Intelligent Playful Environments for Animals

© Owner/Author 2015. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in Interacción '15 Proceedings of the XVI International Conference on Human Computer Interaction, http://dx.doi.org/10.1145/2829875.2829879We are evolving towards an interconnected and ubiquitous world, where digital devices and interfaces progressively adapt themselves to fit our needs and ease our daily activities. Although we coexist with plenty of animal species, such as our pets, we are approaching the evolution of technology in a strictly human-centric manner. A new field in Computer Science, called Animal-Computer Interaction (ACI), aims at filling this technological gap by developing systems and interfaces specifically designed for animals. Supporting animals' natural behavior and habits with suitable technology could improve both humans and animals' wellbeing. As a consequence, this doctoral research aims to explore, design and develop animal-centered intelligent systems that focus on enhancing one of the most natural animal behaviors: play. Therefore, the main goal of this research is to expand ACI with the ability of automatically manage and adapt animals play activity in order to improve their wellbeing.Work supported by MINECO (TIN2010-20488 and TIN2014-60077-R), UPV (UPV-FE-2014-24), MECD (FPU13/03831) and GVA (APOSTD/2013/013).Pons Tomás, P.; Jaén Martínez, FJ.; Catalá Bolós, A. (2015). Intelligent Playful Environments for Animals. ACM. https://doi.org/10.1145/2829875.2829879SHu, F., Silver, D., and Trude, A. LonelyDog@Home. 2007 IEEE/WIC/ACM International Conferences on Web Intelligence and Intelligent Agent Technology - Workshops, IEEE (2007), 333--337.Huizinga, J.Homo ludens. Wolters-Noordhoff, Groningen, The Nederlands, 1985.Mancini, C. Animal-computer interaction: a manifesto. Magazine interactions 18, 4 (2011), 69--73.Mancini, C. Animal-computer interaction (ACI): changing perspective on HCI, participation and sustainability. CHI '13 Extended Abstracts on Human Factors in Computing Systems, ACM Press (2013), 2227--2236.Matsuzawa, T. The Ai project: historical and ecological contexts. Animal cognition 6, 4 (2003), 199--211.Pons, P., Jaen, J., and Catala, A. Animal Ludens: Building Intelligent Playful Environments for Animals. 11th Conference on Advances in Computer Entertainment - Workshop on Animal Human Computer Interaction, (2014).Pons, P., Jaen, J., and Catala, A. Envisioning Future Playful Interactive Environments for Animals. In A. Nijholt, ed., More Playful User Interfaces. Springer, 2015.Robinson, C., Mancini, C., van der Linden, J., Guest, C., and Harris, R. Empowering assistance dogs: an alarm interface for canine use. Intelligent Systems for Animal Welfare, (2014).Rumbaugh, D.M., Gill, T. V., Brown, J. V., et al. A computer-controlled language training system for investigating the language skills of young apes. Behavior Research Methods & Instrumentation 5, 5 (1973), 385--392.Westerlaken, M. and Gualeni, S. Felino: The Philosophical Practice of Making an Interspecies Videogame. The Philosophy of Computer Games Conference, (2014), 1--12.Wingrave, C.A., Rose, J., Langston, T., and LaViola, J.J.J. Early explorations of CAT: canine amusement and training. CHI '10 Extended Abstracts on Human Factors in Computing Systems, (2010), 2661--2669.SpeakDolphin. http://www.speakdolphin.com

Efficient Inhibition of Collagen-Induced Platelet Activation and Adhesion by LAIR-2, a Soluble Ig-Like Receptor Family Member

LAIR-1 (Leukocyte Associated Ig-like Receptor -1) is a collagen receptor that functions as an inhibitory receptor on immune cells. It has a soluble family member, LAIR-2, that also binds collagen and can interfere with LAIR-1/collagen interactions. Collagen is a main initiator for platelet adhesion and aggregation. Here, we explored the potential of soluble LAIR proteins to inhibit thrombus formation in vitro. LAIR-2/Fc but not LAIR-1/Fc inhibited collagen-induced platelet aggregation. In addition, LAIR-2/Fc also interfered with platelet adhesion to collagen at low shear rate (300 s−1; IC50 = 18 µg/ml) and high shear rate (1500 s−1; IC50 = 30 µg/ml). Additional experiments revealed that LAIR-2/Fc leaves interactions between collagen and α2β1 unaffected, but efficiently prevents binding of collagen to Glycoprotein VI and von Willebrand factor. Thus, LAIR-2/Fc has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis

Mogelijkheden voor het gebruik van zouthoudend water voor druppelbevloeiing van jonge vruchtbomen

Onderzoeksverslag, naar aanleiding waarvan globaal enige konklusies en richtlijnen worden gegeve

Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands

Background It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA. Objective We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors. Methods Likely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL). Results Of the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range <1.00*10−250–1.29*10−7). Living in a small city/large village or suburb during childhood was associated with a higher risk of LikelyFA than living on a farm (p-value = 7.81*10−4 and p = 4.84*10−4, respectively). Subjects classified as Indeterminate more often reported depression and burn-out compared to those without FA (p-value = 1.46*10−4 and p = 8.39*10−13, respectively). No association was found with ethnicity, (duration of) breastfeeding, birth mode and reported eating disorder. Mental and physical component scores measuring H-RQOL were lower in both those classified as LikelyFA and Indeterminate compared to those without FA. Conclusion The prevalence of s-rFA among adults is considerable and one-third reports characteristics consistent with LikelyFA. Living on a farm decreased the risk of LikelyFA. The association of poorer H-RQOL as well as depression and burn-out with questionable self-perceived FA is striking and a priority for future study

Agricultural Microcredit and Household Vulnerability in Rural Malawi

textabstractSixteen girls with Turner syndrome (TS) were treated for 4 years with biosynthetic growth hormone (GH). The dosage was 4IU/m2 body surface s.c. per day over the first 3 years. In the 4th year the dosage was increased to 61 U/m2 per day in the 6 girls with a poor height increment and in 1 girl oxandrolone was added. Ethinyl oestradiol was added after the age of 13. Mean (SD) growth velocities were 3.4 (0.9), 7.2 (1.7), 5.3 (1.3), 4.3 (2.0) and 3.6 (1.5) cm/year before and in the 1st, 2nd, 3rd and 4th year of treatment. Skeletal maturation advanced faster than usual in Turner patients especially in the youger children. Although the mean height prediction increased by 5.6 cm and 11 of the 16 girls have now exceeded their predicted height, the height of the 4 girls who stopped GH treatment exceeded the predicted adult height by only 0 to 3.4 cm

Prognosis in fertilisation rate and outcome in IVF cycles in patients with and without endometriosis: a population-based comparative cohort study with controls

Background: Subfertility occurs in 30-40% of endometriosis patients. Regarding the fertilisation rate with in vitro fertilisation (IVF) and endometriosis, conflicting data has been published. This study aimed to compare endometriosis patients to non-endometriosis cycles assessing fertilisation rates in IVF.Methods: A population-based cohort study was conducted at the Leiden University Medical Center. IVF cycles of endometriosis patients and controls (unexplained infertility and tubal pathology) were analysed. The main outcome measurement was fertilisation rate.Results: 503 IVF cycles in total, 191 in the endometriosis group and 312 in the control. The mean fertilisation rate after IVF did not differ between both groups, 64.1%+/- 25.5 versus 63.9%+/- 24.8 (p=0.95) respectively, independent of age and r-ASRM classification. The median number of retrieved oocytes was lower in the endometriosis group (7.0 versus 8.0 respectively, p=0.19) and showed a significant difference when corrected for age (p=0.02). When divided into age groups, the statistical effect was only seen in the group of <= 35 years (p=0.04). In the age group <= 35, the endometriosis group also showed significantly more surgery on the internal reproductive organs compared to the control group (p<0.001). All other outcomes did not show significant differences.Conclusion: Similar fertilisation rates were found in endometriosis IVF cycles compared to controls. The oocyte retrieval was lower in the endometriosis group, however this effect was only significant in the age group <= 35 years. All other secondary outcomes did not show significant differences. In general, endometriosis patients with an IVF indication can be counselled positively regarding the chances of becoming pregnant, and do not need a different IVF approach.Gynecolog

Immunological parameters in girls with Turner syndrome

Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common. Besides the typical features of Turner syndrome (short stature, failure to enter puberty spontaneously and infertility due to ovarian insufficiency) ear problems are common (recurrent otitis media and progressive sensorineural hearing disorder). Levels of IgG, IgA, IgM, IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis media. No major immunological deficiency was found that could explain the increased incidence of otitis media in the young Turner girls