1,581 research outputs found
A Concept for Attribute-Based Authorization on D-Grid Resources
In Germany's D-Grid project numerous Grid communities are working together to provide a common overarching Grid infrastructure. The major aims of D-Grid are the integration of existing Grid deployments and their interoperability. The challenge lies in the heterogeneity of the current implementations: three Grid middleware stacks and different Virtual Organization management approaches have to be embraced to achieve the intended goals. In this article we focus oil the implementation of an attribute-based authorization infrastructure that not only leverages the well-known VO attributes but also campus attributes managed by a Shibboleth federation
Local orientations of fluctuating fluid interfaces
Thermal fluctuations cause the local normal vectors of fluid interfaces to
deviate from the vertical direction defined by the flat mean interface
position. This leads to a nonzero mean value of the corresponding polar tilt
angle which renders a characterization of the thermal state of an interface.
Based on the concept of an effective interface Hamiltonian we determine the
variances of the local interface position and of its lateral derivatives. This
leads to the probability distribution functions for the metric of the interface
and for the tilt angle which allows us to calculate its mean value and its mean
square deviation. We compare the temperature dependences of these quantities as
predicted by the simple capillary wave model, by an improved phenomenological
model, and by the microscopic effective interface Hamiltonian derived from
density functional theory. The mean tilt angle discriminates clearly between
these theoretical approaches and emphasizes the importance of the variation of
the surface tension at small wave lengths. Also the tilt angle two-point
correlation function is determined which renders an additional structural
characterization of interfacial fluctuations. Various experimental accesses to
measure the local orientational fluctuations are discussed.Comment: 29 pages, 12 figure
Wind reversals in turbulent Rayleigh-Benard convection
The phenomenon of irregular cessation and subsequent reversal of the
large-scale circulation in turbulent Rayleigh-B\'enard convection is
theoretically analysed. The force and thermal balance on a single plume
detached from the thermal boundary layer yields a set of coupled nonlinear
equations, whose dynamics is related to the Lorenz equations. For Prandtl and
Rayleigh numbers in the range and 10^{7} \leq
\Ra \leq 10^{12}, the model has the following features: (i) chaotic reversals
may be exhibited at Ra ; (ii) the Reynolds number based on the
root mean square velocity scales as \Re_{rms} \sim \Ra^{[0.41 ...
0.47]} (depending on Pr), and as
(depending on Ra); and (iii) the mean reversal frequency follows an effective
scaling law \omega / (\nu L^{-2}) \sim \Pr^{-(0.64 \pm 0.01)} \Ra^{0.44 \pm
0.01}. The phase diagram of the model is sketched, and the observed
transitions are discussed.Comment: 4 pages, 5 figure
Dealing with Uncertainties in Asteroid Deflection Demonstration Missions: NEOTwIST
Deflection missions to near-Earth asteroids will encounter non-negligible
uncertainties in the physical and orbital parameters of the target object. In
order to reliably assess future impact threat mitigation operations such
uncertainties have to be quantified and incorporated into the mission design.
The implementation of deflection demonstration missions offers the great
opportunity to test our current understanding of deflection relevant
uncertainties and their consequences, e.g., regarding kinetic impacts on
asteroid surfaces. In this contribution, we discuss the role of uncertainties
in the NEOTwIST asteroid deflection demonstration concept, a low-cost kinetic
impactor design elaborated in the framework of the NEOShield project. The aim
of NEOTwIST is to change the spin state of a known and well characterized
near-Earth object, in this case the asteroid (25143) Itokawa. Fast events such
as the production of the impact crater and ejecta are studied via cube-sat
chasers and a flyby vehicle. Long term changes, for instance, in the asteroid's
spin and orbit, can be assessed using ground based observations. We find that
such a mission can indeed provide valuable constraints on mitigation relevant
parameters. Furthermore, the here proposed kinetic impact scenarios can be
implemented within the next two decades without threatening Earth's safety.Comment: Accepted for publication in the proceedings of the IAUS 318 -
Asteroids: New Observations, New Models, held at the IAU General Assembly in
Honolulu, Hawaii, USA 201
Integrated control of wood destroying basidiomycetes combining Cu-based wood preservatives and Trichoderma spp
[EN] The production of new generation of wood preservatives (without addition of a co-biocide) in combination with an exchange of wood poles on identical sites with high fungal inoculum, has resulted in an increase of premature failures of wood utility poles in the last decades. Wood destroying basidiomycetes inhabiting sites where poles have been installed, have developed resistance against wood preservatives. The objective of the in vitro studies was to identify a Trichoderma spp. with a highly antagonistic potential against wood destroying basidiomycetes that is capable of colonizing Cu-rich environments. For this purpose, the activity of five Trichoderma spp. on Cu-rich medium was evaluated according to its growth and sporulation rates. The influence of the selected Trichoderma spp. on wood colonization and degradation by five wood destroying basidiomycetes was quantitatively analyzed by means of dry weight loss of wood specimens. Furthermore, the preventative effect of the
selected Trichoderma spp. in combination with four Cu-based preservatives was also examined by mass loss and histological changes in the wood specimens. Trichoderma harzianum (T-720) was considered the biocontrol agent with higher antagonistic potential to colonize Cu-rich environments (up to 0.1% CuSO4 amended medium). T. harzianum demonstrated significant preventative effect on wood specimens against four wood destroying basidiomycetes. The combined effect of T. harzianum and Cu-based wood preservatives demonstrated that after 9 months incubation with two wood destroying basidiomycetes, wood specimens treated with 3.8 kg m-3 copper-chromium had weight losses between 55±65%, whereas containers previously treated with T. harzianum had significantly lower weight losses (0±25%). Histological studies on one of the wood destroying basidiomycetes
revealed typical decomposition of wood cells by brown-rot fungi in Cu-impregnated samples, that were notably absent in wood specimens previously exposed to T. harzianum. It is concluded that carefully selected Trichoderma isolates can be used for integrated wood protection against a range of wood destroying basidiomycetes and may have potential for integrated wood protection in the field.The authors are pleased to acknowledge the financial support by the Swiss CTI (Project No. 17001.1 PFLS-LS).Ribera, J.; Fink, S.; Bas Cerdá, MDC.; Schwarze, FWMR. (2017). Integrated control of wood destroying basidiomycetes combining Cu-based wood preservatives and Trichoderma spp. PLoS ONE. 12(4). https://doi.org/10.6084/m9.figshare.4743061S12
What would an 'ideal' glaucoma examination be like? - A conjoint analysis of patients' and physicians' preferences
PURPOSE To structurally determine patients' and physicians' preferences for glaucoma diagnostic methods in order to improve glaucoma patient care and improve patient compliance with follow-up visits. METHODS Forty-one patients with glaucoma and 32 ophthalmologists were included in this cross-sectional study. Profiles representing glaucoma examinations were created using conjoint analysis (CA). The following factors of a glaucoma examination method were evaluated: (1) examination comfort, (2) examination frequency, (3) follow-up examination necessary in case of suspicious result, (4) cost for the patient, (5) travel time to examination site, (6) sensitivity and (7) specificity of the examination method. RESULTS Preferences were highest in both groups for examination sensitivity, followed by cost and specificity for the patient group. For the physician group, specificity was second most important, followed by cost. Least important was travel time for the patients and follow-up examinations for the physicians. CONCLUSIONS Participants would rather pay more and travel longer to get a highly sensitive examination. This form of care is present in university eye hospitals. Consequently, it would be advisable to enhance capacities of these centers. Outpatient practices that offer glaucoma service should be fully equipped and should employ a glaucoma specialist
Non-Oberbeck-Boussinesq effects in turbulent thermal convection in ethane close to the critical point
As shown in earlier work (Ahlers et al., J. Fluid Mech. 569, p.409 (2006)),
non-Oberbeck Boussinesq (NOB) corrections to the center temperature in
turbulent Rayleigh-Benard convection in water and also in glycerol are governed
by the temperature dependences of the kinematic viscosity and the thermal
diffusion coefficient. If the working fluid is ethane close to the critical
point the origin of non-Oberbeck-Boussinesq corrections is very different, as
will be shown in the present paper. Namely, the main origin of NOB corrections
then lies in the strong temperature dependence of the isobaric thermal
expansion coefficient \beta(T). More precisely, it is the nonlinear
T-dependence of the density \rho(T) in the buoyancy force which causes another
type of NOB effect. We demonstrate that through a combination of experimental,
numerical, and theoretical work, the latter in the framework of the extended
Prandtl-Blasius boundary layer theory developed in Ahlers et al., J. Fluid
Mech. 569, p.409 (2006). The latter comes to its limits, if the temperature
dependence of the thermal expension coefficient \beta(T) is significant.Comment: 18 pages, 15 figures, 3 table
The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction. The aim of this study was to elucidate further the underlying mechanisms responsible for dysfunctional T-cells and their interaction with APCs following trauma-hemorrhage.
Design: Adult C3H/HeN male mice were subjected to trauma-hemorrhage (3-cm midline laparotomy) followed by hemorrhage (blood pressure of 35�5mmHg for 90 min and resuscitation) or sham operation. At 24 h thereafter, spleens were harvested and T-cells (by Microbeads) and APCs (via adherence) were Isolated. Co-cultures of T-cells and APCs were established for 48 h and stimulated with concanavalin A and lipopolysaccharide. T-Cell specific cytokines known to affect APC function (i.e. interleukin(IL)-2, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF)) were measured in culture supernatants by Multiplex assay. The expression of MHC class II as well as co-stimulatory surface molecules on T-cells and APCs was determined by flow cytometry.
Results: The release of IL-4 and GM-CSF by T-cells was suppressed following trauma-hemorrhage, irrespective of whether sham or trauma-hemorrhage APCs were present. Antigen-presenting cells from animals subjected to trauma-hemorrhage did not affect T-cell derived cytokine release by sham T-cells. In contrast, T-cells from traumahemorrhage animals depressed MHC class II expression of CD11c(þ) cells, irrespective of whether APCs underwent sham or trauma-hemorrhage procedure. Surprisingly, co-stimulatory molecules on APCs (CD80, CD86) were not affected by trauma-hemorrhage.
Conclusions: These results suggest that beside IFN-g other T-cell derived cytokines contribute to immunosuppression following trauma-hemorrhage causing diminished MHC II expression on APCs. Thus, T-cells appear to play an important role in this interaction at the time-point examined. Therapeutic approaches should aim at maintenance of T-cell function and their interaction with APCs to prevent extended immunosuppression following trauma-hemorrhage
Variational bound on energy dissipation in plane Couette flow
We present numerical solutions to the extended Doering-Constantin variational
principle for upper bounds on the energy dissipation rate in turbulent plane
Couette flow. Using the compound matrix technique in order to reformulate this
principle's spectral constraint, we derive a system of equations that is
amenable to numerical treatment in the entire range from low to asymptotically
high Reynolds numbers. Our variational bound exhibits a minimum at intermediate
Reynolds numbers, and reproduces the Busse bound in the asymptotic regime. As a
consequence of a bifurcation of the minimizing wavenumbers, there exist two
length scales that determine the optimal upper bound: the effective width of
the variational profile's boundary segments, and the extension of their flat
interior part.Comment: 22 pages, RevTeX, 11 postscript figures are available as one
uuencoded .tar.gz file from [email protected]
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