Extended Transfer Bound Error Analysis for Parametric Channel withContinuous Valued Correlated Random Nuisance Parameter

In this paper, we address the extended use of transfer bound analysis of bit error rate (BER) properties. In conjunction with proper parameter modeling, we offer a method to resolve the problem of transfer bound applicability on a system with random and possibly correlated continuous value nuisance parameters. We introduce a new additional parameter space into the original error space and join them in a product matrix for an extended transfer function evaluation. Example applications with simple trellis code for Rayleigh fading channel and phase synchronization error are investigated to demonstrate the functionality of the proved principle. Computer simulation results are presented for two different codes and various fading scenarios, and comparisons are made among analytical and measured system error performances

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis

Aims/hypothesis FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in polycystic ovary syndrome (PCOS). We therefore aimed to examine the impact of FTO genotype on BMI and weight in PCOS. Methods A systematic search of medical databases (PubMed, EMBASE and Cochrane CENTRAL) was conducted up to the end of April 2011. Seven studies describing eight distinct PCOS cohorts were retrieved; seven were genotyped for SNP rs9939609 and one for SNP rs1421085. The per allele effect on BMI and body weight increase was calculated and subjected to meta-analysis. Results A total of 2,548 women with PCOS were included in the study; 762 were TT homozygotes, 1,253 had an AT/CT genotype, and 533 were AA/CC homozygotes. Each additional copy of the effect allele (A/C) increased the BMI by a mean of 0.19 z score units (95% CI 0.13, 0.24; p = 2.26 × 10−11) and body weight by a mean of 0.20 z score units (95% CI 0.14, 0.26; p = 1.02 × 10−10). This translated into an approximately 3.3 kg/m2 increase in BMI and an approximately 9.6 kg gain in body weight between TT and AA/CC homozygotes. The association between FTO genotypes and BMI was stronger in the cohorts with PCOS than in the general female populations from large genome-wide association studies. Deviation from an additive genetic model was observed in heavier populations. Conclusions/interpretation The effect of FTO SNPs on obesity-related traits in PCOS seems to be more than two times greater than the effect found in large population-based studies. This suggests an interaction between FTO and the metabolic context or polygenic background of PCOS

Wearable wireless inertial measurement for sports applications

The advent of MEMS inertial sensors has reduced the size, cost and power requirements of 6 Degrees-of-Freedom inertial measurement systems to a level where their use can be considered for wearable wireless monitoring devices. Many applications for such Wearable Wireless Inertial Measurement Units exist in the area of sports and sports science. Such a system would be critical in providing data for the analysis of the kinematic motion data of an athlete - to characterise a player’s technique or track progress and provide accurate, quantitative feedback to player and coach in near real time. A small, lightweight and low power device with the ability to sense the full range of human motion at a high sampling rate is required for such applications. It must also be robust, well sealed and comfortable to wear. Further development and miniaturisation of such devices coupled with progress in energy scavenging may lead to their use in other areas and their near ubiquity, with the potential to be embedded within clothes, buildings, materials, objects and people for health monitoring, location tracking and other purpose

Extended Transfer Bound Error Analysis for Parametric Channel withContinuous Valued Correlated Random Nuisance Parameter

In this paper, we address the extended use of transfer boundanalysis of bit error rate (BER) properties. In conjunction with properparameter modeling, we offer a method to resolve the problem oftransfer bound applicability on a system with random and possiblycorrelated continuous value nuisance parameters. We introduce a newadditional parameter space into the original error space and join themin a product matrix for an extended transfer function evaluation.Example applications with simple trellis code for Rayleigh fadingchannel and phase synchronization error are investigated to demonstratethe functionality of the proved principle. Computer simulation resultsare presented for two different codes and various fading scenarios, andcomparisons are made among analytical and measured system errorperformances

A novel RET/PTC variant detected in a pediatric patient with papillary thyroid cancer without ionization history

Molecular tumour pathology - and tumour genetic