The Destination

It is sometimes difficult to realize that you are making progress, especially in medical school. You fight your way through the dark woods, getting scratched by loose branches, not quite sure if your feet are pointed in the right direction. Sometimes the journey feels like the mountain is collapsing, your feet are falling under you, your fingers throb from frost bite. Yet, there are the days where you stop and see the beauty of the journey in front of you. The winter is not always a cold, barren place, it holds so much beauty and it is worth the fight to continue

PEMBELAJARAN LUKIS TOTEBAG PADA MATA PELAJARAN SENI BUDAYA DI KELAS X MIA 3 SMA NEGERI 3 BOYOLALI TAHUN AJARAN 2017/2018

ABSTRAK Muhammad Fahmi Al Amiq. PEMBELAJARAN LUKIS PADA TOTEBAG DALAM MATA PELAJARAN SENI BUDAYA DI KELAS X MIA 3 SMA NEGERI 3 BOYOLALI TAHUN AJARAN 2017/2018. Skripsi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Sebelas Maret Surakarta, Januari 2018. Tujuan penelitian ini adalah untuk mengetahui: (1) Proses pelaksanaan pembelajaran Lukis Totebag di kelas X MIA 3 SMA Negeri 3 Boyolali tahun ajaran 2017/2018. Dan (2) Bagaimana bentuk hasil karya Lukis Totebag yang dihasilkan siswa di kelas X MIA 3 SMA Negeri 3 Boyolali tahun ajaran 2017/2018. Penelitian ini menggunakan pendekatan kualitatif. Sumber data yang digunakan adalah informan yang dipilih yaitu Bapak Subandiyo S.Pd selaku guru mata pelajaran seni budaya di kelas X MIA 3 SMA Negeri 3 Boyolali, serta foto proses pembelajaran, hasil karya siswa dan dokumen arsip. Teknik yang digunakan dalam pengumpulan data adalah observasi langsung, wawancara terstruktur dan mendalam, serta dokumentasi. Uji validitas data dilakukan dengan membandingkan sumber data yang di peroleh berupa daftar hasil wawancara dengan Bapak Subandiyo S.Pd selaku guru mata pelajaran Seni Budaya dengan siswa di kelas X MIA 3 SMA Negeri 3 Boyolali, serta review informant. Analisis data yang digunakan adalah model analisis mengalir, yaitu: reduksi data, sajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa: (1) Pembelajaran Lukis Totebag diawali dengan pembuatan RPP, selanjutnya pembelajaran dilaksanakan selama tiga kali pertemuan. Strategi yang digunakan guru dalam pembelajaran ini adalah pendekatan scientific. Metode pembelajaran yang digunakan meliputi metode ceramah, tanya jawab, diskusi, dan pemberian tugas. Media pembelajaran yang digunakan berupa slide power point dan media visual berupa sampel karya dari guru. Evaluasi pembelajaran dilakukan dengan menilai aspek kognitif, afektif, dan psikomotorik. Proses pembuatan karya dilakukan dengan beberapa langkah, yaitu membuat sketsa, proses pewarnaan, dan finishing. (2) Secara umum pembuatan karya lukis totebag siswa sudah baik, teknik lukis pada pewarnaan dan finishing dalam membuat karya lukis totebag sudah baik. Karya lukis totebag yang dihasilkan oleh siswa sudah mengandung unsur-unsur seni rupa, yaitu: garis, bentuk, bidang, gelap terang, dan warna. Selain itu, karya lukis totebag yang dihasilkan oleh siswa juga sudah mengandung prinsip-prinsip seni rupa, yaitu: irama (rhytm), dominasi (dominance), keseimbangan (balance), kesatuan (unity), keserasian (harmony), dan kesebandingan (proportion). Kata Kunci: Seni Budaya, Pembelajaran Seni Rupa, Lukis Toteba

TP53 mutation predicts the poor prognosis of non-Hodgkin lymphomas: Evidence from a meta-analysis

<div><p>Non-Hodgkin lymphoma (NHL) is a group of malignant hematologic disorders with high heterogeneity. The diagnosis, clinical manifestations, classification, and prognosis of this condition differ among numerous NHL subgroups. The prognostic significance of the mutation of TP53, a tumor suppressor gene involved in cell cycle regulation, should be confirmed in NHL. In this study, our searching strategy and inclusion criteria were implemented, and the pooled hazard ratios (HRs) of the included studies were calculated directly or indirectly. A total of 1,851 patients were enrolled in 22 studies. A meta-analysis was then performed using STATA version 12.0 to confirm the correlation between the status of TP53 mutation and the survival time of patients with NHL. Statistical heterogeneity was assessed with a chi-square-based Q statistical test and Inconsistency index (<i>I</i>²) statistic. Sensitivity analysis and publication bias were also evaluated. A total of 22 studies were included in our meta-analysis. The pooled HR of the overall survival from 20 studies was 2.30 (95% CI: 1.92–2.76, p = 0.001) with heterogeneity (I² 30.2% p = 0.099). The pooled HR of the progression free survival provided in 5 articles was 2.28 (95% CI: 1.78–2.93, p = 0.001) with heterogeneity (I² 39.8% p = 0.156). No publication bias was found among the included studies, and sensitivity analysis suggested that the combined HRs were stable after any of the studies was excluded from our meta-analysis. This study identified the prognostic significance of TP53 mutation that varied in different NHL subgroups. The group with a mutated TP53 was significantly associated with poor prognosis in patients with NHL. This parameter is a valuable basis for accurate individual therapeutic regimens.</p></div

DataSheet_1_MiR-199a-3p-regulated alveolar macrophage-derived secretory autophagosomes exacerbate lipopolysaccharide-induced acute respiratory distress syndrome.pdf

PurposeAcute respiratory distress syndrome (ARDS) is a prevalent illness in intensive care units. Extracellular vesicles and particles released from activated alveolar macrophages (AMs) assist in ARDS lung injury and the inflammatory process through mechanisms that are unclear. This study investigated the role of AM-derived secretory autophagosomes (SAPs) in lung injury and microRNA (MiR)-199a-3p-regulated inflammation associated with ARDS in vitro and in a murine model.MethodsThe ARDS model in mouse was established by intratracheal LPS lipopolysaccharide (LPS) injection. The agomirs or antagomirs of MiR-199a-3p were injected into the caudal vein to figure out whether MiR-199a-3p could influence ARDS inflammation and lung injury, whereas the mimics or inhibitors of MiR-199a-3p, siRNA of Rab8a, or PAK4 inhibitor were transfected or applied to RAW264.7 cells to evaluate the mechanism of SAP release. Culture supernatants of RAW264.7 cells treated with LPS or bronchoalveolar lavage fluid from mice were collected for the isolation of SAPs.ResultsWe found that MiR-199a-3p was over-expressed in the lungs of ARDS mice. The MiR-199a-3p antagomir alleviated, whereas the MiR-199a-3p agomir exacerbated LPS-induced inflammation in mice by promoting AM-derived SAP secretion. In addition, MiR-199a-3p over-expression exacerbated LPS-induced ARDS via activating Rab8a, and Rab8a silencing significantly suppressed the promoting influence of the MiR-199a-3p mimic on SAP secretion. Furthermore, MiR-199a-3p mimic activated Rab8a by directly inhibiting PAK4 expression.ConclusionThe novel finding of this study is that MiR-199a-3p participated in the regulation of SAP secretion and the inflammatory process via targeting of PAK4/Rab8a, and is a potential therapeutic candidate for ARDS treatment.</p

Flow diagram of the relevant studies selection procedure.

<p>Flow diagram of the relevant studies selection procedure.</p

The Hazard Ratio (HR) of TP53 mutation with the Overall Survival (OS) of different subtypes.

<p>HR > 1 implied worse OS for the TP53 mutated group.</p

Characteristics of studies included in the meta-analysis.

<p>Characteristics of studies included in the meta-analysis.</p

The sensitivity analysis of the Overall Survival (OS).

<p>The sensitivity analysis of the Overall Survival (OS).</p

Synthesis of 1,2-Diketones via a Metal-Free, Visible-Light-Induced Aerobic Photooxidation of Alkynes

1,2-Diketones were synthesized by the oxidation of corresponding alkynes using air as the oxidant under metal-free conditions upon irradiation of blue light. A cheap and readily available organic dye, eosin Y, was used as the photocatalyst. For various substituents on the aryl ring, the reaction proceeded smoothly to give the dicarbonylation products in moderate to good yields. Some oxidation-sensitive groups, such as formyl and the carbon–carbon double bond, were tolerated under the developed reaction conditions

The Hazard Ratio (HR) of TP53 mutation with the Progression Free Survival (PFS).

<p>HR > 1 implied worse PFS for the TP53 mutated group.</p