13,760 research outputs found
Surface mixing and biological activity in the four Eastern Boundary Upwelling Systems
Eastern Boundary Upwelling Systems (EBUS) are characterized by a high
productivity of plankton associated with large commercial fisheries, thus
playing key biological and socio-economical roles. The aim of this work is to
make a comparative study of these four upwelling systems focussing on their
surface stirring, using the Finite Size Lyapunov Exponents (FSLEs), and their
biological activity, based on satellite data. First, the spatial distribution
of horizontal mixing is analysed from time averages and from probability
density functions of FSLEs. Then we studied the temporal variability of surface
stirring focussing on the annual and seasonal cycle. There is a global negative
correlation between surface horizontal mixing and chlorophyll standing stocks
over the four areas. To try to better understand this inverse relationship, we
consider the vertical dimension by looking at the Ekman-transport and vertical
velocities. We suggest the possibility of a changing response of the
phytoplankton to sub/mesoscale turbulence, from a negative effect in the very
productive coastal areas to a positive one in the open ocean.Comment: 12 pages. NPG Special Issue on "Nonlinear processes in oceanic and
atmospheric flows". Open Access paper, available also at the publisher site:
http://www.nonlin-processes-geophys.net/16/557/2009
Temperature dependent dynamic and static magnetic response in magnetic tunnel junctions with Permalloy layers
Ferromagnetic resonance and static magnetic properties of CoFe/Al2O3/CoFe/Py
and CoFe/Al2O3/CoFeB/Py magnetic tunnel junctions and of 25nm thick
single-layer Permalloy(Py) films have been studied as a function of temperature
down to 2K. The temperature dependence of the ferromagnetic resonance excited
in the Py layers in magnetic tunnel junctions shows knee-like enhancement of
the resonance frequency accompanied by an anomaly in the magnetization near
60K. We attribute the anomalous static and dynamic magnetic response at low
temperatures to interface stress induced magnetic reorientation transition at
the Py interface which could be influenced by dipolar soft-hard layer coupling
through the Al2O3 barrier
Clone size distributions in networks of genetic similarity
We build networks of genetic similarity in which the nodes are organisms
sampled from biological populations. The procedure is illustrated by
constructing networks from genetic data of a marine clonal plant. An important
feature in the networks is the presence of clone subgraphs, i.e. sets of
organisms with identical genotype forming clones. As a first step to understand
the dynamics that has shaped these networks, we point up a relationship between
a particular degree distribution and the clone size distribution in the
populations. We construct a dynamical model for the population dynamics,
focussing on the dynamics of the clones, and solve it for the required
distributions. Scale free and exponentially decaying forms are obtained
depending on parameter values, the first type being obtained when clonal growth
is the dominant process. Average distributions are dominated by the power law
behavior presented by the fastest replicating populations.Comment: 17 pages, 4 figures. One figure improved and other minor changes. To
appear in Physica
Rubidium and zirconium abundances in massive Galactic asymptotic giant branch stars revisited
Luminous Galactic OH/IR stars have been identified as massive (>4-5 M_s) AGB
stars experiencing HBB and Li production. Their Rb abundances and [Rb/Zr]
ratios derived from hydrostatic model atmospheres, are significantly higher
than predictions from AGB nucleosynthesis models, posing a problem to our
understanding of AGB evolution and nucleosynthesis. We report new Rb and Zr
abundances in the full sample of massive Galactic AGB stars, previously studied
with hydrostatic models, by using more realistic extended model atmospheres. We
use a modified version of the spectral synthesis code Turbospectrum and
consider the presence of a circumstellar envelope and radial wind. The Rb and
Zr abundances are determined from the 7800 A Rb I resonant line and the 6474 A
ZrO bandhead, respectively, and we explore the sensitivity of the derived
abundances to variations of the stellar (Teff) and wind (M_loss, beta and vexp)
parameters in the extended models. The Rb and Zr abundances derived from the
best spectral fits are compared with the most recent AGB nucleosynthesis
theoretical models. The new Rb abundances are much lower (even 1-2 dex) than
those derived with the hydrostatic models, while the Zr abundances are similar.
The Rb I line profile and Rb abundance are very sensitive to the M_loss rate
but much less sensitive to variations of the wind velocity-law and the
vexp(OH). We confirm the earlier preliminary results based on a smaller sample
of massive O-rich AGB stars, that the use of extended atmosphere models can
solve the discrepancy between the AGB nucleosynthesis theoretical models and
the observations of Galactic massive AGB stars. The Rb abundances, however, are
still strongly dependent of the M_loss, which is unknown in these AGB stars.
Accurate M_loss rates in these massive Galactic AGB stars are needed in order
to break the models degeneracy and get reliable Rb abundances in these stars.Comment: Accepted for publication in A&A, 14 pages, 12 figures, 4 table
The relationship between sleep quality and all-cause, CVD and cancer mortality: the Southall and Brent REvisited study (SABRE)
Background: Both long and short sleep duration increase risk of mortality. Most previous studies have been performed in Europeans and have focused on sleep duration. Thus, we aimed to investigate the association between sleep quality and mortality across three different ethnic groups. / Methods: We used data from the Southall and Brent REvisited Study (SABRE) cohort, which comprises first generation migrant South Asian and African Caribbean men and women, aged 40–69 years, recruited between 1988 and 1991. In sum, 4399 participants provided complete data at baseline and follow-up. Of those, 1656 died by December 2017. Our exposures (eg, difficulty falling asleep, early morning waking and waking up tired in the morning) were self-reported and our primary outcome was mortality. We used Cox proportional hazards models to analyse our data, adjusting for baseline-measured confounders. / Results: None of the sleep measures were strongly associated with all-cause mortality in Europeans or African Caribbeans, whilst in South Asians difficulty falling asleep was related to an increased risk of all-cause mortality (HR = 1.28, 95%CI = 1.01; 1.61). In Europeans, early morning waking was associated with a moderately increased risk of cardiovascular death (HR = 1.31, 95%CI = 1.05; 1.63); alternately, this association was not as strong in the other groups. / Conclusion: Our findings suggest that the relationship between sleep quality and mortality may differ by ethnic group, but formal heterogeneity tests indicated that the strongest difference in HRs was observed for early morning waking and cardiovascular disease (CVD) mortality across the three groups (Cochran's Q test p = 0.036). As such, these results are novel and provide support for ethnic differences in sleep quality and mortality, and may have implications for precision medicine
Evolutionary and Ecological Trees and Networks
Evolutionary relationships between species are usually represented in
phylogenies, i.e. evolutionary trees, which are a type of networks. The
terminal nodes of these trees represent species, which are made of individuals
and populations among which gene flow occurs. This flow can also be represented
as a network. In this paper we briefly show some properties of these complex
networks of evolutionary and ecological relationships. First, we characterize
large scale evolutionary relationships in the Tree of Life by a degree
distribution. Second, we represent genetic relationships between individuals of
a Mediterranean marine plant, Posidonia oceanica, in terms of a Minimum
Spanning Tree. Finally, relationships among plant shoots inside populations are
represented as networks of genetic similarity.Comment: 6 pages, 5 figures. To appear in Proceedings of the Medyfinol06
Conferenc
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an active metabolite of vitamin A, restores mechanical quiescence in PSCs via a mechanism involving a retinoic acid receptor beta (RAR-β)-dependent downregulation of actomyosin (MLC-2) contractility. We show that ATRA reduces the ability of PSCs to generate high traction forces and adapt to extracellular mechanical cues (mechanosensing), as well as suppresses force-mediated extracellular matrix remodelling to inhibit local cancer cell invasion in 3D organotypic models. Our findings implicate a RAR-β/MLC-2 pathway in peritumoural stromal remodelling and mechanosensory-driven activation of PSCs, and further suggest that mechanical reprogramming of PSCs with retinoic acid derivatives might be a viable alternative to stromal ablation strategies for the treatment of PDAC
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