Response of tantalum capacitors to fast transient overvoltages

Report describes tests used to determine minimum time for capacitors to fail due to overvoltage and maximum amount of overvoltage that capacitors could sustain without permanent damage

ASTP simulated lightning test report

A simulated lightning test was conducted on the backup spacecraft for the Apollo Soyuz Test Project mission (CSM-119) to determine the susceptibility of the Apollo spacecraft to damage from the indirect effects of lightning. It is demonstrated that induced lightning effects from low-level injected currents can be scaled linearly to those which are obtained in a full threat lightning stroke. Test results indicate that: (1) many of the power and signal critical circuits would fail if subjected to full-threat lightning, (2) pyrotechnic circuits are safe for full-threat lightning, and (3) common-mode voltages exceeded the failure criteria level for all but three of the circuits tested

Complete chaotic synchronization in mutually coupled time-delay systems

Complete chaotic synchronization of end lasers has been observed in a line of mutually coupled, time-delayed system of three lasers, with no direct communication between the end lasers. The present paper uses ideas from generalized synchronization to explain the complete synchronization in the presence of long coupling delays, applied to a model of mutually coupled semiconductor lasers in a line. These ideas significantly simplify the analysis by casting the stability in terms of the local dynamics of each laser. The variational equations near the synchronization manifold are analyzed, and used to derive the synchronization condition that is a function of the parameters. The results explain and predict the dependence of synchronization on various parameters, such as time-delays, strength of coupling and dissipation. The ideas can be applied to understand complete synchronization in other chaotic systems with coupling delays and no direct communication between synchronized sub-systems.Comment: 22 pages, 6 figure

Tantalum capacitor behavior under fast transient overvoltages

Tantalum capacitors were tested to determine failure time when subjected to short-duration, high-voltage surges caused by lightning strikes. Lightning is of concern to NASA because of possible damage to critical spacecraft circuits. The test was designed to determine the minimum time for tantalum capacitor failure and the amount of overvoltage a capacitor could survive, without permanent damage, in 100 microseconds. All tested exhibited good recovery from the transient one-shot pulses with no failure at any voltage, forward or reverse, in less than 25 microseconds

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

The epithelial-to-mesenchymal transition enables carcinoma cells to acquire malignancy-associated traits and the properties of tumor-initiating cells (TICs). TICs have emerged in recent years as important targets for cancer therapy, owing to their ability to drive clinical relapse and enable metastasis. Here, we propose a strategy to eliminate mesenchymal TICs by inducing their conversion to more epithelial counterparts that have lost tumor-initiating ability. We report that increases in intracellular levels of the second messenger, adenosine 3',5'-monophosphate, and the subsequent activation of protein kinase A (PKA) induce a mesenchymal-to-epithelial transition (MET) in mesenchymal human mammary epithelial cells. PKA activation triggers epigenetic reprogramming of TICs by the histone demethylase PHF2, which promotes their differentiation and loss of tumor-initiating ability. This study provides proof-of-principle for inducing an MET as differentiation therapy for TICs and uncovers a role for PKA in enforcing and maintaining the epithelial state

The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus

High-quality, well-annotated genome sequences and standardized laboratory strains fuel experimental and evolutionary research. We present improved genome sequences of three species of Saccharomyces sensu stricto yeasts: S. bayanus var. uvarum (CBS 7001), S. kudriavzevii (IFO 1802T and ZP 591), and S. mikatae (IFO 1815T), and describe their comparison to the genomes of S. cerevisiae and S. paradoxus. The new sequences, derived by assembling millions of short DNA sequence reads together with previously published Sanger shotgun reads, have vastly greater long-range continuity and far fewer gaps than the previously available genome sequences. New gene predictions defined a set of 5261 protein-coding orthologs across the five most commonly studied Saccharomyces yeasts, enabling a re-examination of the tempo and mode of yeast gene evolution and improved inferences of species-specific gains and losses. To facilitate experimental investigations, we generated genetically marked, stable haploid strains for all three of these Saccharomyces species. These nearly complete genome sequences and the collection of genetically marked strains provide a valuable toolset for comparative studies of gene function, metabolism, and evolution, and render Saccharomyces sensu stricto the most experimentally tractable model genus. These resources are freely available and accessible through www.SaccharomycesSensuStricto.org

Photo-CIDNP in the reaction center of the diatom Cyclotella meneghiniana observed by 13C MAS NMR

Solid state NMR/Biophysical Organic Chemistr

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2

Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2