Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: a follow-up data for mortality

Objective: Heart failure (HF) is a progressive clinical syndrome. SELFIE-TR is a registry illustrating the overall HF patient profile of Turkey. Herein, all-cause mortality (ACM) data during follow-up were provided. Methods: This is a prospective outcome analysis of SELFIE-TR. Patients were classified as acute HF (AHF) versus chronic HF (CHF) and HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction, and HF with preserved ejection fraction and were followed up for ACM. Results: There were 1054 patients with a mean age of 63.3±13.3 years and with a median follow-up period of 16 (7–17) months. Survival data within 1 year were available in 1022 patients. Crude ACM was 19.9% for 1 year in the whole group. ACM within 1 year was 13.7% versus 32.6% in patients with CHF and AHF, respectively (p<0.001). Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta blocker, and mineralocorticoid receptor antagonist were present in 70.6%, 88.2%, and 50.7%, respectively. In the whole cohort, survival curves were graded according to guideline-directed medical therapy (GDMT) scores ?1 versus 2 versus 3 as 28% versus 20.2% versus 12.2%, respectively (p<0.001). Multivariate analysis of the whole cohort yielded age (p=0.009) and AHF (p=0.028) as independent predictors of mortality in 1 year. Conclusion: One-year mortality is high in Turkish patients with HF compared with contemporary cohorts with AHF and CHF. Of note, GDMT score is influential on 1-year mortality being the most striking one on chronic HFrEF. On the other hand, in the whole cohort, age and AHF were the only independent predictors of death in 1 yea

Retinal nerve fiber layer analysis in obstructive sleep apnea

Amaç: Obstrüktif uyku apne sendromu (OUAS) hastalarını retina sinir lifi tabakası (RSLT) kalınlıkları yönünden incelemek ve oküler değişikliklerin hastalığın şiddeti ile ilişkisini belirlemek. Gereç ve Yöntem: OUAS tanılı 54 hasta göz bulguları açısından değerlendirildi. Respiratory Disturbance Index-Anormal Solunum Olayı İndeksi (RDI) 5-29 olan 21’i grup 1, RDI>29 olan 33’ü ise grup 2 kapsamında sınıflandırıldı. Hastalara Optik Koherens Tomografi (OKT) ile RSLT ölçümleri yapıldı. Gruplar elde edilen veriler açısından karşılaştırılırken, verilerin RDI, ortalama ve minimum O2 satürasyonu ile olan ilişkileri de incelendi. Bulgular: Ortalama RSLT grup 1’de 117,33±7,57 μm, grup 2’de ise 111,91 ±8,64 μm olarak ölçüldü. RSLT’deki incelme istatistiksel olarak anlamlı bulundu (p=0,023). İnferior RSLT grup 1’de 147,95 ±12,97 μm, grup 2’de 137,27±17,94 μm olarak bulundu. Grup 2’deki incelme istatistiksel olarak anlamlı bulundu (p=0,032). Ortalama RSLT ile RDI arasında negatif korelasyon saptandı . Sonuç: OUAS hastalarında RSLT kalınlığında azalma meydana gelmekte ve bu değişimler OUAS’ın ağırlığı ile korelasyon göstermektedir. Bu iki durum arasındaki ilişkinin bilinmesi hastaların öncelikle göz hekimi tarafından görüldüklerinde olası OUAS semptomları yönünden sorgulanmalarına olanak sağlayacaktır.Objective: To investigate the retinal nerve fiber thickness (RNFL) in patients with Obstructive sleep apnea syndrome (OSAS) and to determine the correlation of ocular changes with the severity of disease. Material and Methods: 21 patients with Respiratory Disturbance Index (RDI) between 5-29 were included in group 1 and 33 patients with RDI > 29 in group 2. Patients received RNFL measurement with optical coherence tomography (OCT). The difference between the groups and the correlation of RFNL with RDI, mean and minimum O2 saturation was evaluated. Results: The mean RNFL was 117.33±7.57 in group 1, 111.91 ±8.64 μm in group2. There was statistically significant difference (p=0.023). RNFL in inferior quadrant was 147.95 ±12.97 for group 1, 137.27±17.94 μm for group 2. The difference was statistically significant (p=0.032). Mean RNFL was correlated with RDI. Conclusion: There is a significant decreare in RFNL occur in patients with OSAS and changes show correlation with severity of disease. Awareness of relationship helps ophthalmologists to question their patients in terms of OSAS symptoms

Miyopik lasık cerrahi öyküsü olan travmatik afakik gözde göziçi lens gücünün hesaplanması: Olgu sunumu

A fi fty years old female patient with the history of Laser in situ keratomileusis (LASIK) presented at emergency room complaining of insertion of a hair clip piece into her left eye. On slit-lamp examination, there was a foreign body impacted in inferotemporal paracentral cornea extending into the lens via penetrating iris. Two and a half months after the corneal fi xation and traumatic cataract extraction, iridoplasty and secondary intraocular lens (IOL) implantation were applied. The stable refraction was – 0.50 – 0.75/160 degrees at the fi rst year of trauma. In traumatic aphakic eyes with the history of refractive surgery choosing appropriate IOL calculation formula may become more diffi cult because routinely used methods to calculate IOL power do not guarantee the same accuracy compared with naive eyes. Haigis-L formula might be a preferable method to calculate IOL power for these eyes.Geçirilmiş Laser in situ keratomileusis (LASIK) öyküsü olan 50 yaşında kadın hasta sol gözüne saç tokası parçası gelme şikayeti ile acil servise başvurdu. Biyomikroskopik incelemesinde alt temporal parasantral korneadan irisi penetre ederek lense uzanan yabancı cisim izlenmekteydi. Korneal sütürasyon ve travmatik katarakt ekstraksiyonundan 2,5 ay sonra hastaya iridoplasti ve sekonder göziçi lens implantasyonu uygulandı. Travmanın birinci yılında stabil refraksiyon -0.50 -0.75/160 derece düzeyinde idi. Refraktif cerrahi öyküsü olan travmatik afakik hastalarda uygun göziçi lens formülasyonunun seçilmesi rutinde kullanılan diğer yöntemlerin naif gözlerdeki doğruluğu garanti etmemesi nedeniyle zordur. Haigis-L formülünün bu gözler için tercih edilebilir bir yöntem olabileceği düşünülmektedir

Hidrojen Peroksit ile Korunmuş Sütlerin ve Bu Sütlerden Elde Edilen Teleme, Beyaz Peynir ve Peyniralt ı Suları n ı n Toplam Bakteri, Koliform Grubu Mikroorganizmalar ve Maya-Küf İ çeriğinde Meydana Gelen Değişimler

Hidrojen peroksitin süt ve bundan elde edilen teleme, peynir ve peyniralt ı suları nda toplam bakteri, koliform grubu mikroorganizmalar ve maya-küf içeri ğine etkisini belirlemek amac ı yla bu çal ışma gerçekleştirilmiştir. Bunun için, 30±1°C s ı cakl ığı ndaki çiğ süt 4 eşit k ı sma ayr ı lmış ve i çiğ , ii % 0,02, ili % 0,10 ve iv % 0,30 düzeylerinde hidrojen peroksit ilave edilmi ş olarak 4 saat bekletildikten sonra Beyaz peynire i şlenmiştir. Daha sonra kullan ı lan hidrojen peroksitin, süt ve peynirde toplam bakteri, koliform ve maya-küf içeri ği üzerine olan etkisini izlemek üzere, ba şlang ı ç ve 4. saat sütleriyle, 0., 4., 8., ve 12. hafta peynirlerinin mikrobiyolojik analizleri yap ı lmışt ı r. Ayn ı analizler teleme ve peyniralt ı suları nda da gerçekleştirilmiştir. Hidrojen peroksit uygulamas ı n ı n, sütte bulunan toplam bakteri, koliform ve maya-küf üzerinde ilk dört saat içerisinde , kullan ı lan miktara bağı ml ı şekilde bir redüksiyona neden oldu ğu tespit edilmiştir. Kontrol örneğinin an ı lan bakteri bak ı mı ndan h ı zl ı bir art ış ortaya koyduğu gözlenmiştir. Teleme ve peyniralt ı suyu örneklerinin belirtilen mikroorganizma içeri ği de, yine kat ı lan hidrojen peroksit miktar ı ndaki art ışa bağl ı olarak düşme göstermiştir. Peynirlerin olgunla şmas ı sı ras ı nda an ı lan mikroorganizma gruplar ı n ı n, hidrojen peroksitle işlem görmüş olmaktan dolay ı , kontrol peynirindeki değerlerden daha az düzeye indiği belirlenmiştir

Effect of hemifacial spasm intraocular pressure measurement

WOS: 000425412900001PubMed ID: 29545951Purpose. To evaluate the effect of hemifacial spasm (HFS) on intraocular pressure (IOP) measurement. Methods. Twenty-four consecutive patients with HFS and 25 age-and gender-matched randomly selected eyes of healthy volunteers underwent corneal pachymetry and IOP measurements using Goldmann applanation tonometer (GAT) and noncontact tonometer (NCT). IOP measurements were performed before (during HFS) and 2 weeks after Botox injections in HFS patients and in healthy volunteers without Botox injections. Results. There was no statistical difference between involved eye side and uninvolved eye side of HFS patients in measured central corneal thickness. Similarly, no difference was found between involved eye side of HFS patients and controls. There were no statistically significant differences comparing IOP values before treatment and levels measured at 2 weeks of Botox injections, either with GAT (p = 0 33, 0.11) or NCT (p = 0 80, 0.43) devices in the involved eyes and uninvolved eyes of patients with HFS, respectively. There were also no significant differences in these parameters (GAT (p = 0 63) and NCT (p = 0 54)) in controls. Conclusions. Contractions in facial muscles may not lead to significant increase in IOP in HFS patients. This result may help clinical decision making in the treatment of glaucoma patients with HFS. This trial is registered with NCT03390803

Eye Injuries from Pencil Lead: Three Cases

Corneal stromal and/or penetrating ocular injuries from pencils and pencil lead are more common in childhood and may lead to intraocular infection or severe intraocular sterile inflammatory reaction. Herein we report 3 children with ocular trauma due to pencil lead injuries. The first case had corneal stromal injury caused by a pencil. In the second case, a pencil perforated the cornea and contacted the iris. In the third case, pencil lead perforated both the cornea and iris and reached the vitreous through the lens zonules. Intracameral triamcinolone (2 mg/0.05 mL) was injected after the pencil lead was removed from the eyeball. Topical anti-inflammatory and cycloplegic drops were prescribed. In conclusion, corneal and especially penetrating ocular injuries from pencil lead may have a good prognosis with the use of appropriate anti-inflammatory and prophylactic antibiotic treatment and follow-up

Prolonged Harvest Time on Amniotic Cell Culture: Is it Offer Important in Prediction of Fetuses with Trisomies?

OBJECTIVE: In this study, it was objected to investigate the difference in harvest time of amniotic fluids obtained at amniocentesis of normal and trisomic fetuses. STUDY DESIGN: 113 samples of amniotic fluid were obtained at amniocentesis procedures carried out for several indications at Necmettin Erbakan University Meram Faculty of Medicine, Obstetrics and Gynecology Department between August 2010 to August 2011. Harvest time on amniotic cell culture was both evaluated and compared in 100 samples with normal genetic results and 13 samples with trisomy results. RESULTS: There were no statistically significant differences between normal and trisomic groups regarding age, gravidity, parity, and gestational week at amniocentesis (p>0.05). Mean harvest time in cultures of amniotic fluids obtained from genetically normal fetuses was 15.84±2.12 days (12-22 days), whereas it was 15.80± 2.47 days (13-20 days) in cultures of amniotic fluids obtained from trisomic gestations. There was no statistically significant difference between groups regarding intervals to harvest. CONCLUSION: In this study, initial hypothesis was that there may be a possible association of prolonged harvest time with trisomic chromosomal aberrations. Our results concluded that harvest time does not differ between normal and trisomic amniotic fluid cultures