Andegameryx andegaviensis Ginsburg, 1971 (Artiodactyla, Ruminantia,) del Mioceno inferior de Estrepouy (MN3, Francia)

Several dental remains from the Early Miocene of Estrepouy (MN3, France) previously reported as Amphitragulus aurelianensis by Roman & Viret (1934) are described in this work and assigned to Andegameryx andegaviensis Ginsburg, 1971. The re-study of this material and the comparison with other remains of A. andegaviensis from several european localities of the early Miocene, including the type locality of the species, have permitted us to confirm the presence of A. andegaviensis in the ruminant fauna from Estrepouy.En esta nota describimos algunos de los restos del yacimiento del Mioceno inferior de Estrepouy (MN3, Francia) atribuidos por Roman & Viret (1934) a Amphitragulus aruelianensis, cambiando su asignación a Andegameryx andegaviensis Ginsburg, 1971. El reestudio del material y su comparación con los restos de A. andegaviensis de otras localidades europeas del Mioceno inferior, incluyendo la localidad tipo de la especie, permiten confirmar su presencia entre la fauna de rumiantes fósiles de Estrepouy

Presencia del bóvido Austroportax en el yacimiento mioceno de Batallones-1 (MN 10, cuenca de Madrid, España)

Bovid fossils constitute rare findings in the Cerro de los Batallones fossil sites. However, maxillar and mandibular remains of a juvenile individual of a large-sized bovid were discovered in Batallones-1. In the present work, we describe these fossils and assign them to the Eurpoean genus Austroportax (Sickenberg, 1829). We name these fossils as Austroportax sp. due to the lack of more diagnostic additional material belonging to this form.Los restos de bóvidos son excepcionalmente raros en los yacimientos del Cerro de los Batallones. Sin embargo, en Batallones-1 se han hallado restos mandibulares y maxilares de un individuo juvenil perteneciente a una especie de bóvido de talla grande. En el presente trabajo describimos estos fósiles y los asignamos al género europeo Austroportax (Sickenberg, 1829). Los fósiles quedan nombrados como Austroportax sp. debido a la ausencia de material diagnóstico adicional perteneciente a esta especie

Nuevos datos sobre Andegameryx (Mammalia, Ruminantia) del Mioceno Inferior de las Bardenas Reales (Navarra, España)

New fossil remains of ruminants from the Lower Miocene (Ramblian, MN3) of the Bardenas Reales (Navarre) are studied in this paper. The material, which comprises dentition, is assigned to Andegameryx aff. andegaviensis Ginsburg, 1971. Morphological and metrical similarities exist between these remains and the Spanish population of Andegameryx andegaviensis from Cetina de Aragón (Zaragoza), which is somewhat larger than the French material of this species. However, there are also some affinities with Andegameryx fossils from other Spanish localities as Loranca del Campo (Cuenca). The new material from the Bardenas Reales allows us to confirm certainly the presence of Andegameryx in the area and to provide the evidence that it was a widespread genus of ruminant in Spain during the early Miocene.En este trabajo se describen los nuevos hallazgos de rumiantes fósiles del Mioceno inferior (Rambliense, MN3) de las Bardenas Reales (Navarra). Este material está compuesto por dentición y ha sido clasificado como Andegameryx aff. andegaviensis Ginsburg, 1971. El estudio morfológico y métrico muestra que los restos de las Bardenas son muy semejantes a los de la población española de Andegameryx andegaviensis de Cetina de Aragón (Zaragoza), de talla algo mayor que las poblaciones francesas de esta especie. Sin embargo, también tiene afinidades con material de Andegameryx procedente de otras localidades españolas como Loranca del Campo (Cuenca). Los nuevos hallazgos permiten confirmar sin dudas la presencia de Andegameryx en las Bardenas Reales (Cuenca del Ebro), poniendo de manifiesto que este género de rumiante estuvo ampliamente extendido en las cuencas interiores de España durante el Mioceno inferior

Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature

Adverse events triggered by non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1. Coxibs, preferentially inhibiting cyclooxygenase-2, may therefore represent safe alternatives in patients with NSAID intolerance. We reviewed the literature in a systematic and structured manner to identify and evaluate studies on the tolerance of coxibs in patients with NSAID intolerance. We searched MEDLINE (1966–2006), the COCHRANE LIBRARY (4th Issue 2006) and EMBASE (1966–2006) up to December 9, 2006, and analysed all publications included using a predefined evaluation sheet. Symptoms and severity of adverse events to coxibs were analysed based on all articles comprising such information. Subsequently, the probability for adverse events triggered by coxibs was determined on analyses of double-blind prospective trials only. Among 3,304 patients with NSAID intolerance, 119 adverse events occurred under coxib medication. All adverse events, except two, have been allergic/urticarial in nature; none was lethal, but two were graded as life-threatening (grade 4). The two non-allergic adverse events were described as a grade 1 upper respiratory tract haemorrhage, and a grade 1 gastrointestinal symptom, respectively. In 13 double-blind prospective studies comprising a total of 591 patients with NSAID intolerance, only 13 adverse reactions to coxib provocations were observed. The triggering coxibs were rofecoxib (2/286), celecoxib (6/208), etoricoxib (4/56), and valdecoxib (1/41). This review documents the good tolerability of coxibs in patients with NSAID intolerance, for whom access to this class of drugs for short-term treatment of pain and inflammation is advantageous

A new Late Agenian (MN2a, Early Miocene) fossil assemblage from Wallenried (Molasse Basin, Canton Fribourg, Switzerland)

Excavations of two fossiliferous layers in the Wallenried sand- and marl pit produced a very diversified vertebrate fauna. New material allows the reassessment of the taxonomic position of the ruminant taxa Andegameryx andegaviensis and endemic Friburgomeryx wallenriedensis. An emended diagnosis for the second species is provided and additional material of large and small mammals, as well as ectothermic vertebrates, is described. The recorded Lagomorpha show interesting morphological deviations from other Central European material, and probably represent a unique transitional assemblage with a co-occurrence of Titanomys, Lagopsis and Prolagus. Rodentia and Eulipotyphla belong to typical and well-known species of the Agenian of the Swiss Molasse Basin. Abundant small mammal teeth have allowed us to pinpoint the biostratigraphic age of Wallenried to late MN2a. The biostratigraphic age conforms to data derived from the charophyte assemblages and confirms the oldest occurrence of venomous snake fangs. The palaeoenvironmental context is quite complex. Sedimentary structures and fauna (fishes, frogs, salamanders, ostracods) are characteristic for a humid, lacustrine environment within a flood plain system

Los Rumiantes (Artiodactyla, Mammalia) del Mioceno inferior de La Encinilla (Colmenar Viejo, Madrid)

This article is a preliminary study of the fossil ruminants found in the Early Miocene site of La Encinilla (Colmenar Viejo, Madrid). The morphological description of dentition and postcranial bones, along with the metrical and comparative study with material from localities of similar age in France and Spain has allowed us to confirm the presence of two Pecoran ruminants in La Encinilla: Andegameryx sp. and a larger species related to Teruelia Moy&#225;-Sol&#225;, 1987. Although the identification in one of the cases should be confirmed with more material, the record in the Madrid Bassin would represent new information regarding the known biogeographical distribution of both taxa. The systematic position of Andegameryx and Teruelia is still under discussion, but both forms are clearly distinct from the Cervoidea ruminants found in Europe and the Iberian Peninsula at the same age, such as Amphitragulus, Oriomeryx, Bedenomeryx or Dremotherium.<br><br>Este trabajo constituye un estudio preliminar de los restos de rumiantes f&#243;siles hallados en el yacimiento del Mioceno inferior de La Encinilla (Colmenar Viejo, Madrid). La descripci&#243;n morfol&#243;gica de la dentici&#243;n y del esqueleto postcraneal, as&#237; como el estudio m&#233;trico y comparativo con material procedente de localidades francesas y espa&#241;olas de edad similar ha permitido constatar hasta el momento la presencia de dos formas de rumiantes Pecora en La Encinilla: Andegameryx sp. y un rumiante de mayor talla relacionado con Teruelia Moy&#225;-Sol&#225;, 1987. Aunque la identificaci&#243;n en uno de los casos necesitar&#237;a confirmarse con m&#225;s material, la presencia de estas dos formas en la Cuenca de Madrid ampliar&#237;a la distribuci&#243;n biogeogr&#225;fica conocida para ambos taxones. La posici&#243;n sistem&#225;tica de Andegameryx y Teruelia permanece abierta a discusi&#243;n, pero ambos g&#233;neros se diferencian de los Cervoidea del Mioceno inferior encontrados en Europa y la Pen&#237;nsula Ib&#233;rica, tales como Amphitragulus, Oriomeryx, Bedenomeryx o Dremotherium

New fossils of the early Miocene stem-cervid Acteocemas (Artiodactyla, Ruminantia) from the Iberian Peninsula shed light on the evolutionary origin of deer antler regeneration

Acteocemas, a very poorly documented early Miocene stem-cervid, is one of the first ruminants bearing antler-like appendages, which has provided a ground for discussion on the origin of antlers. We describe a new and very complete appendage from the site of Sant Andreu de la Barca (Spain) together with some other unpublished specimens from the nearby Costablanca attributed to Acteocemas aff. infans, compare with fossils from elsewhere in Europe (including the A. infans holotype), and perform micro-CT scans. The findings provide new empirical data that Acteocemas protoantlers were able to be cast and re-grown. However, microstructural analyses suggest that the protoantler lifespan could be longer than that of modern antlers, preventing it from assuming a similar cycle. Results support that increased seasonality associated with a drop in global temperatures played a role in the origin of antler regeneration, and that deciduousness (through bone shedding) was an efficient way for (male)deer to reduce the seasonal leftover of bone mass. The early evolution of deciduousness, as in the probable irregular protoanter cycle of Acteocemas, was limited by the warming ca. 17–15 Ma, whereas the emergence of antlers with coronet was concomitant with the second increase in seasonality associated to the cooling ca. 15–13 Ma