mm probe but moderately good when the 12 mm probe is firmly applied to the cervix in the frequency range 9.8 to 156 kHz, consistent with our observations of probe performance in clinical trials

    Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss

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    Background: We have recently shown that serum relaxin-2 levels are attenuated in women with a history of recurrent pregnancy loss (RPL). We sought to determine whether a history of RPL is also associated with changes in serum matrix metalloproteases (MMPs) and tissue inhibitors of matrix metalloproteases (TIMP) -1 and -2. Methods: We obtained serum from 20 pregnant women with a history of RPL and 20 age-matched pregnant women with no history of RPL (NRPL) at 6-8, 10-12, 20, and 34 weeks gestation, and from cord blood. We quantified total serum concentrations of MMP-1, MMP-3, MMP-9 and TIMP-1 and TIMP-2 by ELISA. We determined whether these serum marker levels were associated with a history of RPL and delivery before 37 weeks gestation. Results: There was no difference in the rates of miscarriage, preterm birth or prelabour rupture of fetal membranes between RPL and NRPL. However babies born to RPL were lighter than those born to NRPL. Serum MMP-1, 9, and TIMP-1 did not differ between RPL and NRPL but MMP-3 was higher in RPL vs. NRPL at 6-8 weeks (P < 0.05). Serum TIMP-2 levels were higher in RPL women at all gestations (P < 0.01). The ratio of RLX-2 (reported previously) to TIMP-2 at 10-12 weeks gestation was more strongly associated with a history of RPL than either peptide separately - area under the ROC curves for RLX-2 0.79 (95% CI 0.57 to 0.92), TIMP-2 0.83 (95% CI 0.63 to 0.95), and for RLX-2: TIMP-2 ratio 0.92 (95% CI 0.74 to 0.99). Conclusions: Women with a history of RPL demonstrate increased serum TIMP-2 and reduced RLX-2 during a subsequent viable pregnancy. Determination of both markers in early pregnancy enhances the discrimination of women with a history of RPL. These observations suggest roles for these two peptides in early implantation and placental development. Whether these may prove to be reliable early predictive markers for subsequent pregnancy loss in the index pregnancy is unknown and will require further studies

    Fetal imaging and diagnosis services in developing countries – A call to action

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    Fetal congenital anomalies are among the leading causes of perinatal death or survival with disability worldwide. Their accurate antenatal detection  employing a range of fetal imaging techniques enables parental choices to be made and for postnatal care of affected babies to be planned. While such  prenatal care is well developed in developed countries of the world, it remains poor in many low‑ and middle‑income countries (LMICs). This review article  examines the scope of the problem and proffers strategies for service  organization and fetal imaging that will improve care in LMIC settings.Key words: Congenital abnormalities; fetus; imaging; pregnancy; ultrasound

    Application of GIS to labour market planning in construction

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    The fluctuations in the demand for construction work have often resulted in skills shortages. This has led to the need for effective construction labour market planning strategies, which enable the construction industry to meet its skills requirements, particularly in periods of peak demand. Existing approaches to construction labour market planning have several limitations. They do not shed light on the socio-economic and spatially influenced issues within which the industry’s skills shortages are rooted. There is, therefore, a need for more appropriate decision-support mechanisms that can take account of spatial problems in terms of skills demand and supply influences. Through industry involvement, this research has explored how GIS can enhance the labour market planning process in construction. The research briefly reviews the nature of labour market planning in construction, introduces geographic information systems, and highlights the opportunities they offer for overcoming the limitations of existing approaches. The implementation of the GIS-based system and its application to a specific labour market planning initiative is then presented. The evaluation of the system by prospective end-users reveals the enablers, barriers and benefits of the system implementation. Organisational issues that had a bearing on the implementation are also examined and recommendations made for further research

    Female gut and genital tract microbiota-induced crosstalk and differential effects of short-chain fatty acids on immune sequelae

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    The gut and genital tract microbiota of females represent very complex biological ecosystems that are in continuous communication with each other. The crosstalk between these two ecosystems impacts host physiological, immunological and metabolic homeostasis and vice versa. The vaginal microbiota evolved through a continuous translocation of species from the gut to the vagina or through a mother-to-child transfer during delivery. Though the organisms retain their physio-biochemical characteristics while in the vagina, the immune responses elicited by their metabolic by-products appear to be at variance with those in the gut. This has critical implications for the gynecological, reproductive as well as overall wellbeing of the host and by extension her offspring. The homeostatic and immunomodulatory effects of the bacterial fermentation products (short chain fatty acids, SCFAs) in the gut are better understood compared to the genital tract. While gut SCFAs prevent a leakage of bacteria and bacterial products from the gut in to circulation (leaky gut) and consequent systemic inflammation (anti-inflammatory/protective role); they have been shown to exhibit dysbiotic and proinflammatory effects in the genital tract that can lead to unfavorable gynecological and reproductive outcomes. Therefore, this review was conceived to critically examine the correlation between the female gut and genital tract microbiota. Secondly, we explored the metabolic patterns of the respective microbiota niches; and thirdly, we described the diverse effects of products of bacterial fermentation on immunological responses in the vaginal and rectal ecosystems
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