Baugeschichte der Pfarrkirche in Dornbach

Die Dornbacher Pfarrkirche am Rupertusplatz im 17. Wiener Gemeindebezirk ist den Heiligen Peter und Paul geweiht. Ihre gegenwärtige Gestalt ist das Ergebnis aus zahlreichen Umbauarbeiten und Erweiterungen der letzten Jahrhunderte. Von einer romanischen Kapelle ist leider nichts erhalten, Der älteste Bauteil ist der ehemalige 5/8 Chorschluss, der im Osten eines quadratischen Kirchenschiffs liegt. Diese alte Kirche wurde in den 1930er Jahren nach Süden erweitert und um 90 Grad gedreht. In der vorliegenden Arbeit werden die einzelnen Bauphasen untersucht und ein großer Bestand an erhaltenen Plänen ausgewertet. Es kann festgestellt werden, dass entgegen der bisherigen Forschungslage schon vor dem 18. Jahrhundert eine Erweiterung der alten Kirche Richtung Süden bestanden hat. Es lässt sich jedoch schwer bis gar nicht nachweisen, wann die Kirche erstmals umgebaut wurde. Im Zusammenhang damit kann auch ihr Aussehen im Mittelalter nicht genau rekonstruiert werden. Die Pläne für die Vergrößerung um die Mitte des 18. Jahrhunderts stammen nicht, wie bisher angenommen, von Pater Roman de Champs, dieser hat lediglich ein Projekt vorgelegt, das nicht realisiert wurde. Die jüngste große Erweiterung erfolgte 1931 nach Plänen des österreichischen Architekten Clemens Holzmeister, der in Dornbach ein Konzept verwirklichte, dass an weiteren seiner Kirchenbauten der Zwischenkriegszeit Anwendung gefunden hat. Spätere Umbauarbeiten veränderten Holzmeisters Konzept, das in dieser Arbeit erläutert und ansatzweise rekonstruiert wird. Dafür werden die wertvollen Pläne Holzmeisters und alte Aufnahmen der Kirche herangezogen. Nicht realisierte Projekte der 1990er Jahre beinhalten die Wiederherstellung des, nach Holzmeister ursprünglich geplanten, Kirchenbaus. Vielleicht dienen diese Pläne in der Zukunft als Vorlage für weitere Rekonstruktionsmaßnahmen oder Umbauarbeiten. In der vorliegenden Arbeit konnten einige Fragen geklärt werden, einige müssen vorerst offen bleiben. Die Baugeschichte der Dornbacher Pfarrkirche ist jedenfalls eine spannende Reise durch mehrere Epochen hindurch

Ökologische und ökonomische Bewertung des Ressourcenaufwands – Industrie-4.0-Retrofit-Maßnahmen an Werkzeugmaschinen

ÖKOLOGISCHE UND ÖKONOMISCHE BEWERTUNG DES RESSOURCENAUFWANDS – INDUSTRIE-4.0-RETROFIT-MASSNAHMEN AN WERKZEUGMASCHINEN Ökologische und ökonomische Bewertung des Ressourcenaufwands – Industrie-4.0-Retrofit-Maßnahmen an Werkzeugmaschinen / Zettl, Elisabeth (Rights reserved) ( -

Using boundary objects to make students brokers across disciplines: A dialogue between students and their lecturers on Bertolini’S node-place model

The competencies required for steering urban development sustainably are scattered amongst various disciplines. This is particularly relevant for planners working at the interface of different sub-disciplines, such as transport and land-use planning, exemplified by transit-oriented development (TOD). In this paper, we use Bertolini’s node-place model (NPM) example for TOD to test whether it enables interdisciplinary work to be undertaken in planning education. We tested our hypothesis in two design studios by challenging urban design students to develop their own design brief based on an NPM. The paper is of a dialogic, discursive nature. Students discuss whether or not the NPM enables them to better understand the relationship between transit and urban development and to develop spatial strategies based upon an integrative approach. Our discussion reveals that the NPM cannot necessarily bridge disciplinary boundaries successfully. However, both lecturers and students see value in the model as a didactic instrument

Assessment of microRNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis

Abstract Recent large-scale association studies have identified over 100 MS risk loci. One of these MS risk variants is single-nucleotide polymorphism (SNP) rs17066096, located 14 kb downstream of IL22RA2. IL22RA2 represents a compelling MS candidate gene due to the role of IL-22 in autoimmunity; however, rs17066096 does not map into any known functional element. We assessed whether rs17066096 or a nearby proxy SNP may exert pathogenic effects by affecting microRNA-to-mRNA binding and thus IL22RA2 expression using comprehensive in silico predictions, in vitro reporter assays, and genotyping experiments in 6,722 individuals. In silico screening identified two predicted microRNA binding sites in the 3′UTR of IL22RA2 (for hsa-miR-2278 and hsamiR-411-5p) encompassing a SNP (rs28366) in moderate linkage disequilibrium with rs17066096 (r 2 =0.4). The binding of both microRNAs to the IL22RA2 3′UTR was confirmed in vitro, but their binding affinities were not significantly affected by rs28366. Association analyses revealed significant Electronic supplementary material The online version of this articl

Multiple Sklerose Therapie Konsensus Gruppe (MSTKG): Positionspapier zur verlaufsmodifizierenden Therapie der Multiplen Sklerose 2021 (White Paper)

Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particularly German-speaking countries (Germany, Austria, Switzerland)

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these loci are novel MS susceptibility loci. They map to the genes L3MBTL3, MAZ, ERG, and SHMT1. The lead variant at SHMT1 was replicated in an independent Sardinian cohort. Products of the genes L3MBTL3, MAZ, and ERG play important roles in immune cell regulation. SHMT1 encodes a serine hydroxymethyltransferase catalyzing the transfer of a carbon unit to the folate cycle. This reaction is required for regulation of methylation homeostasis, which is important for establishment and maintenance of epigenetic signatures. Our GWAS approach in a defined population with limited genetic substructure detected associations not found in larger, more heterogeneous cohorts, thus providing new clues regarding MS pathogenesis

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Multiple sclerosis is a complex neurological disease, with 3c20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that much of the remaining heritability is also due to additive effects of common variants rather than epistasis between these variants or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that up to 5% of this heritability is explained by low-frequency variation in gene coding sequence. We identify four novel genes driving MS risk independently of common-variant signals, highlighting key pathogenic roles for regulatory T cell homeostasis and regulation, IFN\u3b3 biology, and NF\u3baB signaling. As low-frequency variants do not show substantial linkage disequilibrium with other variants, and as coding variants are more interpretable and experimentally tractable than non-coding variation, our discoveries constitute a rich resource for dissecting the pathobiology of MS. In a large multi-cohort study, unexplained heritability for multiple sclerosis is detected in low-frequency coding variants that are missed by GWAS analyses, further underscoring the role of immune genes in MS pathology

Quality assurance of compost and digestate

Establishing a quality assurance system for compost and digestate from bio-waste can help to decrease the amount of biodegradable waste being landfilled and to increase material recycling. Germany has been successfully operating such a system since 1989, comprising also an organisation with the competence to control the quality of compost and digestate and to award a quality label, the Bundesgütegemeinschaft Kompost e.V. This brochure introduces to the quality assurance system of compost and digestate in Germany. It provides information, inter alia, on the legal framework related to bio-waste in the EU and in Germany, on involved organisations and on requirements

Using boundary objects to make students brokers across disciplines - a dialogue between students and their lecturers on Bartolini’s node-place-model and interdisciplinarity

Book of proceedings: Annual AESOP Congress, Spaces of Dialog for Places of Dignity, Lisbon, 11-14th July, 2017Competencies required for steering urban development sustainably are scattered among various disciplines. Most prominently, this has been acknowledged by the growing community of planners in the field of transportation and urban development promoting an integrative approach known as transitoriented development (TOD). Disciplinary traditions including different ways of thinking and doing as well as a strong vertical organisation of public administration form major obstacles for TOD and other interdisciplinary approaches to urban development. The implementation of TOD principles in plans and planning policy is usually dependent on strong actors brokering across disciplinary and departmental boundaries (Thomas and Bertolini, 2017: 145). “Boundary objects” (Wenger 2000) can help sustaining the effort of individuals promoting integrative planning approaches against institutional and disciplinary rigidness. These objects allow practitioners of different disciplines to discuss common challenges without constant guidance of experts in multiple disciplinary fields. The development of boundary objects is therefore crucial in order to support current “brokers” (ibid.) and provide continuity when brokers are unavailable. We believe that the node-place-model (NPM) by Bertolini (1999) can be such a boundary object. We test our hypothesis as part of two design studio courses confronting urban design students with the task of developing their own design brief based on a node-place-analysis – a systematic quantification of both accessibility and activity at transit stations. We conducted the course twice while testing our approach on two scales: a city-wide node-place-analysis of the City of Munich with the goal of designing a small city quarter and a node-place-analysis of the entire metropolitan region of Munich with the goal of developing a spatial strategy for the City of Ingolstadt, a key economic node within the metropolitan region. The paper is of dialogic, discursive nature. The lecturers and the students discuss whether or not the node-place-model enables us to understand better the relationship between transit and urban development and to develop spatial strategies based upon an integrative approach. Our discussion reveals that the node-place-model, despite of or perhaps due to its compelling simplicity, cannot necessarily bridge disciplinary boundaries successfully. The model does not comprise mechanisms about how both domains are qualitatively linked. It simplifies node and place into quantitative variables without providing sufficient guidance on operationalisation. Operationalising the model is often subject to misinterpretation. The schematic quantitative nature of the model incites users to blindly apply calculated results. We therefore reject our hypothesis and conclude that the node-place-model may not be suitable as a boundary object in planning practice. Due to above mentioned shortcoming, it cannot serve as a common tool across disciplinary boundaries. However, both lecturers and students see value in the model as a didactic instrument. It initiates food for thought during a discursive process that may lead students to become brokers across domains. The model forces students to connect and integrate knowledge of multiple domains. It raises awareness for the pitfalls of interdisciplinary issues, but at the same time also enforces a critical stance on simplified quantitative implementations.of multiple domains. It raises awareness for the pitfalls of interdisciplinary issues, but at the same time also enforces a critical stance on simplified quantitative implementations.Published versio