Luminous K-band Selected Quasars from UKIDSS

The largest K-band flux-limited sample of luminous quasars to date has been constructed from the UKIDSS Large Area Survey Early Data Release, covering an effective area of 12.8 deg^2. Exploiting the K-band excess of all quasars with respect to foreground stars, including quasars experiencing dust reddening and objects with non-standard SEDs, a list of targets suitable for spectroscopic follow-up observations with the AAOmega multi-object spectrograph is constructed, resulting in more than 200 confirmed AGN. KX-selection successfully identifies as quasar candidates objects that are excluded from the SDSS quasar selection algorithm due to their colours being consistent with the stellar locus in optical colour space (with the space density of the excluded objects agreeing well with results from existing completeness analyses). Nearly half of the KX-selected quasars with K<17.0 at z<3 are too faint in the i-band to have been targeted by the SDSS quasar selection algorithm, revealing a large population of quasars with red i-K colours. The majority of these objects have significant amounts of host galaxy light contributing to their K-band magnitudes, consistent with previous predictions. The remaining objects are morphologically stellar and have colours consistent with quasars experiencing SMC-type reddening with 0.10<E(B-V)<0.25. The i-K colour distribution indicates that <10 per cent of the quasar population is missing from this K-band selected sample due to dust reddening, and comparisons with simulations strongly favour an obscured fraction of <20 per cent. (Abridged)Comment: 22 pages, 18 figures, accepted for publication in MNRAS. Resolution of Figure 2 has been reduced for astro-ph submission. The complete Table 5 can be found at http://www.aip.de/People/nmaddox/KX/catalogue.tx

Introduction to the Special Issue on Transforming Practices: Emancipatory Approaches to Youth Engagement

This Special Issue of the International Journal of Child, Youth and Family Studies focuses on emancipatory approaches to youth engagement. Evoking ideas of freedom, release, and liberation, we explore youth engagement as a means to facilitate social change, to improve organizations, and to build healthier communities. Broadening and deepening youth engagement beyond a shift from youth as objects to subjects necessarily entails youth workers and educators grappling with the significance of engaging in respectful and transformative youth-adult relationships. In taking up this agenda, youth and adults collaboratively explore opportunities and obstacles, and make recommendations for extending youth engagement beyond a mere trend or project, to constitute a value system that underlies practice

Prevention and Screening for Cardiometabolic Disease Following Hypertensive Disorders in Pregnancy in Low-Resource Settings:A Systematic Review and Delphi Study

Hypertensive disorders in pregnancy (HDP) and cardiometabolic and kidney diseases are rising in low- and middle-income countries (LMICs). While HDP are risk factors for cardiometabolic and kidney diseases, cost-effective, scalable strategies for screening and prevention in women with a history of HDP are lacking. Existing guidelines and recommendations require adaptation to LMIC settings. This article aims to generate consensus-based recommendations for the prevention and screening of cardiometabolic and kidney diseases tailored for implementation in LMICs. We conducted a systematic review of guidelines and recommendations for prevention and screening strategies for cardiometabolic and chronic kidney diseases following HDP. We searched PubMed/Medline, Embase and Cochrane Library for relevant articles and guidelines published from 2010 to 2021 from both high-income countries (HICs) and LMICs. No other filters were applied. References of included articles were also assessed for eligibility. Findings were synthesized narratively. The summary of guiding recommendations was subjected to two rounds of Delphi consensus surveys with experts experienced in LMIC settings. Fifty-four articles and 9 guidelines were identified, of which 25 were included. Thirty-five clinical recommendations were synthesized from these and classified into six domains: identification of women with HDP (4 recommendations), timing of first counseling and provision of health education (2 recommendations), structure and care setting (12 recommendations), information and communication needs (5 recommendations), cardiometabolic biomarkers (8 recommendations) and biomarkers thresholds (4 recommendations). The Delphi panel reached consensus on 33 final recommendations. These recommendations for health workers in LMICs provide practical and scalable approaches for effective screening and prevention of cardiometabolic disease following HDP. Monitoring and evaluation of implementation of these recommendations provide opportunities for reducing the escalating burden of noncommunicable diseases in LMICs

The Optical and Near-Infrared Properties of 2837 Quasars in the UKIRT Infrared Deep Sky Survey (UKIDSS)

The UKIRT Infrared Deep Sky Survey (UKIDSS) is the first of a new generation of hemispheric imaging projects to extend the work of the Two Micron All Sky Survey (2MASS) by reaching three magnitudes deeper in YJHK imaging, to K=18.2 (5-sigma, Vega) over wide fields. Better complementing existing optical surveys such as the Sloan Digital Sky Survey (SDSS), the resulting public imaging catalogues provide new photometry of rare object samples too faint to be reached previously. The first data release of UKIDSS has already surpassed 2MASS in terms of photons gathered, and using this new dataset we examine the near-infrared properties of 2837 quasars found in the SDSS and newly catalogued by the UKIDSS in ~189 square degrees. The matched quasars include the RA range 22hr to 4hr on the Southern Equatorial Stripe (SDSS Stripe 82), an area of significant future followup possibilities with deeper surveys and pointed observations. The sample covers the redshift and absolute magnitude ranges 0.08<z<5.03 and -29.5<M_i<-22.0, and 98 per cent of SDSS quasars have matching UKIDSS data. We discuss the photometry, astrometry, and various colour properties of the quasars. We also examine the effectiveness of quasar/star separation using the near-infrared passbands. The combination of SDSS ugriz photometry with the YJHK near-infrared photometry from UKIDSS over large areas of sky has enormous potential for advancing our understanding of the quasar population.Comment: Accepted for publication in MNRAS, 11 pages, 13 figures, full resolution figures available for download (see links in text

Development and replication of objective measurements of social visual engagement to aid in early diagnosis and assessment of autism

IMPORTANCE: Autism spectrum disorder is a common and early-emerging neurodevelopmental condition. While 80% of parents report having had concerns for their child\u27s development before age 2 years, many children are not diagnosed until ages 4 to 5 years or later. OBJECTIVE: To develop an objective performance-based tool to aid in early diagnosis and assessment of autism in children younger than 3 years. DESIGN, SETTING, AND PARTICIPANTS: In 2 prospective, consecutively enrolled, broad-spectrum, double-blind studies, we developed an objective eye-tracking-based index test for children aged 16 to 30 months, compared its performance with best-practice reference standard diagnosis of autism (discovery study), and then replicated findings in an independent sample (replication study). Discovery and replication studies were conducted in specialty centers for autism diagnosis and treatment. Reference standard diagnoses were made using best-practice standardized protocols by specialists blind to eye-tracking results. Eye-tracking tests were administered by staff blind to clinical results. Children were enrolled from April 27, 2013, until September 26, 2017. Data were analyzed from March 28, 2018, to January 3, 2019. MAIN OUTCOMES AND MEASURES: Prespecified primary end points were the sensitivity and specificity of the eye-tracking-based index test compared with the reference standard. Prespecified secondary end points measured convergent validity between eye-tracking-based indices and reference standard assessments of social disability, verbal ability, and nonverbal ability. RESULTS: Data were collected from 1089 children: 719 children (mean [SD] age, 22.4 [3.6] months) in the discovery study, and 370 children (mean [SD] age, 25.4 [6.0] months) in the replication study. In discovery, 224 (31.2%) were female and 495 (68.8%) male; in replication, 120 (32.4%) were female and 250 (67.6%) male. Based on reference standard expert clinical diagnosis, there were 386 participants (53.7%) with nonautism diagnoses and 333 (46.3%) with autism diagnoses in discovery, and 184 participants (49.7%) with nonautism diagnoses and 186 (50.3%) with autism diagnoses in replication. In the discovery study, the area under the receiver operating characteristic curve was 0.90 (95% CI, 0.88-0.92), sensitivity was 81.9% (95% CI, 77.3%-85.7%), and specificity was 89.9% (95% CI, 86.4%-92.5%). In the replication study, the area under the receiver operating characteristic curve was 0.89 (95% CI, 0.86-0.93), sensitivity was 80.6% (95% CI, 74.1%-85.7%), and specificity was 82.3% (95% CI, 76.1%-87.2%). Eye-tracking test results correlated with expert clinical assessments of children\u27s individual levels of ability, explaining 68.6% (95% CI, 58.3%-78.6%), 63.4% (95% CI, 47.9%-79.2%), and 49.0% (95% CI, 33.8%-65.4%) of variance in reference standard assessments of social disability, verbal ability, and nonverbal cognitive ability, respectively. CONCLUSIONS AND RELEVANCE: In two diagnostic studies of children younger than 3 years, objective eye-tracking-based measurements of social visual engagement quantified diagnostic status as well as individual levels of social disability, verbal ability, and nonverbal ability in autism. These findings suggest that objective measurements of social visual engagement can be used to aid in autism diagnosis and assessment

A strong redshift dependence of the broad absorption line quasar fraction

We describe the application of non-negative matrix factorisation to generate compact reconstructions of quasar spectra from the Sloan Digital Sky Survey (SDSS), with particular reference to broad absorption line quasars (BALQSOs). BAL properties are measured for SiIV lambda1400, CIV lambda1550, AlIII lambda1860 and MgII lambda2800, resulting in a catalogue of 3547 BALQSOs. Two corrections, based on extensive testing of synthetic BALQSO spectra, are applied in order to estimate the intrinsic fraction of CIV BALQSOs. First, the probability of an observed BALQSO spectrum being identified as such by our algorithm is calculated as a function of redshift, signal-to-noise ratio and BAL properties. Second, the different completenesses of the SDSS target selection algorithm for BALQSOs and non-BAL quasars are quantified. Accounting for these selection effects the intrinsic CIV BALQSO fraction is 41+/-5 per cent. Our analysis of the selection effects allows us to measure the dependence of the intrinsic CIV BALQSO fraction on luminosity and redshift. We find a factor of 3.5+/-0.4 decrease in the intrinsic fraction from the highest redshifts, z~4.0, down to z~2.0. The redshift dependence implies that an orientation effect alone is not sufficient to explain the presence of BAL troughs in some but not all quasar spectra. Our results are consistent with the intrinsic BALQSO fraction having no strong luminosity dependence, although with 3-sigma limits on the rate of change of the intrinsic fraction with luminosity of -6.9 and 7.0 per cent dex^-1 we are unable to rule out such a dependence.Comment: MNRAS in press; 28 pages, 28 figures; full data table is available until Sep 2011 at www.ast.cam.ac.uk/~jta/papers/bal_nmf_table1.da

Reconstructing the demographic history of orang-utans using Approximate Bayesian Computation

Investigating how different evolutionary forces have shaped patterns of DNA variation within and among species requires detailed knowledge of their demographic history. Orang-utans, whose distribution is currently restricted to the South-East Asian islands of Borneo (Pongo pygmaeus) and Sumatra (Pongo abelii), have likely experienced a complex demographic history, influenced by recurrent changes in climate and sea levels, volcanic activities and anthropogenic pressures. Using the most extensive sample set of wild orang-utans to date, we employed an Approximate Bayesian Computation (ABC) approach to test the fit of 12 different demographic scenarios to the observed patterns of variation in autosomal, X-chromosomal, mitochondrial and Y-chromosomal markers. In the best-fitting model, Sumatran orang-utans exhibit a deep split of populations north and south of Lake Toba, probably caused by multiple eruptions of the Toba volcano. In addition, we found signals for a strong decline in all Sumatran populations ~24 ka, probably associated with hunting by human colonizers. In contrast, Bornean orang-utans experienced a severe bottleneck ~135 ka, followed by a population expansion and substructuring starting ~82 ka, which we link to an expansion from a glacial refugium. We showed that orang-utans went through drastic changes in population size and connectedness, caused by recurrent contraction and expansion of rainforest habitat during Pleistocene glaciations and probably hunting by early humans. Our findings emphasize the fact that important aspects of the evolutionary past of species with complex demographic histories might remain obscured when applying overly simplified models

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