Analysis of thrust augmentation of turbojet engines by water injection at compressor inlet including charts for calculating compression processes with water injection

A psychrometric chart having total pressure (sum of partial pressures of air and water vapor) as a variable, a Mollier diagram for air saturated with water vapor, and charts showing the thermodynamic properties of various air-water vapor and exhaust gas-water vapor mixtures are presented as aids in calculating the thrust augmentation of a turbojet engine resulting from the injection of water at the compressor inlet. Curves are presented that show the theoretical performance of the augmentation method for various amounts of water injected and the effects of varying flight Mach number, altitude, ambient-air temperature, ambient relative humidity, compressor pressure ratio, and inlet-diffuser efficiency. Numerical examples, illustrating the use of the psychrometric chart and the Mollier diagram in calculating both compressor-inlet and compressor-outlet conditions when water is injected at the compressor inlet, are presented

Theoretical Comparison of Several Methods of Thrust Augmentation for Turbojet Engines

A theoretical investigation of tail-pipe burning, water injection at the compressor inlet, combination tail-pipe burning plus water injection, bleedoff, and rocket-assist methods thrust augmentation for turbojet engines was made for an engine representative of those in current use. The effect of augmented liquid ratio on augmented thrust ratio and the effects of altitude and flight Mach number on the performance of various methods were determined. The additional take-off weight involved by the use of the different thrust augmentation methods, as well as the effect of the various thrust augmentation methods on the range of a representative aircraft was also investigated

Analysis of the turbojet engine for propulsion of supersonic fighter airplanes / David S. Gabriel, Richard P. Krebs, E.Clinton Wilcox, Stanley L.Koutz

An analytical investigation was made of two supersonic interceptor type airplanes to determine the most desirable turbojet engine characteristics for this application The airplanes were designed differently primarily because of the amount of subsonic flight incorporated in the flight plan--one flight having none and the other, a cruise radius of 400 nautical miles. Several power plant design variables were varied independently to determine the effect of changes in each parameter on airplane performance. These parameters included compressor pressure ratio, compressor efficiency, turbine-inlet temperature, afterburner temperature, engine specific weight, and air-handling capacity. The effects of using a convergent-divergent exhaust nozzle and of changing the design flight Mach number were also investigated

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR, and SPINK1 variants were associated with pancreatitis risk. We now report two significant genome-wide associations identified and replicated at PRSS1-PRSS2 (1×10-12) and x-linked CLDN2 (p < 1×10-21) through a two-stage genome-wide study (Stage 1, 676 cases and 4507 controls; Stage 2, 910 cases and 4170 controls). The PRSS1 variant affects susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous male) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men – male hemizygous frequency is 0.26, female homozygote is 0.07

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

NACA Technical Notes

Report presenting an investigation of the thrust augmentation of a turbojet engine resulting from the evaporation of water prior to mechanical compression over a range of flight Mach numbers, altitudes, ambient temperatures, and ambient relative humidities. The amount of thrust augmentation possible from compressor-inlet-air saturation increased with an increase in flight Mach number and decreased as the altitude was increased. Results regarding the psychrometric chart, generalized performance analysis, and augmentation calculations are provided

NACA Research Memorandums

"A theoretical investigation has been made of various methods of thrust augmentation for turbojet engines. The method investigated were tail-pipe burning, water injection at the compressor inlet, a combination of tail-pipe burning and water injection, bleedoff in conjunction with water injection at the compressor inlet, and rocket assist. The effect of ratio of augmented-to-normal total liquid consumption, flight conditions, and design compressor pressure ratio on the augmentation produced by each method were determined" (p. 1)

NACA Technical Reports

"A theoretical investigation of tail-pipe burning, water injection at the compressor inlet, combination tail-pipe burning plus water injection, bleedoff, and rocket-assist methods thrust augmentation for turbojet engines was made for an engine representative of those in current use. The effect of augmented liquid ratio on augmented thrust ratio and the effects of altitude and flight Mach number on the performance of various methods were determined. The additional take-off weight involved by the use of the different thrust augmentation methods, as well as the effect of the various thrust augmentation methods on the range of a representative aircraft was also investigated" (p. 727)