Ordovician volcanic and hypabyssal rocks in the central and southern Miramichi Highlands: their tectonic setting and relationship to contemporary volcanic rocks in northern New Brunswick

New analyses of mafic igneous rocks from the central Miramichi Highlands have led us to modify the interpretation of its tectonic setting. New samples have been obtained from the Bam ford Brook and Trousers Lake areas of New Brunswick, and the Danforth area in Maine. All subalkalic mafic rocks, including the Trousers Lake striped amphibolites, are associated with a thick sequence of metasedimentary rocks and all are continental tholeiites, analogous to tholeiitic suites in the Tetagouche Group of the northern Miramichi Highlands. The presence of alkalic basalt and comendite in this area supports this correlation. In the southern Miramichi Highlands of Maine, silicic and intermediate volcanic rocks form part of the Woodstock-Meductic arc-related volcanic suite. RÉSUMÉ De nouvelles analyses de roches ignées mafiques provenant du centre des hautes-terres de la Miramichi nous ont conduit à modifier l’interprétation de leur environnement tectonique. De nouveaux échantillons ont été recueillis dans les régions du ruisseau Bamford et du lac Trousers au Nouveau-Brunswick, et dans la région de Danforth au Maine. Toutes les roches mafiques subalcalines, incluant les amphibolites rubannées du lac Trousers, sont associées avec une séquence épaisse de roches métasédimentaires et sont toutes des tholéiites continentales, similaires aux suites tholéiitiques appartenant au Groupe de Tétagouche du nord des hautes-terres de la Miramichi. La présence de basaltes alcalins et de comendites dans cette région appuie cette corrélation. Dans le sud des hautes-terres de la Miramichi au Maine, les volcanites siliceuses et inlermddiaires constituent une partie de la suite volcanique d'arc de Woodstock-Meductic. [Traduit par le journal

English individualism refuted - and reasserted: the land market of Earls Colne (Essex), 1550-1750

This is the author's post-print version of an article whose final and definitive form has been published in The Economic History Review. © 2003 Blackwell Publishing Ltd. The definitive version is available at: http://www3.interscience.wiley.com/journal/118509292/homeEarls Colne first came to the notice of historians through Macfarlane's study of its seventeenth-century vicar, Ralph Josselin, and then Macfarlane's use of evidence from the village in his The Origins of English Individualism (1978). This article presents preliminary results drawn from a computer-based reconstruction of the copyhold land market, 1546-1750, to contest Macfarlane's reading of the family-land bond in the manor. The familial possession of land over long periods is shown to be normal, and consistent with an active land market predominantly in smaller parcels. Little consolidation took place in the manor although some growth in holding size was achieved through subtenancy. Finally, the article asks whether the experience of copyholders is typical of the general.University of Central Lancashir

Inkjet printed GPS antenna on a 3D printed substrate using low-cost machines

Additive manufacturing (AM), also known as 3D printing, is a process of fabricating a 3D digital design by printing layer after layer. 3D printing has advanced very rapidly in recent years and has become an alternative to traditional manufacture methods for customized objects. Originally intended for the prototyping of mechanical objects, this technique has expanded into different areas such as biomedical [1] and electronics [2]. Within electronics, antennas and microwave engineering can greatly benefit from this technology. Researchers have already demonstrated the potential applicability of 3D printing in this field. Light weight waveguides have been fabricated by copper plating plastics forms [3]. Substrates for antenna applications have been modified and new properties have been found with the assistance of additive manufacturing [4]. Novel frequency selective structures (FSS) have been developed by fully [5] and partially [6] metalizing 3D printed elements. Non-uniform electromagnetic band gap structures have been fabricated on printed substrates [7]. Antennas have been placed onto wearables and tested on 3D printed phantoms [8]–[9]. Fig. 1

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity

Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.

BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. OBJECTIVES: The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. DESIGN: Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). SETTING: Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. PARTICIPANTS: Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. INTERVENTIONS: No interventions were performed. MAIN OUTCOME MEASURES: (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. RESULTS: A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). LIMITATIONS: Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. CONCLUSIONS: We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. FUTURE WORK: A large case-control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information

Validity of smartphone heart rate variability pre- and post-resistance exercise

The aim was to examine the validity of heart rate variability (HRV) measurements from photoplethysmography (PPG) via a smartphone application pre- and post-resistance exercise (RE) and to examine the intraday and interday reliability of the smartphone PPG method. Thirty-one adults underwent two simultaneous ultrashort-term electrocardiograph (ECG) and PPG measurements followed by 1-repetition maximum testing for back squats, bench presses, and bent-over rows. The participants then performed RE, where simultaneous ultrashort-term ECG and PPG measurements were taken: two pre- and one post-exercise. The natural logarithm of the root mean square of successive normal-to-normal (R-R) differences (LnRMSSD) values were compared with paired-sampl

Effect of nucleon exchange on projectile multifragmentation in the reactions of 28Si + 112Sn and 124Sn at 30 and 50 MeV/nucleon

Multifragmentation of quasiprojectiles was studied in reactions of 28Si beam with 112Sn and 124Sn targets at projectile energies 30 and 50 MeV/nucleon. The quasiprojectile observables were reconstructed using isotopically identified charged particles with Z_f <= 5 detected at forward angles. The nucleon exchange between projectile and target was investigated using isospin and excitation energy of reconstructed quasiprojectile. For events with total reconstructed charge equal to the charge of the beam (Z_tot = 14) the influence of beam energy and target isospin on neutron transfer was studied in detail. Simulations employing subsequently model of deep inelastic transfer, statistical model of multifragmentation and software replica of FAUST detector array were carried out. A concept of deep inelastic transfer provides good description of production of highly excited quasiprojectiles. The isospin and excitation energy of quasiprojectile were described with good overall agreement. The fragment multiplicity, charge and isospin were reproduced satisfactorily. The range of contributing impact parameters was determined using backtracing procedure.Comment: 11 pages, 8 Postscript figures, LaTeX, to appear in Phys. Rev. C ( Dec 2000

Tracing the Evolution of Temperature in Near Fermi Energy Heavy Ion Collisions

The kinetic energy variation of emitted light clusters has been employed as a clock to explore the time evolution of the temperature for thermalizing composite systems produced in the reactions of 26A, 35A and 47A MeV $^{64}$Zn with $^{58}$Ni, $^{92}$Mo and $^{197}$Au. For each system investigated, the double isotope ratio temperature curve exhibits a high maximum apparent temperature, in the range of 10-25 MeV, at high ejectile velocity. These maximum values increase with increasing projectile energy and decrease with increasing target mass. The time at which the maximum in the temperature curve is reached ranges from 80 to 130 fm/c after contact. For each different target, the subsequent cooling curves for all three projectile energies are quite similar. Temperatures comparable to those of limiting temperature systematics are reached 30 to 40 fm/c after the times corresponding to the maxima, at a time when AMD-V transport model calculations predict entry into the final evaporative or fragmentation stage of de-excitation of the hot composite systems. Evidence for the establishment of thermal and chemical equilibrium is discussed.Comment: 9 pages, 5 figure

Acute Blood Flow Responses to Varying Blood Flow Restriction Pressures in the Lower Limbs

International Journal of Exercise Science 16(2): 118-128, 2023. The purpose of this study was to investigate lower limb blood flow responses under varying blood flow restriction (BFR) pressures based on individualized limb occlusion pressures (LOP) using a commonly used occlusion device. Twenty-nine participants (65.5% female, 23.8 ± 4.7 years) volunteered for this study. An 11.5cm tourniquet was placed around participants’ right proximal thigh, followed by an automated LOP measurement (207.1 ± 29.4mmHg). Doppler ultrasound was used to assess posterior tibial artery blood flow at rest, followed by 10% increments of LOP (10-90% LOP) in a randomized order. All data were collected during a single 90-minute laboratory visit. Friedman’s and one-way repeated-measures ANOVAs were used to examine potential differences in vessel diameter, volumetric blood flow (VolFlow), and reduction in VolFlow relative to rest (%Rel) between relative pressures. No differences in vessel diameter were observed between rest and all relative pressures (all p \u3c .05). Significant reductions from rest in VolFlow and %Rel were first observed at 50% LOP and 40% LOP, respectively. VolFlow at 80% LOP, a commonly used occlusion pressure in the legs, was not significantly different from 60% (p = .88), 70% (p = .20), or 90% (p = 1.00) LOP. Findings indicate a minimal threshold pressure of 50%LOP may be required to elicit a significant decrease in arterial blood flow at rest when utilizing the 11.5cm Delfi PTSII tourniquet system