Data on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans

© 2016 The Authors. Synthetic cannabinoids JWH-018, JWH-073 and AM2201 were metabolised by the fungus Cunninghamella elegans. In this article, data on individual metabolites of their retention times, mass accuracies, major product ions and structures indicated by product ions are presented. The data in this article is related to "Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans" [1]

Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans

© 2015 Elsevier Ireland Ltd. Being marketed as "legal" smoking blends or mixtures, synthetic cannabinoids are abused widely owing to its cannabis-like effect. Due to the rapid introduction of new generation analogues of synthetic cannabinoids to escape from legislative/judicial control, the investigation of the metabolic pathways of these substances is of particular importance for drug control, abstinence and forensic toxicology purposes. In this study, the in vitro metabolism of JWH-018, JWH-073 and AM2201 by the fungus Cunninghamella elagans has been investigated with the purpose of validating its potential as a complementary model for investigating synthetic cannabinoid metabolism. JWH-018, JWH-073 and AM2201 were incubated for 72 h with C. elegans. Detection of metabolites was based on liquid chromatography-tandem mass spectrometry and high resolution mass spectrometry analysis. C. elegans was found capable of producing the majority of the phase I metabolites observed in earlier in vitro and in vivo mammalian studies as a result of monohydroxylation, dihydroxylation, carboxylation, dehydrogenation, ketone formation, dihydrodiol formation, dihydrodiol formation with N-dealkylation and combinations thereof. C. elegans can thus be a useful and economic model for studying synthetic cannabinoid metabolism

Fatigue properties of Ti6Al4V cellular specimens fabricated via SLM: CAD vs real geometry

Abstract Fully dense titanium alloy implants have long been used for the replacement and stabilization of damaged bone tissue. Nevertheless, they can cause stress shielding which brings to a loss of bone mass. Additive manufacturing (AM) allows obtaining highly porous cellular structures with a wide range of cell morphologies to tune the mechanical properties to match that of the patient's bone. In this work, the fully reversed fatigue strength of cellular specimens produced by Selective Laser Melting (SLM) of Ti-6Al-4V alloy was measured. Their structures are determined by cubic cells packed in six different ways and their elastic modulus is roughly 3GPa to match that of trabecular bone. Part of the specimens was left as sintered and part treated by Hot Isostatic Pressing (HIP). The fatigue resistance of such AM parts can be affected by surface morphology, geometrical accuracy as well as internal defects. Micro X-ray computed tomography (CT) was used in this work to compare the geometry of the produced specimens with the CAD model and to carry out residual stress measurements using the Plasma FIB-SEM-DIC micro-hole drilling method

Constraining the degree of the dominant mode in QQ Vir

We present early results of the application of a method which uses multicolor photometry and spectroscopy for \ell discrimination. This method has been successfully applied to the pulsating hot subdwarf Balloon 090100001. Here we apply the method to QQ Vir (PG1325+101). This star was observed spectroscopically and photometrically in 2008. Details on spectroscopy can be found in Telting et al. (2010) while photometry and preliminary results on \ell discrimination are provided here. The main aim of this work was to compare the value of the \ell parameter derived for the main mode in QQ Vir to previously published values derived by using different methods.Comment: Proceedings of The Fourth Meeting on Hot Subdwarf Stars and Related Objects held in China, 20-24 July 2009. Accepted for publication in Astrophysics and Space Scienc

A holomorphic representation of the Jacobi algebra

A representation of the Jacobi algebra $\mathfrak{h}_1\rtimes \mathfrak{su}(1,1)$ by first order differential operators with polynomial coefficients on the manifold $\mathbb{C}\times \mathcal{D}_1$ is presented. The Hilbert space of holomorphic functions on which the holomorphic first order differential operators with polynomials coefficients act is constructed.Comment: 34 pages, corrected typos in accord with the printed version and the Errata in Rev. Math. Phys. Vol. 24, No. 10 (2012) 1292001 (2 pages) DOI: 10.1142/S0129055X12920018, references update

Precursor flares in OJ 287

We have studied three most recent precursor flares in the light curve of the blazar OJ 287 while invoking the presence of a precessing binary black hole in the system to explain the nature of these flares. Precursor flare timings from the historical light curves are compared with theoretical predictions from our model that incorporate effects of an accretion disk and post-Newtonian description for the binary black hole orbit. We find that the precursor flares coincide with the secondary black hole descending towards the accretion disk of the primary black hole from the observed side, with a mean z-component of approximately z_c = 4000 AU. We use this model of precursor flares to predict that precursor flare of similar nature should happen around 2020.96 before the next major outburst in 2022.Comment: to appear in the Astrophysical Journa

Asteroids in the Inner Solar System I - Existence

Ensembles of in-plane and inclined orbits in the vicinity of the Lagrange points of the terrestrial planets are integrated for up to 100 million years. The integrations incorporate the gravitational effects of Sun and the eight planets (Pluto is neglected). Mercury is the least likely planet, as it is unable to retain tadpole orbits over 100 million year timescales. Both Venus and the Earth are much more promising, as they possess rich families of stable tadpole and horseshoe orbits. Our survey of Trojans in the orbital plane of Venus is undertaken for 25 million years. Some 40% of the survivors are on tadpole orbits. For the Earth, the integrations are pursued for 50 million years. The stable zones in the orbital plane are larger for the Earth than for Venus, but fewer of the survivors are tadpoles. Both Venus and the Earth also have regions in which inclined test particles can endure near the Lagrange points. For Venus, only test particles close to the orbital plane are stable. For the Earth, there are two bands of stability, one at low inclinations (i < 16 degrees) and one at moderate inclinations (between 24 degrees and 34 degrees). The inclined test particles that evade close encounters are primarily moving on tadpole orbits. Our survey of in-plane test particles near the Martian Lagrange points shows no survivors after 60 million years. Low inclination test particles do not persist, as their inclinations are quickly increased until the effects of a secular resonance with Jupiter cause de-stabilisation. Numerical integrations of inclined test particles for timespans of 25 million years show stable zones for inclinations between 14 and 40 degrees.Comment: 20 pages, 21 figures, Monthly Notices (in press

No maintenance -- no energy efficiency

Field investigations illustrate that it is not realistic to expect new high-tech equipment to function for a full life expectancy at high efficiency without significant operations and maintenance (O&M). A simple walk through inspection of most buildings reveals extensive equipment that is being operated on manual override, is incorrectly adjusted and operating inefficiently, or is simply inoperative. This point is illustrated with two examples at Robins Air Force Base, Georgia. The first describes development of a comprehensive, base-wide, steam trap maintenance program. The second describes a measured evaluation from a typical office building. The objective of both examples was to assess the importance of proper O&M. The proposed ``O&M First`` philosophy will result in more efficient building HVAC operation, provide improved services to the building occupants, and reduce energy consumption and unscheduled equipment repair/replacement. Implementation of a comprehensive O&M program will result in a 15--25% energy savings. The O&M foundation that is established will allow other energy conservation activities such is demand side management or energy management and control systems, to achieve and maintain their expected energy savings