534 research outputs found
Individualized study systems in theory and practice
After a short characterization of individualized study systems (ISS) and a survey of the number and subject fields of individualized courses in the USA and Europe, the construction and evaluation of an ISSystem in freshman mathematics at the Twente University of Technology is discussed. On the basis of their own experience and data received from others, the authors present a scheme in which the main characteristics of successful ISSystems are outlined
Microfabrics and deformation processes in magmatic veins of the Thuringian Forest, Germany
The research area is located in the
Ruhla-Brotterode crystalline complex in the western part of the Thuringian
Forest (Germany), about 20km southsouthwest
of Eisenach. The investigated
outcrops occur at the eastern and western
flanks of the valleys north of the
villages Trusetal and Hohleborn. Deformed
magmatic veins only occur in
the Hohleborn area. Both areas have
relative fresh outcropping rocks, due to
the steep relief, former quarries and
fresh road cuts. According to Obst
& Katzung (2000) several periods with
the formation of magmatic veins with
different chemical composition occur in
the Ruhla-Brotterode crystalline complex.
Presumably older lamprophyric
veins and younger doleritic, syenitporphyric
and granitporphyric veins have
been identified (Obst & Katzung 2000).
Benek & Schust (1988) already pointed
out that some of these magmatic veins
have experienced ductile deformation.
The subject of this work is the occurrence
of deformed magmatic veins
in the Hohleborn area. The contact
to their host rocks, their petrography
and their microfabrics have been investigated
and related to deformation processes,
which led to a better understanding
of their deformation conditions
within the late-to post-variscan development
of the area.conferenc
The nationwide case-cohort study in pharmacoepidemiology: a study of iatrogenic anaphylaxis and agranulocytosis
Drug safety is an important palt of postmarketing surveillance. In ancient
times, people were already aware of the fact that drugs could have side effects.
The oldest drugs were mainly of plant and animal origin, but also mercury,
arsenic and antimony were used, the toxic effects of which were well known.
In 1224 Frederick II, Emperor of Hohenstaufen ordered inspection of drugs
and mixtures prepared by apothecaries and in 1518 the Royal college of
Physicians was founded, whose Fellows were also concemed with quality
control of drugs. The first drug to be banned because of its toxicity was
antimony in the 17th century. It was used again, however, after it cured Louis
XIV from typhoid fever.
One of the first descriptions of an intoxication to a drug which is still in use
today, was made by William Withering in 1785. He described digitalis
intoxication as follows: "The Foxglove, when given in very large and quickly
repeated doses, occasions sickness, vomiting, purging, giddiness, confused
vision, objects appearing green or yellow, increased secretion of urine with
frequent motions to patt with it, and sometimes inability to retain it; slow
pulse, even as low as 35 in a minute, cold sweats, convulsions, syncope and
death"
Sociale interactie en gemeenschapsgevoel in Meerhoven:Case study van twee hofjes met een mix van koopwoningen en sociale huurwoningen
Sociale interactie en gemeenschapsgevoel in Meerhoven:Case study van twee hofjes met een mix van koopwoningen en sociale huurwoningen
A non-invasive risk score including skin autofluorescence predicts diabetes risk in the general population
Abstract Increased skin autofluorescence (SAF) predicts the development of diabetes-related complications and cardiovascular disease. We assessed the performance of a simple model which includes SAF to identify individuals at high risk for undiagnosed and incident type 2 diabetes, in 58,377 participants in the Lifelines Cohort Study without known diabetes. Newly-diagnosed diabetes was defined as fasting blood glucose ≥ 7.0 mmol/l and/or HbA1c ≥ 6.5% (≥ 48 mmol/mol) or self-reported diabetes at follow-up. We constructed predictive models based on age, body mass index (BMI), SAF, and parental history of diabetes, and compared to results with the concise FINDRISC model. At 2nd visit to Lifelines, 1113 (1.9%) participants were identified with undiagnosed diabetes and 1033 (1.8%) participants developed diabetes during follow-up. A model comprising age, BMI and SAF yielded an AUC of 0.783 and was non-inferior to the concise FINDRISC model, which had an AUC of 0.797 to predict new diabetes. At a score of 5.8, sensitivity was 78% and specificity of 66%. Model 2 which also incorporated parental diabetes history, had an AUC of 0.792, and a sensitivity of 74% and specificity of 70% at a score of 6.5. Net reclassification index (NRI) did not improve significantly (NRI 1.43% (− 0.50–3.37 p = 0.15). The combination of an easy to perform SAF measurement with age and BMI is a good alternative screening tool suitable for medical and non-medical settings. Parental history of diabetes did not significantly improve model performance in this homogeneous cohort
Offline and online scheduling of electric vehicle charging with a minimum charging threshold
The increasing penetration of electric vehicles (EVs) requires the development of smart charging strategies that accommodate the increasing load of these EVs on the distribution grid. Many existing charging strategies assume that an EV is allowed to charge at any rate up to a given maximum rate. However, in practice, charging at low rates is inefficient and often even impossible. Therefore, this paper presents an efficient algorithm for scheduling an EV within a decentralized energy management system that allows only charging above a given threshold. We show that the resulting optimal EV schedule is characterized by an activation level and a fill-level. Moreover, based on this result, we derive an online approach that does not require predictions of uncontrollable loads as input, but merely a prediction of these two characterizing values. Simulation results show that the online algorithm is robust against prediction errors in these values and can produce near-optimal online solutions
Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes
BACKGROUND: Skin autofluorescence (SAF) is a non-invasive measure reflecting accumulation of advanced glycation endproducts (AGEs) in the skin. Higher SAF levels are associated with an increased risk of developing type 2 diabetes and cardiovascular disease. An earlier genome-wide association study (GWAS) revealed a strong association between NAT2 variants and SAF. The aim of this study was to calculate SAF heritability and to identify additional genetic variants associated with SAF through genome-wide association studies (GWAS). RESULTS: In 27,534 participants without diabetes the heritability estimate of lnSAF was 33% ± 2.0% (SE) in a model adjusted for covariates. In meta-GWAS for lnSAF five SNPs, on chromosomes 8, 11, 15 and 16 were associated with lnSAF (P  T), which results in a Met30Val missense variant in MMP27 exon 1 (NM_022122.3); 2. rs2470893 (Chr15:75,019,449,C > T), in intergenic region between CYP1A1 and CYP1A2; with attenuation of the SNP-effect when coffee consumption was included as a covariate; 3. rs12931267 (Chr16:89,818,732,C > G) in intron 30 of FANCA and near MC1R; and following conditional analysis 4. rs3764257 (Chr16:89,800,887,C > G) an intronic variant in ZNF276, 17.8 kb upstream from rs12931267; finally, 30 kb downstream from NAT2 5. rs576201050 (Chr8:18,288,053,G > A). CONCLUSIONS: This large meta-GWAS revealed five SNPs at four loci associated with SAF in the non-diabetes population. Further unravelling of the genetic architecture of SAF will help in improving its utility as a tool for screening and early detection of diseases and disease complications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-022-09062-x
The Association Between Anemia and Skin Autofluorescence, a Marker for Advanced Glycation End Product Accumulation
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