Need to strengthen the patent protection of an invention for a process in China

The article submits that protection for a patent for a process invention is incomplete in China in that it does not protect the product prepared by the process. The question of extending the scope of protection to pharmaceuticals and chemical substances is under consideration in China and the writer argues that a first step which should be taken is to extend the protection for process inventions to the products thereof.

An analysis of patent applications in China (1985-1987)

The article analyses the patent applications received at the Chinese Patent Office since its opening. Japan and the United States are the major sources of foreign applications and the ten most popular sub-sections of the IPC to which the applications pertain are identified.

Fully automated biometry of in situ intraocular lenses using long scan depth spectral-domain optical coherence tomography

Spectral-domain optical coherence tomography (SD-OCT) was used to automatically measure accommodative biometric changes in the anterior segment of eyes implanted with an intraocular lens (IOL). The repeatability and reliability of the automated measurements were also evaluated. Long scan depth SD-OCT was used to image the anterior segment of eyes implanted with IOLs. A fully automated algorithm was used to detect the boundaries of the cornea and IOL and yielded the measurements. The results included anterior segment dimensions in IOL eyes and the deflection of the IOLs. Automated measurements were validated in vitro and compared with the manual results in vivo on 15 cross-sectional images from patients with IOLs. Five eyes with five different types of IOLs, respectively, were enrolled to test the repeatability of the automated measurements during accommodation. Intraocular lens central thickness and anterior and posterior curvature radii measured by long scan depth SD-OCT in vitro and in a model eye matched well with those determined by a micrometer caliper and interferometer. In vivo, there was good correlation of the biometric data determined by automated and manual segmentations (P0.05). Anterior chamber depth and pupil diameter showed significant changes between the nonaccommodative and 2.5-D accommodative states (P0.05). The long scan depth SD-OCT with the automated algorithm was verified to have a great potential in studying accommodative biometric changes of the anterior segment in eyes with IOLs and IOL deflections

miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression

Dysregulation of miRNAs in chondrocytes has been confirmed to participate in osteoarthritis (OA) progression. Previous study has screen out several key miRNAs may play crucial role in OA based on bioinformatic analysis. Herein, we identified the downregulation of miR-1 in OA samples and inflamed chondrocytes. The further experiments revealed that miR-1 played an essential role in maintaining chondrocytes proliferation, migration, antiapoptosis, and anabolism. Connexin 43 (CX43) was further predicted and confirmed to be the target of miR-1, and mediated the promotion effects of miR-1 in regulating chondrocyte functions. Mechanistically, miR-1 maintained the expression of GPX4 and SLC7A11 by targeting CX43, attenuated the accumulation of intracellular ROS, lipid ROS, MDA, and Fe2+ in chondrocytes, thereby inhibiting the ferroptosis of chondrocytes. Finally, experimental OA model was constructed by anterior cruciate ligament transection surgery, and Agomir-1 was injected into the joint cavity of mice to assess the protective effect of miR-1 in OA progression. Histological staining, immunofluorescence staining and Osteoarthritis Research Society International score revealed that miR-1 could alleviate the OA progression. Therefore, our study elucidated the mechanism of miR-1 in OA in detail and provided a new insight for the treatment of OA