Variability in the extreme helium star LSS 5121

We report a photometric and spectroscopic study of the hot extreme helium star LSS 5121. We found photometric variability, but no period was evident in its periodogram. This is consistent with the previous proposal, based on spectral line variations, that LSS 5121 is a non-radial pulsator similar to other hot extreme helium stars.Comment: 5 pages, 6 figure

Development and performance of the Fast Neutron Imaging Telescope for SNM detection

FNIT (the Fast Neutron Imaging Telescope), a detector with both imaging and energy measurement capabilities, sensitive to neutrons in the range 0.8-20 MeV, was initially conceived to study solar neutrons as a candidate design for the Inner Heliosphere Sentinel (IHS) spacecraft of NASA\u27s Solar Sentinels program and successively reconfigured to locate fission neutron sources. By accurately identifying the position of the source with imaging techniques and reconstructing the Watt spectrum of fission neutrons, FNIT can detect samples of special nuclear material (SNM), including heavily shielded and masked ones. The detection principle is based on multiple elastic neutron-proton scatterings in organic scintillators. By reconstructing n-p event locations and sequence and measuring the recoil proton energies, the direction and energy spectrum of the primary neutron flux can be determined and neutron sources identified. We describe the design of the FNIT prototype and present its energy reconstruction and imaging performance, assessed by exposing FNIT to a neutron beam and to a Pu fission neutron source

A state-level study of opioid use disorder treatment access and neonatal abstinence syndrome

Background Adult opioid use and neonatal abstinence syndrome (NAS) are growing public health problems in the United States (U.S.). Our objective was to determine how opioid use disorder treatment access impacts the relationship between adult opioid use and NAS. Methods We conducted a cross-sectional state-level ecologic study using 36 states with available Healthcare Cost and Utilization Project State Inpatient Databases in 2014. Opioid use disorder treatment access was determined by the: 1) proportion of people needing but not receiving substance use treatment, 2) density of buprenorphine-waivered physicians, and 3) proportion of individuals in outpatient treatment programs (OTPs). The incidence of NAS was defined as ICD-9 code 779.5 (drug withdrawal syndrome in newborn) from any discharge diagnosis field per 1000 live births in that state. Results Unmet need for substance use disorder treatment correlated with NAS (r = 0.54, 95% CI: 0.26–0.73). The correlation between adult illicit drug use/dependence and NAS was higher in states with a lower density of buprenorphine-waivered physicians and individuals in OTPs. Conclusions Measures of opioid use disorder treatment access dampened the correlation between illicit drug use/dependence and NAS. Future studies using community- or individual-level data may be better poised to answer the question of whether or not opioid use disorder treatment access improves NAS relative to adult opioid use

Development of the fast neutron imaging telescope

We report on the development of a next generation neutron telescope, with imaging and energy measurement capabilities, sensitive to neutrons in the 2-20 MeV energy range. The Fast Neutron Imaging Telescope (FNIT) was initially conceived to study solar neutrons as a candidate instrument for the Inner Heliosphere Sentinels (IHS) program under formulation at NASA. This detector is now being adapted to locate Special Nuclear Material (SNM) for homeland security purposes by detecting fission neutrons and reconstructing the image of their source. In either case, the detection principle is based on multiple elastic neutron-proton scatterings in organic scintillator. By reconstructing the scattering coordinates and measuring the recoil proton energy, the direction and energy of each neutron can be determined and discrete neutron sources identified. We describe the performance of the FNIT prototype, report on the current status of R&D efforts and present the results of recent laboratory measurements

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell-cell adhesion 'multicellular aggregation' for survival. Multicellular aggregation of tumor cells also significantly determines the sensitivity of tumor cells to the cytotoxic effects of chemotherapeutics. In this report, we demonstrate that expression of immunoglobulin containing and proline-rich receptor-1 (IGPR-1) is upregulated in human primary colon cancer. Our study demonstrates that IGPR-1 promotes tumor multicellular aggregation, and interfering with its adhesive function inhibits multicellular aggregation and, increases cell death. IGPR-1 supports colon carcinoma tumor xenograft growth in mouse, and inhibiting its activity by shRNA or blocking antibody inhibits tumor growth. More importantly, IGPR-1 regulates sensitivity of tumor cells to the chemotherapeutic agent, doxorubicin/adriamycin by a mechanism that involves doxorubicin-induced AKT activation and phosphorylation of IGPR-1 at Ser220. Our findings offer novel insight into IGPR-1's role in colorectal tumor growth, tumor chemosensitivity, and as a possible novel anti-cancer target.Grant support from: R01 CA175382/CA/NCI NIH HHS/United States, R21 CA191970/CA/NCI NIH HHS/United States, and R21 CA193958/CA/NCI NIH HHS/United State

Fast Monte Carlo simulations and singularities in the probability distributions of non-equilibrium systems

A numerical technique is introduced that reduces exponentially the time required for Monte Carlo simulations of non-equilibrium systems. Results for the quasi-stationary probability distribution in two model systems are compared with the asymptotically exact theory in the limit of extremely small noise intensity. Singularities of the non-equilibrium distributions are revealed by the simulations.Comment: 4 pages, 4 figure

Tidal resource and interactions between multiple channels in the Goto Islands, Japan

The Goto Islands in Nagasaki Prefecture, Japan, contain three parallel channels that are suitable for tidal energy development and are the planned location for a tidal energy test centre. Energy extraction is added to a 3D numerical hydrodynamic model of the region, using a sub-grid momentum sink approach, to predict the effects of tidal development. The available resource with first-generation turbines is estimated at 50-107MW peak output. Spreading turbine thrust across the whole cross-section to prevent bypass flow results in a 64% increase in peak power in one channel, highlighting the importance of 3D over 2D modelling. The energy available for extraction in each strait appears to be independent of the level of extraction in other straits. This contrasts with theoretical and numerical studies of other multi-channel systems. The weak interactions found in this study can be traced to the hydraulic effects of energy extraction not extending to neighbouring channels due to their geometry