Társadalom és építészet peremén: A szociális építészet tervezési aspektusai

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Extending and Enhancing the Existing Motorail (Car Trains) System in the Danube River Basin (Drb)

The aim of the project is the enhancement of a greener, innovative and sustainable mobility through the extension of the existing railway system with as little changes as possible and the development of new modes of transport, providing a fast and seamless combination of rail and water transport, followed by short distance travel to the final destination by motorized vehicles or bicycles. This would be achieved through the extension in the Danube River Basin of the motorail system which allows the transport of cars, motorbikes and small trailers, creating an efficient, seamless and low-carbon transport network, thus contributing to the sustainable development of economic competitiveness and growth, of an integrated European single market and of an open and inclusive society, of tourist accessibility to new countries

A CIBIS III alvizsgálatának eredményei

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Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure

BACKGROUND: -Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. METHODS AND RESULTS: -We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensinconverting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of medical treatment for heart failure (520 versus 604; hazard ratio, 0.84; 95% confidence interval, 0.74-0.94; P=0.003) or an emergency department visit for worsening heart failure (hazard ratio, 0.66; 95% confidence interval, 0.52-0.85; P=0.001). The patients in the LCZ696 group had 23% fewer hospitalizations for worsening heart failure (851 versus 1079; P<0.001) and were less likely to require intensive care (768 versus 879; 18% rate reduction, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001), and to have implantation of a heart failure device or cardiac transplantation (22% risk reduction, P=0.07). The reduction in heart failure hospitalization with LCZ696 was evident within the first 30 days after randomization. Worsening of symptom scores in surviving patients was consistently more common in the enalapril group. LCZ696 led to an early and sustained reduction in biomarkers of myocardial wall stress and injury (N-terminal pro-Btype natriuretic peptide and troponin) versus enalapril. CONCLUSIONS: -Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotensin-converting enzyme inhibition. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255

Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial

BACKGROUND: The prevalence of pre-diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. METHODS AND RESULTS: We examined clinical outcomes in 8399 patients with heart failure and reduced ejection fraction according to history of diabetes mellitus and glycemic status (baseline hemoglobin A1c [HbA1c]: /=6.5% [>/=48 mmol/mol; diabetes mellitus]), in Cox regression models adjusted for known predictors of poor outcome. Patients with a history of diabetes mellitus (n=2907 [35%]) had a higher risk of the primary composite outcome of heart failure hospitalization or cardiovascular mortality compared with those without a history of diabetes mellitus: adjusted hazard ratio, 1.38; 95% confidence interval, 1.25 to 1.52; P6.5%) and known diabetes mellitus compared with those with HbA1c<6.0% was 1.39 (1.17-1.64); P<0.001 and 1.64 (1.43-1.87); P<0.001, respectively. Patients with pre-diabetes mellitus were also at higher risk (hazard ratio, 1.27 [1.10-1.47]; P<0.001) compared with those with HbA1c<6.0%. The benefit of LCZ696 (sacubitril/valsartan) compared with enalapril was consistent across the range of HbA1c in the trial. CONCLUSIONS: In patients with heart failure and reduced ejection fraction, dysglycemia is common and pre-diabetes mellitus is associated with a higher risk of adverse cardiovascular outcomes (compared with patients with no diabetes mellitus and HbA1c <6.0%). LCZ696 was beneficial compared with enalapril, irrespective of glycemic status. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255

Urban Integration of an Oldtown District At-Risk of Segregation in Dombóvár

The urban structure of Dombóvár has been transformed in recent centuries, and the protected buildings that once defined the town center, have been relegated to the periphery. Today, despite its rich architectural heritage, the Kakasdomb district is an area at risk of segregation. The key to the integration of the district into the existing urban tissue is the utilization of the protected buildings of the area including the former synagogue building. This paper examines the possibilities for the reuse of the synagogue based on the town development strategy and the perceptions of the remaining Jewish community, and the systematic modification of the settlement structure, together with the possibilities for the integration of the neighborhood

Investigation of geometrically necessary dislocation structures in compressed Cu micropillars by 3-dimensional HR-EBSD

Mechanical testing of micropillars is a field that involves new physics, as the behaviour of materials is non-deterministic at this scale. To better understand their deformation mechanisms we applied 3-dimensional high angular resolution electron backscatter diffraction (3D HR-EBSD) to reveal the dislocation distribution in deformed single crystal copper micropillars. Identical micropillars (6 μm μm μm in size) were fabricated by focused ion beam (FIB) and compressed at room temperature. The deformation process was stopped at different strain levels ( , and ) to study the evolution of geometrically necessary dislocations (GNDs). Serial slicing with FIB and consecutive HR-EBSD mapping on the (100) side was used to create and compare 3-dimensional maps of the deformed volumes. Average GND densities were calculated for each deformation step. Total dislocation density calculation based on X-ray synchrotron measurements were conducted on the pillar to compare dislocation densities determined by the two complementary methods. Scanning transmission electron microscopy (STEM) and transmission electron microscopy (TEM) images were captured on the pillar to visualize the actual dislocation structure. With the 3D HR-EBSD technique we have studied the geometrically necessary dislocations evolving during the deformation of micropillars. An intermediate behaviour was found at the studied sample size between bulk and nanoscale plasticity: A well-developed dislocation cell structure built up upon deformation but with significantly lower GND density than in bulk. This explains the simultaneous observation of strain hardening and size effect at this scale

Caprock analysis from the Mihályi-Répcelak natural CO2 occurrence, Western Hungary

Caprock integrity is one of the most important factors regarding the long-term safe underground storage of CO2. As a result of geochemical reactions among the caprock mineralogy and CO2 saturated pore water, the physical properties of caprock such as porosity, permeability may change, which could affect its sealing capacity. Natural CO2 occurrences can help to understand these long term reactions under storage conditions on geological timescale. Our study area, the Miha´lyi-Re´pcelak natural CO2 occurrence, is believed to be leak-proof system on geological timescale. To identify and understand the mineral reactions in the caprocks we applied XRD, FTIR-ATR and SEM analysis of drill cores derived from the study area. The petrophysical properties of the studied rock samples were determined from the interpretation of geophysical well-logs and grain size distribution. The effective porosity (*4 %), permeability (0.026 mD) and clay content(*80 %) of the drill cores imply that the studied clayey caprocks represent an adequate physical barrier to the CO2. Our analytical results show that dawsonite has formed within the caprocks. In most cases the dawsonite crystallized after albite dissolution. This implies that CO2 or CO2-saturated brine can penetrate into the caprock resulting in mineral reactions and most likely changing the porosity and permeability of the sealing lithology. On the other hand the caprock may react as a geochemical buffer for the CO2 and, at least part of it, can be stored within the caprock as solid phase, thereby increasing the storage capacity of the system