Data De-Duplication with Adaptive Chunking and Accelerated Modification Identifying

The data de-duplication system not only pursues the high de-duplication rate, which refers to the aggregate reduction in storage requirements gained from de-duplication, but also the de-duplication speed. To solve the problem of random parameter-setting brought by Content Defined Chunking (CDC), a self-adaptive data chunking algorithm is proposed. The algorithm improves the de-duplication rate by conducting pre-processing de-duplication to the samples of the classified files and then selecting the appropriate algorithm parameters. Meanwhile, FastCDC, a kind of content-based fast data chunking algorithm, is adopted to solve the problem of low de-duplication speed of CDC. By introducing de-duplication factor and acceleration factor, FastCDC can significantly boost de-duplication speed while not sacrificing the de-duplication rate through adjusting these two parameters. The experimental results demonstrate that our proposed method can improve the de-duplication rate by about 5 %, while FastCDC can obtain the increase of de-duplication speed by 50 % to 200 % only at the expense of less than 3 % de-duplication rate loss

Differential expression profiling between the relative normal and dystrophic muscle tissues from the same LGMD patient

BACKGROUND: Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or primarily involved. Although analysis of the defective proteins has shed some light onto their functions implicated in the etiology of LGMD, our understanding of the molecular mechanisms underlying muscular dystrophy remains incomplete. METHODS: To give insight into the molecular mechanisms of AR-LGMD, we have examined the differentially expressed gene profiling between the relative normal and pathological skeletal muscles from the same AR-LGMD patient with the differential display RT-PCR approach. The research subjects came from a Chinese AR-LGMD family with three affected sisters. RESULTS: In this report, we have identified 31 known genes and 12 unknown ESTs, which were differentially expressed between the relative normal and dystrophic muscle from the same LGMD patient. The expression of many genes encoding structural proteins of skeletal muscle fibers (such as titin, myosin heavy and light chains, and nebulin) were dramatically down-regulated in dystrophic muscles compared to the relative normal muscles. The genes, reticulocalbin 1, kinectin 1, fatty acid desaturase 1, insulin-like growth factor binding protein 5 (IGFBP5), Nedd4 family interacting protein 1 (NDFIP1), SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2), encoding the proteins involved in signal transduction and gene expression regulation were up-regulated in the dystrophic muscles. CONCLUSION: The functional analysis of these expression-altered genes in the pathogenesis of LGMD could provide additional information for understanding possible molecular mechanisms of LGMD development

Recyclable and Robust Optical Nanoprobes with Engineered Enzymes for Sustainable Serodiagnostics

Recyclable fluorescence assays that can be stored at room temperature would greatly benefit biomedical diagnostics by bringing sustainability and cost-efficiency, especially for point-of-care serodiagnostics in developing regions. Here, a general strategy is proposed to generate recyclable fluorescent probes by using engineered enzymes with enhanced thermo-/chemo-stability, which maintains an outstanding serodiagnostic performance (accuracy >95%) after 10 times of recycling as well as after storage at elevated temperatures (37 °C for 10 days). With these three outstanding properties, recyclable fluorescent probes can be designed to detect various biomarkers of clinical importance by using different enzymes

Multi‐Channel Lanthanide Nanocomposites for Customized Synergistic Treatment of Orthotopic Multi‐Tumor Cases

Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused by individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment of multiple subcutaneous orthotopic tumors under non-uniform whole-body infrared irradiation prescription. The nanocomposite reduces intratumoral glutathione by simultaneously activating the fluorescence and photothermal channels. The fluorescence provides individual information on different tumors, allowing customized prescriptions to be made. This enables optimal induction of hyperthermia and dosage of chemo drugs, to ensure treatment efficacy, while avoiding overtherapy. With an accessional therapeutic laser system, customized synergistic treatment of subcutaneous orthotopic cancer cases with multiple tumors is possible with both high efficacy and minimized side effects

Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites

The photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength-dependent optical attenuation properties of tissues, the tumor depth is assessed using a multichannel lanthanide nanocomposite. A zeolitic imidazolate framework (ZIF-8)-coated nanocomposite is able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen-bonding network formed by the encapsulated highly polarized polyoxometalate guest. It is superior to both bare and PEGylated ZIF-8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues

Experimental Investigation of Diagram Equilibria in the Co-Nb-Re Ternary System

Abstract(#br)In this study, the isothermal sections of the Co-Nb-Re ternary system at 1200, and 1300 °C have been experimentally determined combining the means of electron probe microanalysis (EPMA) and x-ray diffraction (XRD). The obtained experimental results showed that: (1) The Laves phase of λ3-Co2Nb (C36) was stable at 1300 °C. The temperature was beyond its stability limit in Co-Nb binary system. (2) The solubility of Re in the λ3 phase was so large that the nearest λ2-Co2Nb (C15) phase was essentially surrounded. (3) The solubility of Re in the μ-Co7Nb6 phase was 34.0 at.% at 1200 °C and 35.2 at.% at 1300 °C, respectively. (4) The liquid phase existed at 1300 °C dissolving about 4.0 at.% Re, but it was..

On Bernstein inequalities for multivariate trigonometric polynomials in LpL_{p}, 0≤p≤∞0\leq p\leq \infty

summary:Let ${\mathbb T}_n$ be the space of all trigonometric polynomials of degree not greater than $n$ with complex coefficients. Arestov extended the result of Bernstein and others and proved that $\| (1/n) T'_n \|_{p} \leq \| T_n \|_{p}$ for $0 \leq p \leq \infty$ and $T_n \in {\mathbb T}_n$. We derive the multivariate version of the result of Golitschek and Lorentz $$\Bigl \| \Bigl | T_n \cos \alpha + \frac {1}{n} \nabla T_n \sin \alpha \Bigr |_{l_{\infty }^{(m)}} \Bigr \|_{p} \leq \| T_n \|_{p}, \quad 0 \leq p \leq \infty$$ for all trigonometric polynomials (with complex coeffcients) in $m$ variables of degree at most $n$