Colour unwound - disentangling colours for azimuthal asymmetries in Drell-Yan scattering

It has been suggested that a colour-entanglement effect exists in the Drell-Yan cross section for the 'double T-odd' contributions at low transverse momentum $Q_T$, rendering the colour structure different from that predicted by the usual factorisation formula [1]. These T-odd contributions can come from the Boer-Mulders or Sivers transverse momentum dependent distribution functions. The different colour structure should be visible already at the lowest possible order that gives a contribution to the double Boer-Mulders (dBM) or double Sivers (dS) effect, that is at the level of two gluon exchanges. To discriminate between the different predictions, we compute the leading-power contribution to the low-$Q_T$ dBM cross section at the two-gluon exchange order in the context of a spectator model. The computation is performed using a method of regions analysis with Collins subtraction terms implemented. The results conform with the predictions of the factorisation formula. In the cancellation of the colour entanglement, diagrams containing the three-gluon vertex are essential. Furthermore, the Glauber region turns out to play an important role - in fact, it is possible to assign the full contribution to the dBM cross section at the given order to the region in which the two gluons have Glauber scaling. A similar disentanglement of colour is found for the dS effect.Comment: 36 pages, 11 figures; v2: typos corrected/ reference added, v3: minor corrections/ small explanations added/ references added, v4: very minor correction/ small explanations added/ references added (this version has been accepted for publication in SciPost

Resolving HD 100546 disc in the mid-infrared: Small inner disc and asymmetry near the gap

A region of roughly half of the solar system scale around the star HD 100546 is largely cleared of gas and dust, in contrast to the bright outer disc. However, some material is observed in the immediate vicinity of the star. We investigate how the dust is distributed within and outside the gap, and constrain the disc geometry with mid-infrared interferometric observations using VLTI/MIDI. With baseline lengths of 40m, our long baseline observations are sensitive to the inner few AU from the star, and we combined them with observations at shorter, 15m baselines, to probe emission beyond the gap at up to 20AU from the star. We modelled the mid-infrared emission using radial temperature profiles. Our model is composed of infinitesimal concentric annuli emitting as black bodies, and it has distinct inner and outer disc components. We derived an upper limit of 0.7AU for the radial size of the inner disc, from our longest baseline data. This small dusty disc is separated from the edge of the outer disc by a large, roughly 10AU wide gap. Our short baseline data place a bright ring of emission at 11+-1AU, consistent with prior observations of the transition region between the gap and the outer disc, known as the disc wall. The inclination and position angle are constrained by our data to i=53+-8deg and PA=145+-5deg. Compared to the rim and outer disc geometry this suggests co-planarity. Brightness asymmetry is evident in both short and long baseline data, and it is unequivocally discernible from any atmospheric or instrumental effects. The origin of the asymmetry is consistent with the bright disc wall, which we find to be 1-2AU wide. The gap is cleared of micron-sized dust, but we cannot rule out the presence of larger particles and/or perturbing bodies.Comment: 12 pages, 9 figures, accepted for publication in A&

The influence of microgravity on invasive growth in Saccharomyces cerevisiae

This study investigates the effects of microgravity on colony growth and the morphological transition from single cells to short invasive filaments in the model eukaryotic organism Saccharomyces cerevisiae. Two-dimensional spreading of the yeast colonies grown on semi-solid agar medium was reduced under microgravity in the Sigma 1278b laboratory strain but not in the CMBSESA1 industrial strain. This was supported by the Sigma 1278b proteome map under microgravity conditions, which revealed upregulation of proteins linked to anaerobic conditions. The Sigma 1278b strain showed a reduced invasive growth in the center of the yeast colony. Bud scar distribution was slightly affected, with a switch toward more random budding. Together, microgravity conditions disturb spatially programmed budding patterns and generate strain-dependent growth differences in yeast colonies on semi-solid medium

Use of sepsis-related diagnostic criteria in primary care:a survey among general practitioners

BACKGROUND: Use of sepsis-criteria in hospital settings is effective in realizing early recognition, adequate treatment and reduction of sepsis-associated morbidity and mortality. Whether general practitioners (GPs) use these diagnostic criteria is unknown. OBJECTIVE: To gauge the knowledge and use of various diagnostic criteria. To determine which parameters GPs associate with an increased likelihood of sepsis. METHODS: Two thousand five hundred and sixty GPs were invited and 229 agreed to participate in a survey, reached out to through e-mail and WhatsApp groups. The survey consisted of two parts: the first part aimed to obtain information about the GP, training and knowledge about sepsis recognition, and the second part tested specific knowledge using six realistic cases. RESULTS: Two hundred and six questionnaires, representing a response rate of 8.1%, were eligible for analysis. Gut feeling (98.1%) was the most used diagnostic method, while systemic inflammatory response syndrome (37.9%), quick Sequential Organ Failure Assessment (qSOFA) (7.8%) and UK Sepsis Trust criteria (UKSTc) (1.5%) were used by the minority of the GPs. Few of the responding GPs had heard of either the qSOFA (27.7%) or the UKSTc (11.7%). Recognition of sepsis varied greatly between GPs. GPs most strongly associated the individual signs of the qSOFA (mental status, systolic blood pressure, capillary refill time and respiratory rate) with diagnosing sepsis in the test cases. CONCLUSIONS: GPs mostly use gut feeling to diagnose sepsis and are frequently not familiar with the 'sepsis-criteria' used in hospital settings, although clinical reasoning was mostly in line with the qSOFA score. In order to improve sepsis recognition in primary care, GPs should be educated in the use of available screening tools

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature

Rationale: When compared to other types of cancer, the prevalence of midgut neuroendocrine tumors (NET) has disproportionally increased over the past decades. To date, there has been very little progress in discovering (epi)genetic drivers and treatment options for these tumors. Recent microbiome research has revealed that enteroendocrine cells communicate with the intestinal microbiome and has provided novel treatment targets for various other cancer types. Hence, our aim was to analyze the role of the gut microbiome in midgut NET patients. Methods: Fecal samples, prospectively collected from patients and control subjects, were analyzed with next generation 16S sequencing. Patients with neuroendocrine carcinomas and recent antibiotics use were excluded. Relevant variables were extracted from questionnaires and electronic health records. Microbial composition was compared between patients and controls as well as between groups within the patient cohort. Results: 87 midgut NET patients and 95 controls were included. Midgut NET patients had a less rich and diverse gut microbiome than controls (p &lt; 0.001). Moreover, we identified 31 differentially abundant species and a gut microbial signature consisting of 17 species that was predictive of midgut NET presence with an area under the receiver operating characteristic curve of 0.863. Gut microbial composition was not directly associated with the presence of the carcinoid syndrome, tumor grade or multifocality. Nonetheless, we did observe a potential link between microbial diversity and the presence of carcinoid syndrome symptoms within the subset of patients with elevated 5-hydroxyindolacetic acid levels. Conclusion: Midgut NET patients have an altered gut microbiome which suggests a role in NET development and could provide novel targets for microbiome-based diagnostics and therapeutics.</p

High-resolution ALMA observations of HD100546 : asymmetric circumstellar ring, and circumplanetary disk upper limits

We present long baseline Atacama Large Millimeter/submillimeter Array (ALMA) observations of the 870μm dust continuum emission and CO (3-2) from the protoplanetary disk around the Herbig Ae/Be star HD 100546, which is one of the few systems claimed to have two young embedded planets. These observations achieve a resolution of 4 au (3.8 mas), an rms noise of 66μJy/beam, and reveal an asymmetric ring between ∼20-40 au with largely optically thin dust continuum emission. This ring is well fit by two concentric and overlapping Gaussian rings of different widths and a Vortex. In addition, an unresolved component is detected at a position consistent with the central star, which may trace the central inner disk (<2au in radius). We report a lack of compact continuum emission at the positions of both claimed protoplanets. We use this result to constrain the circumplanetary disk (CPD) mass and size of 1.44MEarth and 0.44au in the optically thin and thick regime, respectively, for the case of the previously directly imaged protoplanet candidate at ∼55 au (HD100546 b). We compare these empirical CPD constraints to previous numerical simulations. This suggests that HD100546 b is inconsistent with several planet accretion models, while gas-starved models are also still compatible. We estimate the planetary mass as 1.65 MJ by using the relation between planet, circumstellar, and circumplanetary masses derived from numerical simulations. Finally, the CO integrated intensity map shows a possible spiral arm feature that would match the spiral features identified in Near-Infrared scattered light polarized emission, which suggests a real spiral feature in the disk surface that needs to be confirmed with further observations

Dust, Ice and Gas in Time (DIGIT) Herschel program first results: A full PACS-SED scan of the gas line emission in protostar DK Cha

DK Cha is an intermediate-mass star in transition from an embedded configuration to a star plus disk stage. We aim to study the composition and energetics of the circumstellar material during this pivotal stage. Using the Range Scan mode of PACS on the Herschel Space Observatory, we obtained a spectrum of DK Cha from 55 to 210 micron as part of the DIGIT Key Program. Almost 50 molecular and atomic lines were detected, many more than the 7 lines detected in ISO-LWS. Nearly the entire ladder of CO from J=14-13 to 38-37 (E_u/k = 4080 K), water from levels as excited as E_u/k = 843 K, and OH lines up to E_u/k = 290 K were detected. The continuum emission in our PACS SED scan matches the flux expected from a model consisting of a star, a surrounding disk of 0.03 Solar mass, and an envelope of a similar mass, supporting the suggestion that the object is emerging from its main accretion stage. Molecular, atomic, and ionic emission lines in the far-infrared reveal the outflow's influence on the envelope. The inferred hot gas can be photon-heated, but some emission could be due to C-shocks in the walls of the outflow cavity.Comment: 4 Page letter, To appear in A&A special issue on Hersche

Morphologic development of the first-trimester utero-placental vasculature is positively associated with embryonic and fetal growth:the Rotterdam Periconception Cohort

STUDY QUESTION: Is morphologic development of the first-trimester utero-placental vasculature associated with embryonic growth and development, fetal growth, and birth weight percentiles?SUMMARY ANSWER: Using the utero-placental vascular skeleton (uPVS) as a new imaging marker, this study reveals morphologic development of the first-trimester utero-placental vasculature is positively associated with embryonic growth and development, fetal growth, and birth weight percentiles. WHAT IS KNOWN ALREADY: First-trimester development of the utero-placental vasculature is associated with placental function, which subsequently impacts embryonic and fetal ability to reach their full growth potential. The attribution of morphologic variations in the utero-placental vascular development, including the vascular structure and branching density, on prenatal growth remains unknown. STUDY DESIGN, SIZE, DURATION: This study was conducted in the VIRTUAL Placental study, a subcohort of 214 ongoing pregnancies, embedded in the prospective observational Rotterdam Periconception Cohort (Predict study). Women were included before 10 weeks gestational age (GA) at a tertiary referral hospital in The Netherlands between January 2017 and March 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS: We obtained three-dimensional power Doppler volumes of the gestational sac including the embryo and the placenta at 7, 9, and 11 weeks of gestation. Virtual Reality-based segmentation and a recently developed skeletonization algorithm were applied to the power Doppler volumes to generate the uPVS and to measure utero-placental vascular volume (uPVV). Absolute vascular morphology was quantified by assigning a morphologic characteristic to each voxel in the uPVS (i.e. end-, bifurcation-crossing-, or vessel point). Additionally, total vascular length (mm) was calculated. The ratios of the uPVS characteristics to the uPVV were calculated to determine the density of vascular branching. Embryonic growth was estimated by crown-rump length and embryonic volume. Embryonic development was estimated by Carnegie stages. Fetal growth was measured by estimated fetal weight in the second and third trimester and birth weight percentiles. Linear mixed models were used to estimate trajectories of longitudinal measurements. Linear regression analysis with adjustments for confounders was used to evaluate associations between trajectories of the uPVS and prenatal growth. Groups were stratified for conception method (natural/IVF-ICSI conceptions), fetal sex (male/female), and the occurrence of placenta-related complications (yes/no). MAIN RESULTS AND THE ROLE OF CHANCE: Increased absolute vascular morphologic development, estimated by positive random intercepts of the uPVS characteristics, is associated with increased embryonic growth, reflected by crown-rump length (endpoints β = 0.017, 95% CI [0.009; 0.025], bifurcation points β = 0.012, 95% CI [0.006; 0.018], crossing points β = 0.017, 95% CI [0.008; 0.025], vessel points β = 0.01, 95% CI [0.002; 0.008], and total vascular length β = 0.007, 95% CI [0.003; 0.010], and similarly with embryonic volume and Carnegie stage, all P-values ≤ 0.01. Density of vascular branching was negatively associated with estimated fetal weight in the third trimester (endpoints: uPVV β = -94.972, 95% CI [-185.245; -3.698], bifurcation points: uPVV β = -192.601 95% CI [-360.532; -24.670]) and birth weight percentiles (endpoints: uPVV β = -20.727, 95% CI [-32.771; -8.683], bifurcation points: uPVV β -51.097 95% CI [-72.257; -29.937], and crossing points: uPVV β = -48.604 95% CI [-74.246; -22.961])), all P-values &lt; 0.05. After stratification, the associations were observed in natural conceptions specifically.LIMITATION, REASONS FOR CAUTION: Although the results of this prospective observational study clearly demonstrate associations between first-trimester utero-placental vascular morphologic development and prenatal growth, further research is required before we can draw firm conclusions about a causal relationship. WIDER IMPLICATIONS OF THE FINDINGS: Our findings support the hypothesis that morphologic variations in utero-placental vascular development play a role in the vascular mechanisms involved in embryonic and fetal growth and development. Application of the uPVS could benefit our understanding of the pathophysiology underlying placenta-related complications. Future research should focus on the clinical applicability of the uPVS as an imaging marker for the early detection of fetal growth restriction. STUDY FUNDING/COMPETING INTEREST(S): This research was funded by the Department of Obstetrics and Gynecology of the Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. There are no conflicts of interest. TRIAL REGISTRATION NUMBER: Registered at the Dutch Trial Register (NTR6854).</p

Relating jet structure to photometric variability: the Herbig Ae star HD 163296

Herbig Ae/Be stars are intermediate-mass pre-main sequence stars surrounded by circumstellar dust disks. Some are observed to produce jets, whose appearance as a sequence of shock fronts (knots) suggests a past episodic outflow variability. This "jet fossil record" can be used to reconstruct the outflow history. We present the first optical to near-infrared (NIR) VLT/X-shooter spectra of the jet from the Herbig Ae star HD 163296. We determine physical conditions in the knots, as well as their kinematic "launch epochs". Knots are formed simultaneously on either side of the disk, with a regular interval of ~16 yr. The velocity dispersion versus jet velocity and the energy input are comparable in both lobes. However, the mass loss rate, velocity, and shock conditions are asymmetric. We find Mjet/Macc ~ 0.01-0.1, consistent with magneto-centrifugal jet launching models. No evidence for dust is found in the high-velocity jet, suggesting it is launched within the sublimation radius (<0.5 au). The jet inclination measured from proper motions and radial velocities confirms it is perpendicular to the disk. A tentative relation is found between the structure of the jet and the photometric variability of the source. Episodes of NIR brightening were previously detected and attributed to a dusty disk wind. We report for the first time significant optical fadings lasting from a few days up to a year, coinciding with the NIR brightenings. These are likely caused by dust lifted high above the disk plane; this supports the disk wind scenario. The disk wind is launched at a larger radius than the high-velocity atomic jet, although their outflow variability may have a common origin. No significant relation between outflow and accretion variability could be established. Our findings confirm that this source undergoes periodic ejection events, which may be coupled with dust ejections above the disk plane.Comment: 20 pages, 11 figures, accepted for publication in Astronomy & Astrophysic