Image Automatic Categorisation using Selected Features Attained from Integrated Non-Subsampled Contourlet with Multiphase Level Sets

A framework of automatic detection and categorization of Breast Cancer (BC) biopsy images utilizing significant interpretable features is initially considered in discussed work. Appropriate efficient techniques are engaged in layout steps of the discussed framework. Different steps include 1.To emphasize the edge particulars of tissue structure; the distinguished Non-Subsampled Contourlet (NSC) transform is implemented. 2. For the demarcation of cells from background, k-means, Adaptive Size Marker Controlled Watershed, two proposed integrated methodologies were discussed. Proposed Method-II, an integrated approach of NSC and Multiphase Level Sets is preferred to other segmentation practices as it proves better performance 3. In feature extraction phase, extracted 13 shape morphology, 33 textural (includes 6 histogram, 22 Haralick’s, 3 Tamura’s, 2 Graylevel Run-Length Matrix,) and 2 intensity features from partitioned tissue images for 96 trained image

Evaluation Of The Complications Associated With ORIF In The Management Of Mandibular Fractures- A 7 Years Retrospective Study

Aim: This study is intended to evaluate the incidence of post-operative complications associated with ORIF in the management of mandibular fracturesMaterials and Method: A total of 224 patients who were diagnosed clinically and radiographically to have sustained mandibular fractures and were managed with ORIF between the period of June 2012 to May 2019 were included. Patient’s records were analysed to evaluate the incidence of post-operative complications that are associated with ORIF in the management of mandibular fractures.Results: It was observed that patients who underwent ORIF for the management of condylar fractures reported with relatively higher number of complications when compared to mandibular angle / body / parasymphysis fractures. Wound dehiscence, occlusal disturbance, paresthesia and infection leading to the removal of miniplates in general are the notable complications following ORIF.Conclusion: It can be concluded that the most common complications associated with ORIF in the management of mandibular fractures were majorly due to the surgical approach used than the type of fixation devices/techniques

Read what you need: Controllable Aspect-based Opinion Summarization of Tourist Reviews

Manually extracting relevant aspects and opinions from large volumes of user-generated text is a time-consuming process. Summaries, on the other hand, help readers with limited time budgets to quickly consume the key ideas from the data. State-of-the-art approaches for multi-document summarization, however, do not consider user preferences while generating summaries. In this work, we argue the need and propose a solution for generating personalized aspect-based opinion summaries from large collections of online tourist reviews. We let our readers decide and control several attributes of the summary such as the length and specific aspects of interest among others. Specifically, we take an unsupervised approach to extract coherent aspects from tourist reviews posted on TripAdvisor. We then propose an Integer Linear Programming (ILP) based extractive technique to select an informative subset of opinions around the identified aspects while respecting the user-specified values for various control parameters. Finally, we evaluate and compare our summaries using crowdsourcing and ROUGE-based metrics and obtain competitive results.Comment: 4 pages, accepted in the Proceedings of the 43rd International ACM SIGIR Conference on Research and Development in Information Retrieval (SIGIR), 202

A double-blind randomized placebo-controlled study of low dose mirtazapine once daily in patients of major depressive disorders on escitalopram

Background: The SSRIs being used as 1st line therapy in treatment of depression have delayed therapeutic effect which makes the patient vulnerable to an increased risk of suicide and decreased adherence to the treatment and will prematurely discontinue the therapy. The present study was conducted to evaluate if low dose mirtazapine-escitalopram combination therapy has any add on benefit over monotherapy with escitalopram.Methods: In a single-centered, comparative study involving patients with depression attending the out-patient after screening and exclusion, 60 eligible patients were randomly assigned to receive tablet mirtazapine 7.5 mg plus tablet escitalopram 10 mg intervention or tablet escitalopram 10 mg plus placebo intervention in a double-blind 6-week treatment phase. The primary outcome measure was the change in the 17-item Hamilton Depression Rating Scale (HDRS) and Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline. Participants were evaluated at baseline, 1st, 2nd,4th and 6th week. Results were analyzed using Chi-Square test for adverse effects and independent t-test analysis for efficacy parameter.Results: In the analysis of results at 6th week the numbers of patients achieved remission in mirtazapine group are more with a p-value of 0.018 which is significant and the numbers of responders in mirtazapine group are also more which is statistically significant on chi-square test. There is no significant difference was observed between the two groups with reference to occurrence of adverse effect.Conclusions: Adding low dose mirtazapine has an added benefit in terms of efficacy and getting remission early with more number of responders in the treatment of major depression

Design of a Protective Single-Dose Intranasal Nanoparticle-Based Vaccine Platform for Respiratory Infectious Diseases

Despite the successes provided by vaccination, many challenges still exist with respect to controlling new and re-emerging infectious diseases. Innovative vaccine platforms composed of adaptable adjuvants able to appropriately modulate immune responses, induce long-lived immunity in a single dose, and deliver immunogens in a safe and stable manner via multiple routes of administration are needed. This work describes the development of a novel biodegradable polyanhydride nanoparticle-based vaccine platform administered as a single intranasal dose that induced long-lived protective immunity against respiratory disease caused by Yesinia pestis, the causative agent of pneumonic plague. Relative to the responses induced by the recombinant protein F1-V alone and MPLA-adjuvanted F1-V, the nanoparticle-based vaccination regimen induced an immune response that was characterized by high titer and high avidity IgG1 anti-F1-V antibody that persisted for at least 23 weeks post-vaccination. After challenge, no Y. pestis were recovered from the lungs, livers, or spleens of mice vaccinated with the nanoparticle-based formulation and histopathological appearance of lung, liver, and splenic tissues from these mice post-vaccination was remarkably similar to uninfected control mice

Comparative analyses on medium optimization using one-factor-at-a-time, response surface methodology, and artificial neural network for lysine–methionine biosynthesis by Pediococcus pentosaceus RF-1

Optimization strategy that encompassed one-factor-at-a-time (OFAT), response surface methodology (RSM), and artificial neural network method was implemented during medium formulation with specific aim for lysine-methionine biosynthesis employing a newly isolated strain of Pediococcus pentosaceus RF-1. OFAT technique was used in the preliminary screening of factors (molasses, nitrogen sources, fish meal, glutamic acid and initial medium pH) before proceeded to optimization study. Implementation of central composite design of experiment subsequently generated 30 experimental runs based on four factors (molasses, fish meal, glutamic acid, and initial medium pH). From RSM analysis, a quadratic polynomial model can be devoted to describing the relationship between various medium components and responses. It also suggested that using molasses (9.86 g/L), fish meal (10.06 g/L), glutamic acid (0.91 g/L), and initial medium pH (5.30) would enhance the biosynthesis of lysine (15.77 g/L) and methionine (4.21 g/L). Alternatively, a three-layer neural network topography at 4-5-2 predicted a further improvement in the biosynthesis of lysine (16.52 g/L) and methionine (4.53 g/L) by using formulation composed of molasses (10.02 g/L), fish meal (18.00 g/L), and glutamic acid (1.17 g/L) with initial medium pH (4.26), respectively

Adenoid cystic carcinoma mimicking benign mucosal cyst of maxillary sinus

Adenoid cystic carcinoma (ACC) is an infrequent neoplasm arising in minor salivary glands and contiguous tissues in the head and neck region. It is further communal in the minor salivary glands (>25%) fairly than in the major salivary glands (about 5%). ACC has distinctive histologic features, with cribriform and tubular growth patterns of basaloid cells revealing principally a myoepithelial cellular phenotype. The clinical and pathological findings emblematic of this tumor include slow growth, perineural invasion, and impending local recurrence. This report presents a solitary lesion of the left maxilla which mimicked a benign mucosal cyst of the maxillary sinus. Initial clinical presentation and investigations were misleading while the microscopic examination of the excised lesion revealed an ACC

Understanding the Molecular Basis for the Nucleotide-Binding Oligomerization Domain-Containing Protein 2-Mediated Regulation of 5-Lipoxygenase

Inflammation is important in mediating host defense. However, chronic inflammation can lead to the development of numerous lifelong disorders. Specialized pro-resolving lipid mediators (SPMs) are lipid mediators that actively inhibit inflammation and enhance resolution. SPMs are generated through the actions of various lipid mediator biosynthetic enzymes such as 5-lipoxygenase (5LO or ALOX5). While there has been a lot of progress elucidating lipoxygenase- mediated biosynthetic pathways leading to SPM production, the upstream cues governing activation and regulation of ALOX5 are still not fully understood. Our laboratory discovered that engagement of the NOD2 pathway led to the production of not only pro-inflammatory lipid mediators, but also SPMs. In order to understand how NOD2 was mediating these effects, we investigated the role of NOD2 in influencing the post-translational modification, localization, and stabilization of ALOX5. We found that while the presence of NOD2 promoted the activating phosphorylation of ALOX5, it also decreased the levels of ALOX5 in a dose-dependent manner. Further pulse-chase analysis indicated that although NOD2 initially decreased ALOX5 protein levels, it ultimately prolonged the half-life of total and phosphorylated ALOX5. It was also observed that certain disease associated NOD2 variants caused dysregulated phosphorylation of ALOX5 or dysregulated localization of activated ALOX5. Lastly, mass spectrometry analysis of ALOX5 in M1 or M2 polarized THP-1 macrophages stimulated with the NOD2 agonist MDP indicated differential proline hydroxylation of ALOX5 under these conditions. Understanding how NOD2 influences ALOX5 may shed light on the mechanisms which are dysregulated under pathological conditions and could inform the potential utility of various inhibitors of lipid mediator production or of NOD2/RIP2 signaling for treatment of specific inflammatory diseases