A preliminary study in Wistar rats with enniatin : A contaminated feed

A 28-day repeated dose preliminary assay, using enniatin A naturally contaminated feed through microbial fermentation by a Fusarium tricinctum strain, was carried out employing two months-old female Wistar rats as in vivo experimental model. In order to simulate a physiological test of a toxic compound naturally produced by fungi, five treated animals were fed during twenty-eight days with fermented feed. As control group, five rats were fed with standard feed. At the 28th day, blood samples were collected for biochemical analysis and the gastrointestinal tract, liver and kidneys were removed from each rat for enniatin A detection and quantitation. Digesta were collected from stomach, duodenum, jejunum, ileum and colon. Enniatin A present in organs and in biological fluids was analyzed by liquid chromatography-diode array detector (LC-DAD) and confirmed by LC-mass spectrometry linear ion trap (MS-LIT); also several serum biochemical parameters and a histological analysis of the duodenal tract were performed. No adverse effects were found in any treated rat at the enniatin A concentration (20.91 mg/kg bw/day) tested during the 28-day experiment. Enniatin A quantitation in biological fluids ranged from 1.50 to 9.00 mg/kg, whereas in the gastrointestinal organs the enniatin A concentration ranged from 2.50 to 23.00 mg/kg. The high enniatin A concentration found in jejunum liquid and tissue points to them as an absorption area. Finally, two enniatin A degradation products were identified in duodenum, jejunum and colon content, probably produced by gut microflora

Stopping Power Measurements of 0.5-10.5 MeV 7Li Ions in Polyimide, Vyns, Formvar and Polysulfone.

Accurate stopping powers for 7-Li ions in four (co) polymers were measured using the transmission technique in the energy range of 0.5 - 10.5 Mev. The estimated uncertainty in the stopping power values is ~2.5%. A comparison of the experimental data is made with various parametrizations of the stopping power found in the literature. deviations of the parametrizations from our experimental data range from 5 to 20%.JRC.D-Institute for Reference Materials and Measurements (Geel

Comparison of Dynamic Simulations with RBS Measurements of Low Energy Ion Implantation of Sb into Si02/Si Substrates.

Abstract not availableJRC.D-Institute for Reference Materials and Measurements (Geel

The preparation and homogeneity study of synthetic multi-element standards (SMELS) for QC/QA of k(0)-NAA

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