The Human Phenotype Ontology in 2024: phenotypes around the world.

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

The Human Phenotype Ontology in 2024: phenotypes around the world

\ua9 The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research. The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

Video oberservation of waves and shoreline change on the microtidal James Town Beach in Ghana

The morphology of sandy beaches is highly dynamic. They are influenced by the geology of the coastal area and external hydrodynamic forcing. On long timescales (years to decades), it is more efficient and convenient to monitor beach evolution through remote sensing technics rather than through direct field measurements. Erosion is a major problem along the coastline of Ghana with over 25 erosion hotspots, including James town. Here, tides, ECMWF EraInterim re-analysis wave data and images covering the beach area have been obtained for the 2013-2014 period. This paper presents preliminary results of the first efforts in processing video-derived observations of waves and shoreline change in Ghana. The pilot application shows a strong potential of the video system in providing fair quality wave data for beach management purposes where video wave characteristics are in good agreement with EraInterim global reanalysis (daily RMSE = 0.8 m and 0.7 m for H-b and T-p, respectively). Shorelines extracted from video suggest large monthly variability driven by wave seasonality while shoreline change shows a subsequent erosion/accretion cycle

Progress in Coastal Processes Research in Ghana

In this work, we discuss an international research program focused on coastal processes in Ghana, presently in the middle stages of development. The goal of the ONR-sponsored program is for the University of Ghana to become a regional leader that produces top-flight and internationally relevant research in coastal processes. This is accomplished by creating partnerships with a variety of US and European institutions where education and capacity-building exercises for working in coastal environments are implemented. Part of the program is focused on shallow water processes with international participants providing expertise on in-depth theoretical knowledge, numerical model development and implementation, and field observation techniques, processing, and data assimilation methods. Program activities include a series of workshops conducted in 2008 and 2009 at the University of Ghana, and the development of field capabilities to observe coastal change with in situ and remote sensing instrumentation. The coastal and marine environment of Ghana contributes significantly to the economic development and security of the country. Ghana has demarcated a 200 nautical mile EEZ within the framework of UNCLOS. This has brought vast living and non-living resources under Ghanaian jurisdiction. Furthermore, shipping traffic continues to rise and associated problems with ballast water and potential oil spill raises concern for ecosystem health. The ability to monitor the environment will contribute immensely to the management of the marine ecosystem. The coastline of Ghana measures approximately 550 km and is generally a low-lying area not exceeding 30 m above sea level. The geomorphology of the coastline varies, ranging from coastal lagoons with barrier beaches to rocky cliffs fronted by narrow beaches to a large wave-dominated deltaic system (the Volta Delta). The coastal area is also bordered by a narrow continental shelf extending outwards between 30 and 90 km. Presently, there are high rates of retreat or erosion along many sections of the coastline. Shoreline recession is driven by the interplay of several factors, as wave and tidal forcing interacts with local sediment budgets (including anthropogenic disruption of sediment supply); in many cases, these processes remain poorly understood. In some areas, erosion is undermining or threatening major coastal roadways and other infrastructure. Limited resources to mitigate this threat as well as geographical constraints make this a serious problem for local communities and commerce. Understanding the past behavior of the system and the processes that drive coastal change in Ghana are critical to forecasting changes along the coastline. The research program is specifically providing assistance in the development of predictive numerical models and observational networks to examine these and other coastal-related problems

Design of a Secure Wireless Home Automation System with an Open Home Automation Bus (OpenHAB 2) Framework

There is rapid interest growing in the use of smart, connected devices. The developing world market for smart technology is evolving to adopt and adapt to the interconnected world of devices leading to the Internet of Things (IoT) everywhere. This research paper presents the design, development, and deployment of a prototype for the secure wireless home automation system with OpenHAB 2. We employed the use of two (2) high-performance microcontrollers, namely, the Arduino Mega 2560, interfaced with a 16-channel relay, and Raspberry Pi Model B, running the OpenHAB software. The Raspberry Pi functioned as the server to develop a prototype of an automated smart home that is remotely controllable from both a web application and an Android mobile app. In designing a wireless controlled switch for home appliances, two security procedures were implemented, namely, the token-based JSON Web Token (JWT) interface and Advanced Encryption Standard (AES) procedures for authentication and data encryption. Our system delivered a home automation system that leverages on the power of the latest version of OpenHAB to maximize productivity and overall home security while making it adaptable to the management of individual devices. When tested, both the developed hardware and software modules performed extremely well to meet the goal of a secured home automation system. Industry-standard penetration testing tools and frameworks, including Aircrack-ng, were utilized; wireless network audit began with a full sweep of the wireless frequencies with excellent results. It also ensures the efficient use of energy in the home as devices are intelligently controlled from both mobile and web applications. The results of the design and implementation of the additional layer for the security of the OpenHAB framework provide various theoretical and practical implications for home automation

Comparative Assessment of Knowledge, Attitudes, and Practice of Breast Self-Examination among Female Secondary and Tertiary School Students in Ghana

Background. Breast cancer remains a serious public health problem globally. It is particularly increasing among adolescents and premenopausal women. Breast self-examination (BSE) is the most effective and feasible means of detecting breast cancer early in developing countries. This study aimed at evaluating and comparing knowledge of BSE among secondary and tertiary school students and at revealing their attitudes and practices about BSE. Method. This cross-sectional study was conducted among 1036 female secondary and tertiary school students of Kwame Nkrumah University of Science and Technology and Technology Senior High School. Data was obtained using a pretested questionnaire to access sociodemography, knowledge, attitudes, and practice of BSE among the students. Result. Most students were within the age of 15–24 years; 90.9% were aware of BSE. A high level of knowledge on BSE was found in 54.5% of the students. Knowledge was significantly higher in tertiary than secondary school students (p=0.002). 24.1% of the students thought BSE could be performed anytime; however only 8.1% of the students performed BSE monthly as recommended, whilst 41.8% had never practiced. Of these, more secondary students had never practiced BSE as compared to the tertiary students. 22.3% indicated they would wait for a change in a detected breast lump before seeking medical attention. 96.3% of the participants agree BSE is a good practice which must be encouraged. Conclusion. Teaching of BSE should be intensified beginning at the high school level, emphasizing practice and its benefits for early detection of breast cancer

The Human Phenotype Ontology in 2024: phenotypes around the world

Funder: French Ministry of HealthFunder: Angela Wright Bennett Foundation; DOI: https://doi.org/10.13039/501100020544Funder: McCusker Charitable Foundation; DOI: https://doi.org/10.13039/100014834Funder: Channel 7 Telethon TrustsFunder: the Stan Perron Charitable Foundation and Mineral ResourcesFunder: Prechter Bipolar Research ProgramThe Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

The Human Phenotype Ontology in 2024: phenotypes around the world

Funder: French Ministry of HealthFunder: Angela Wright Bennett Foundation; DOI: https://doi.org/10.13039/501100020544Funder: McCusker Charitable Foundation; DOI: https://doi.org/10.13039/100014834Funder: Channel 7 Telethon TrustsFunder: the Stan Perron Charitable Foundation and Mineral ResourcesFunder: Prechter Bipolar Research ProgramThe Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs