Peri-implant disease: What we know and what we need to know

Peri-implant disease is a serious problem that plagues today's dentistry, both in terms of therapy and epidemiology. With the expansion of the practice of implantology and an increasing number of implants placed annually, the frequency of peri-implant disease has greatly expanded. Its clinical manifestations, in the absence of a globally established classification, are peri-implant mucositis and peri-implantitis, the counterparts of gingivitis and periodontitis, respectively. However, many doubts remain about its features. Official diagnostic criteria, globally recognized by the dental community, have not yet been introduced. The latest studies using metagenomic methods are casting doubt on the assumption of microbial equivalence between periodontal and peri-implant crevices. Research on most of the features of periimplant disease remains at an early stage; moreover, there is not a commonly accepted treatment for it. In any case, although the evidence so far collected is limited, we need to be aware of the current state of the science regarding this topic to better understand and ultimately prevent this disease

A high power CMOS class-D amplifier for inductive-link medical transmitters

Powering of medical implants by inductive coupling is an effective technique, which avoids the use of bulky implanted batteries or transcutaneous wires. On the external unit side, class-D and class-E power amplifiers (PAs) are conventionally used thanks to their high efficiency at high frequencies. The initial specifications driving this work require the use of multiple independent stimulators, which imposes serious constraints on the area and functionality of the external unit. An integrated circuit class-D PA has been designed to provide both small area and enhanced functionality, the latter achieved by the addition of an on-chip phased-locked loop (PLL), a dead-time generator and a phase detector. The PA has been designed in a 0.18μm CMOS high-voltage process technology and occupies an area of 9.86 mm2. It works at frequencies up to 14 MHz and 30 V supply and efficiencies higher than 80% are obtained at 14 MHz. The PA is intended for a closed-loop transmitter system that optimises power delivery to medical implants

Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers

Funding: This work was supported by Portuguese Agency for Innovation (PT2020) through the projects (CENTRO-01-0145-FEDER-000014) and (POCI-01-0247-FEDER-017771). It was also supported by the project PAMI – Portuguese Additive Manufacturing Initiative (project nº22158 – SAICT- AAC nº 01/SAICT/2016) and also, by the CDRSP– ID/Multi/04044/2019, funded by the Portuguese Government through FCT/MCTES and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT - Foundation for Science and Technology (UID / Multi / 00709/2019).Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high encapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect, and high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal combination among the percentage of alginate and CaCl2, design of Experiments was applied. The obtained model presented to be statistically significant (p-value < 0.05), with a coefficient of determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling, and sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was successfully validated.info:eu-repo/semantics/publishedVersio

Additive Manufacturing Tools to Improve the Performance of Chromatographic Approaches

Chromatography is widely applied industrially. However, some limitations are associated with its common supports, and the impossibility to fully control their structural features is particularly restrictive. Additive manufacturing (AM) is emerging as a fast, highly precise, and reproducible technology for producing chromatographic supports that can improve its performance.info:eu-repo/semantics/publishedVersio

Water quality in the Municipality of São Domingos (Santiago island, Cape Verde)

O presente estudo tem como objetivo avaliar a qualidade da água e potencialidades de uso no concelho de São Domingos, na ilha de Santiago (Cabo Verde). Os resultados obtidos mostram, o carácter mineralizado destas águas, com valor médio de condutividade elétrica de 1361 µS/cm. A classificação hidroquímica, de acordo com o diagrama de Piper, conduziu à discriminação dos seguintes tipos: águas mistas (bicarbonatadas, cloretadas) e mistas sódicas (cloretadas e bicarbonatadas). Considerando o que está estabelecido na legislação Cabo-verdiana e Portuguesa relativamente à qualidade da água, verificouse que apenas 36 % das amostras têm qualidade suficiente para consumo humano. No que respeita à utilização da água para rega, cerca de 68 % das amostras apresentam evidências de risco de salinização alto a muito alto.This research aims the evaluation of water quality and potential uses at São Domingos municipality, at Santiago Island (Cape Verde). The results show the mineralized nature of these waters, with an average electrical conductivity of 1361 μS/cm. The hydrochemical classification, according to the Piper diagram, led to the following types: mixed (bicarbonate and chloride) and mixed with sodium (chloride and bicarbonate). Considering what is established for water quality in the Cape Verde and Portuguese legislation, only 36 % of the water samples are able for human consumption. Regarding irrigation use, approximately 68 % of the samples present high-to-very-high salinization risk.(undefined)info:eu-repo/semantics/publishedVersio

Correlation between magnetic interactions and domain structure in A1 FePt ferromagnetic thin films

We have investigated the relationship between the domain structure and the magnetic interactions in a series of FePt ferromagnetic thin films of varying thickness. As-made films grow in the magnetically soft and chemically disordered A1 phase that may have two distinct domain structures. Above a critical thickness $d_{cr}\sim 30$ nm the presence of an out of plane anisotropy induces the formation of stripes, while for $d<d_{cr}$ planar domains occur. Magnetic interactions have been characterized using the well known DCD-IRM remanence protocols, $\delta M$ plots, and magnetic viscosity measurements. We have observed a strong correlation between the domain configuration and the sign of the magnetic interactions. Planar domains are associated with positive exchange-like interactions, while stripe domains have a strong negative dipolar-like contribution. In this last case we have found a close correlation between the interaction parameter and the surface dipolar energy of the stripe domain structure. Using time dependent magnetic viscosity measurements, we have also estimated an average activation volume for magnetic reversal, $\langle V_{ac}\rangle \sim 1.37\times 10^{4}$ nm$^{3},$ which is approximately independent of the film thickness or the stripe period.Comment: 25 pages, 11 figure

Effects of fish removal in the Furnas Lake, Azores

The Furnas Lake is a small volcanic, monomitic and increasingly eutrophised water body. Next to agricultural nutrient inputs, high densities of herbivorous fish are thought to contribute to high levels of turbidity in the lake, through zooplankton consumption and re suspension of the nutrients accumulated in the sediment. According to the alternative state hypothesis a shift from turbid to clear water conditions is favoured by reduction of nutrient concentrations, increased light availability and reduction of planktivorous and benthos-feeding fish stock. To improve water quality in the Furnas Lake, a substantial part of the bottom-feeding fish population (62% of the estimated common carp population, Cyprinus carpio, and 5% of the estimated roach population, Rutilus rutilus) was removed. Effects of fish removal on turbidity and associated trophic state were analysed next to post-manipulation chlorophyll a concentration, zooplankton and macrophytes densities. Results suggest that fish removal was not enough to change lake conditions towards a lasting clear state dominated by macrophytes. Excessive nutrient load, in water and sediments, nutrient input from the lake basin and fish recruitment causing enhanced zooplankton grazing are appointed causes. Any further biomanipulation efforts should be associated to nutrient reduction; and continued monitoring of water quality, fish stock, macrophytes and zooplankton is needed

Pesca em águas interiores na ilha de S. Miguel (Açores)

XII congresso da Associação Espanhola de Limnologia/IV Congresso Ibérico de Limnologia, organizado pela Associação Espanhola de Limnologia, de 5 a 9 de Julho de 2004 no Porto, Portugal.A ilha de S. Miguel é dotada de lagoas e ribeiras abundantes em espécies piscícolas que levaram ao desenvolvimento da pesca desportiva. Todas as espécies existentes nas lagoas foram introduzidas por acção humana