DEVELOPMENT AND VALIDATION OF CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL, AMLODIPINE BESYLATE, CILNIDIPINE IN COMBINATION TABLET DOSAGE FORM

Objective: To develop and validate a simple, sensitive and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of olmesartan medoxomil (OLM), amlodipine besylate (AML) and cilnidipine (CIL) in pharmaceutical tablet formulation.Methods: In this work we have taken 2 combinations, combination 1-OLM & AML and combination 2-OLM & CIL. HPLC analysis was carried out by using reverse phase isocratic elution with a C 18 column and a mobile phase of 0.05 M ammonium acetate, acetonitrile and methanol in the ratio of 30:50:20, v/v, pH was adjusted to 7.3. Detection of the analyte was achieved by using UV detector at 240 nm.Results: The retention time of olmesartan medoxomil, amlodipine besylate and cilnidipine were 2.2, 3 and 4.5 minutes respectively. Linearity of the method was found to be in the concentration range of 10-100µg/ml for olmesartan medoxomil, 5-50µg/ml for amlodipine and 10-100µg/ml for cilnidipine. The correlation coefficient value was greater than 0.999 for all the analytes.Conclusion: The method was validated as per ICH guidelines and is applied for the estimation of these components simultaneously in pharmaceutical tablet formulation.Â

A Survey on Biometrics and Cancelable Biometrics Systems

Now-a-days, biometric systems have replaced the password or token based authentication system in many fields to improve the security level. However, biometric system is also vulnerable to security threats. Unlike password based system, biometric templates cannot be replaced if lost or compromised. To deal with the issue of the compromised biometric template, template protection schemes evolved to make it possible to replace the biometric template. Cancelable biometric is such a template protection scheme that replaces a biometric template when the stored template is stolen or lost. It is a feature domain transformation where a distorted version of a biometric template is generated and matched in the transformed domain. This paper presents a review on the state-of-the-art and analysis of different existing methods of biometric based authentication system and cancelable biometric systems along with an elaborate focus on cancelable biometrics in order to show its advantages over the standard biometric systems through some generalized standards and guidelines acquired from the literature. We also proposed a highly secure method for cancelable biometrics using a non-invertible function based on Discrete Cosine Transformation (DCT) and Huffman encoding. We tested and evaluated the proposed novel method for 50 users and achieved good results

A Review on the Mechanical Modeling of Composite Manufacturing Processes

© 2016, The Author(s). The increased usage of fiber reinforced polymer composites in load bearing applications requires a detailed understanding of the process induced residual stresses and their effect on the shape distortions. This is utmost necessary in order to have more reliable composite manufacturing since the residual stresses alter the internal stress level of the composite part during the service life and the residual shape distortions may lead to not meeting the desired geometrical tolerances. The occurrence of residual stresses during the manufacturing process inherently contains diverse interactions between the involved physical phenomena mainly related to material flow, heat transfer and polymerization or crystallization. Development of numerical process models is required for virtual design and optimization of the composite manufacturing process which avoids the expensive trial-and-error based approaches. The process models as well as applications focusing on the prediction of residual stresses and shape distortions taking place in composite manufacturing are discussed in this study. The applications on both thermoset and thermoplastic based composites are reviewed in detail

Finite element analysis of vibrations induced by propagating waves generated by tunnel blasting

10.1007/BF01019675Rock Mechanics and Rock Engineering21153-78RMRE