Interface truth material with prohibition of use of the results of the aircraft accident ivestisation as a tool of evidence

Ratio legis of Article 359 of the aviation law (number 1 of 2009) is results of the investigation is not made for the judicial system but rather aims of improving flight safety and prevent accidents with the same cause. Validating the material truth in aircraft accidents can still be achieved, although the results of the investigation can not use as evidenc

FACTORS AFFECTING THE ADOPTION OF JENIUS IN INDONESIA BASED ON THE UNIFIED THEORY OF ACCEPTANCE AND USE OF TECHNOLOGY MODEL MODIFIED BY THE TECHNOLOGY ACCEPTANCE MODEL CONCEPT

ABSTRACT Along with the increasingly sophisticated and modern variety of technologies, the use of the internet is also increasingly used in various aspects of life and one of them is from banking sector. Nevertheless, the user of banking service is still low compared with internet users itself and smartphone users even it has some features that beneficial for the users. Moreover, it’s also beneficial for the country. This research aims to analyze factors influencing behavioral intention towards adoption of Jenius in Indonesia. Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) Model is used. The data was gathered through an online survey and earned 400 valid respondents who use Jenius for the past six months. All the data gathered has passed the validity and reliability tests. Furthermore, the research hypothesis was tested using Structural Equation Modeling (SEM) on SmartPLS. The result shows Effort Expectancy (EE), Facilitating Conditions (FC), Performance Expectancy (PE), Self-Efficacy (SE), Security (SEC) and Social Influence (SI) have an effect of 47.4% on Hedonic Motivation (HM). Then the Hedonic Motivation (HM) variables, Effort Expectancy (EE), Facilitating Conditions (FC), Performance Expectancy (PE), Self-Efficacy (SE), Security (SEC) and Social Influence (SI) have an effect of 53.6% towards Behavioral Intention (BI). From the analysis, the company suggested to improve socialization and the marketing, improving services so that users can feel comfortable in using the application, maintain the best service to users and improving facilities for users so that they are more interested in adopting the services

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. Aims The study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods Fasting blood samples were collected from consenting Saudi Arabian patients (BMI: 30.2 ± (SD)5.6 kg/m2, n = 413), consisting of non-diabetics (ND: n = 67) and T2DM subjects (n = 346). The diabetics were divided into 5 subgroups based on their 1 year treatment regimes: diet-controlled (n = 36), metformin (n = 141), rosiglitazone (RSG: n = 22), a combined fixed dose of metformin/rosiglitazone (met/RSG n = 100) and insulin (n = 47). Lipid profiles, fasting plasma glucose, insulin, adiponectin, resistin, TNF-α, leptin, C-reactive protein (CRP) and endotoxin concentrations were determined. Results Regression analyses revealed significant correlations between endotoxin levels and triglycerides (R2 = 0.42; p < 0.0001); total cholesterol (R2 = 0.10; p < 0.001), glucose (R2 = 0.076; p < 0.001) and insulin (R2 = 0.032; p < 0.001) in T2DM subjects. Endotoxin showed a strong inverse correlation with HDL-cholesterol (R2 = 0.055; p < 0.001). Further, endotoxin levels were elevated in all of the treated diabetic subgroups compared with ND, with the RSG treated diabetics showing significantly lower endotoxin levels than all of the other treatment groups (ND: 4.2 ± 1.7 EU/ml, RSG: 5.6 ± 2.2 EU/ml). Both the met/RSG and RSG treated groups had significantly higher adiponectin levels than all the other groups, with the RSG group expressing the highest levels overall. Conclusion We conclude that sub-clinical inflammation in T2DM may, in part, be mediated by circulating endotoxin. Furthermore, that whilst the endotoxin and adipocytokine profiles of diabetic patients treated with different therapies were comparable, the RSG group demonstrated significant differences in both adiponectin and endotoxin levels. We confirm an association between endotoxin and serum insulin and triglycerides and an inverse relationship with HDL. Lower endotoxin and higher adiponectin in the groups treated with RSG may be related and indicate another mechanism for the effect of RSG on insulin sensitivity

The role of the non-oil minerals sector in the economic growth of Saudi Arabia

The macroeconomy of Saudi Arabia has been dominated by oil exports which between 1970 and 1995 accounted for more than 85% of total export earnings. Due to the fact that oil is an exhaustible resource, the price of which fluctuates considerably, and is produced in an enclave economy, the Saudi Arabian government had recognised the needs to diversify their economy away from oil as the main source of income. Since the oil price crashed in 1986, the Saudi Arabian government has adopted a new policy to develop non-oil sectors, such as manufacturing, agriculture and more recently, non-oil minerals. The main objective of this study is to evaluate the contribution of the non-oil minerals sector to the economic growth of Saudi Arabia during the period 1970-1995, using three different approaches. These approaches are the export portfolio approach, the input-output approach and the Dutch disease approach. The empirical findings of this study show the following: 1. A non-oil export portfolio analysis provided guidance to the Saudi Arabian planners who seek simultaneously to reduce export earnings instability and achieve economic growth. An increase in the volume of machinery and transport equipment commodities could produce an optimum portfolio due to both price trends and stability of price over time. Other exports, including non-oil mineral commodities, are unstable and have relatively negative price trends. 2. Even though preliminary results indicate that the non-oil minerals sector has a relatively low integration with other sectors, when the impact of inducing final demand is taken into account, this sector shows the highest income and the second highest employment multipliers. These results indicate that if this sector were to be stimulated by increasing final demand, it may well generate more income and employment than other sectors. Therefore, the application of an input-output approach was extended further to estimate the impact of three new promising nonoil mineral projects on the Saudi Arabian economy. Moreover, the construction and operation phase's multipliers reflect the potential of the non-oil minerals sector. 3 With regard to the effect of a boom in one sector of the economy on the rest of the sectors, the oil sector boom in the 1970s in the case of Saudi Arabia conforms very closely with the assumptions of the Dutch disease theory

Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis

Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis. Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures. Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects. Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity

The atherogenic and metabolic impact of non-HDL cholesterol versus other lipid sub-components among non-diabetic and diabetic Saudis

BACKGROUND: Several trials from different populations have reported that non-high density lipoprotein cholesterol (non-HDL-C) has more predictive power than low-density lipoprotein cholesterol (LDL-C) in detecting coronary heart disease (CHD) and none in any Arab community whose propensity to develop CHD is higher compared to other ethnicities. This study aims to determine and compare the impact of non-HDL-C versus other lipid parameters, in predicting coronary heart disease among diabetic versus non-diabetic adult Saudis and identify the lipid parameters which make a significant contribution in the development of coronary heart disease, diabetes mellitus, and metabolic syndrome. 733 adult Saudis were recruited and divided into groups of diabetics and non-diabetics. Each participant completed a questionnaire, underwent physical exam including 12-L ECG, and submitted a fasting blood sample where glucose and lipid parameters were analyzed using routine procedures. RESULTS: 462 subjects (age 45.03 ± 11.52; BMI 28.91 ± 6.07) were classified non-diabetics while the remaining 271 (age 52.73 ± 11.45, BMI 30.15 ± 6.62) were diabetics. 99 out of 465 (21.3%) of non-diabetics had CHD and 114 out of 271 (52.5%) in the diabetics. Non-HDL cholesterol was the best predictor among the non-diabetics (odds-ratio 2.89, CI 1.10–7.58, p-0.03). Total cholesterol was the highest single predictor for the development of CHD among the lipids (odds-ratio 1.36, CI 0.68–2.71, p-0.39) but HDL-cholesterol although small was significant (odds-ratio 0.52, CI 0.27–0.99, p-0.05). CONCLUSION: This study supports the use of non-HDL cholesterol as the more practical and reliable target for lipid lowering therapy among the Saudi population

Circulating leukocyte telomere length is highly heritable among families of Arab descent

Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults. It is not known, however, whether or not telomere length is a highly conserved inheritable trait in this homogeneous cohort, where age-related diseases are highly prevalent. As such, the aim of this study was to address the inheritability of telomere length in Saudi families and the impact of cardiometabolic disease biomarkers on telomere length. Methods A total of 119 randomly selected Saudi families (123 adults and 131 children) were included in this cross-sectional study. Anthropometrics were obtained and fasting blood samples were taken for routine analyses of fasting glucose and lipid profile. Leukocyte telomere length was determined using quantitative real time PCR. Results Telomere length was highly heritable as assessed by a parent-offspring regression [h2 = 0.64 (p = 0.0006)]. Telomere length was modestly associated with BMI (R2 0.07; p-value 0.0087), total cholesterol (R2 0.08; p-value 0.0033), and LDL-cholesterol (R2 0.15; p-value 3 x 10-5) after adjustments for gender, age and age within generation. Conclusion The high heritability of telomere length in Arab families, and the associations of telomere length with various cardiometabolic parameters suggest heritable genetic fetal and/or epigenetic influences on the early predisposition of Arab children to age-related diseases and accelerated ageing

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

Macrophage Fcgamma receptors (FcgammaRs) mediate the uptake and destruction of antibody-coated viruses, bacteria, and parasites. We examined FcgammaR signaling and phagocytic function in bone marrow-derived macrophages from mutant mice lacking the major Src family kinases expressed in these cells, Hck, Fgr, and Lyn. Many FcgammaR-induced functional responses and signaling events were diminished or delayed in these macrophages, including immunoglobulin (Ig)G-coated erythrocyte phagocytosis, respiratory burst, actin cup formation, and activation of Syk, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinases 1 and 2. Significant reduction of IgG-dependent phagocytosis was not seen in hck(-)(/)-fgr(-)(/)- or lyn(-)(/)- cells, although the single mutant lyn(-)(/)- macrophages did manifest signaling defects. Thus, Src family kinases clearly have roles in two events leading to FcgammaR-mediated phagocytosis, one involving initiation of actin polymerization and the second involving activation of Syk and subsequent internalization. Since FcgammaR-mediated phagocytosis did occur at modest levels in a delayed fashion in triple mutant macrophages, these Src family kinases are not absolutely required for uptake of IgG-opsonized particles

The types of bank that influencing the higher fixed deposit return for MD Tampin / Muhammad Hairee Ismail and Sharifah Zainab Qubra Al Attas

Over the few years, Majlis Daerah Tampin had invested their money in fixed deposit account for their future. This study intends to examine which types of bank giving the higher fixed deposit return for Majlis Daerah Tampin. The data ranges from 2008 to 2016 on a quarterly basis which comprises of 31 observation. There are total of three independent variable which are Commercial Bank Fixed Deposit Return, Merchant Bank Fixed Deposit return and Bank Badan Berkanun Fixed Deposit Return and Company Fixed Deposit Return as dependent variable. In the process of findings, the researcher is using Eviews9 statistical tool to generate all the data for analysis purpose. The result shows that Bank Badan Berkanun as the independent variable has significant relationship towards the Company Fixed Deposit Return. This study is done to contribute and information to Majlis Daerah Tampin for their future investment and to enhance public about the fixed deposit account