Redundant dataflow applications on clustered manycore architectures

Increasing performance requirements in the embedded systems domain have encouraged a drift from singlecore to multicore processors. Cars are an example for complex embedded systems in which the use of multicores continues to grow. The requirements of software components running in modern cars are diverse. On the one hand there are safety-critical tasks like the airbag control, on the other hand tasks which do not have any safety-related requirements at all, for example those controlling the infotainment system. Trends like autonomous driving lead to tasks which are simultaneously safety-critical and computationally complex. To satisfy the requirements of modern embedded applications we developed a dataflow-based runtime environment (RTE) for clustered manycore architectures. The RTE is able to execute dataflow graphs in various redundancy configurations and with different schedulers. We implemented our RTE design on the Kalray Bostan Massively Parallel Processor Array and evaluated all possible configurations for three common computation tasks. To classify the performance of our RTE, we compared the non-redundant graph executions with OpenCL versions of the three applications. The results show that our RTE can come close or even surpass Kalray's OpenCL framework, although maximum performance was not the primary goal of our design

Software Startups -- A Research Agenda

Software startup companies develop innovative, software-intensive products within limited time frames and with few resources, searching for sustainable and scalable business models. Software startups are quite distinct from traditional mature software companies, but also from micro-, small-, and medium-sized enterprises, introducing new challenges relevant for software engineering research. This paper's research agenda focuses on software engineering in startups, identifying, in particular, 70+ research questions in the areas of supporting startup engineering activities, startup evolution models and patterns, ecosystems and innovation hubs, human aspects in software startups, applying startup concepts in non-startup environments, and methodologies and theories for startup research. We connect and motivate this research agenda with past studies in software startup research, while pointing out possible future directions. While all authors of this research agenda have their main background in Software Engineering or Computer Science, their interest in software startups broadens the perspective to the challenges, but also to the opportunities that emerge from multi-disciplinary research. Our audience is therefore primarily software engineering researchers, even though we aim at stimulating collaborations and research that crosses disciplinary boundaries. We believe that with this research agenda we cover a wide spectrum of the software startup industry current needs

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs

© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The article attached is the publisher's pdf

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms

Through various pathways of cell death, degradation, and regulated extrusion, partial or complete genomes of various origins (e.g., host cells, fetal cells, and infiltrating viruses and microbes) are continuously shed into human body fluids in the form of segmented cell-free DNA (cfDNA) molecules. While the genetic complexity of total cfDNA is vast, the development of progressively efficient extraction, high-throughput sequencing, characterization via bioinformatics procedures, and detection have resulted in increasingly accurate partitioning and profiling of cfDNA subtypes. Not surprisingly, cfDNA analysis is emerging as a powerful clinical tool in many branches of medicine. In addition, the low invasiveness of longitudinal cfDNA sampling provides unprecedented access to study temporal genomic changes in a variety of contexts. However, the genetic diversity of cfDNA is also a great source of ambiguity and poses significant experimental and analytical challenges. For example, the cfDNA population in the bloodstream is heterogeneous and also fluctuates dynamically, differs between individuals, and exhibits numerous overlapping features despite often originating from different sources and processes. Therefore, a deeper understanding of the determining variables that impact the properties of cfDNA is crucial, however, thus far, is largely lacking. In this work we review recent and historical research on active vs. passive release mechanisms and estimate the significance and extent of their contribution to the composition of cfDNA

Less invasive off-pump implantation of axial flow pumps in chronic ischemic heart failure: Survival effects

Off-pump implantation of left ventricular assist device (LVAD) axial or centrifugal flow pumps in patients with low ejection fraction (EF) is of major clinical relevance. In addition, all pre-clinical, long-term implantations performed so far have been carried out in healthy animals, but this does not reflect the eventual clinical setting. In this study we established a new technique using a miniaturized axial flow pump in sheep with chronically ischemic myocardium. Sheep ( n = 15) underwent intracoronary sphere injection to create chronic ischemic heart failure. Reduced EF was assessed using transesophageal echocardiography. All animals underwent implantation of a new miniaturized axial flow pump via an extraperitoneal, subcostal surgical approach. Our technique allows easy exposure of the diaphragmatic surface of the heart and the descending aorta. Ten animals (range 65 to 78 kg) underwent off-pump implantation 30 (range 25 to 33) days after intracoronary sphere injection. All animals had significantly reduced EF (25 ± 4.8%) and were receiving high doses of inotropic agents to maintain cardiac function. Nine animals survived the surgical procedure. The average 12-hour blood loss was 435 ml. Cardiac index improved significantly in all animals. The procedure time was not extended by any adverse events (60 to 145 minutes). The extraperitoneal, subcostal surgical approach is less invasive than a median sternotomy and allows centrifugal or axial to be implanted quickly and without cardiopulmonary bypass (CPB). Avoiding CPB and an extensive mediastinal dissection can help to decrease significantly the number of complications in patients with end-stage organ failure

Positron Emission Tomography/Computed Tomographic and Magnetic Resonance Imaging in a Murine Model of Progressive Atherosclerosis Using ⁶⁴Cu-Labeled Glycoprotein VI-Fc

Background— Plaque erosion leads to exposure of subendothelial collagen, which may be targeted by glycoprotein VI (GPVI). We aimed to detect plaque erosion using 64 Cu-labeled GPVI-Fc (fragment crystallized). Methods and Results— Four-week-old male apolipoprotein E–deficient (ApoE −/− ) mice (n=6) were fed a high-fat diet for 12 weeks. C57BL/6J wild-type (WT) mice served as controls (n=6). Another group of WT mice received a ligation injury of the left carotid artery (n=6) or sham procedure (n=4). All mice received a total activity of ≈12 MBq 64 Cu-GPVI-Fc by tail vein injection followed by delayed (24 hours) positron emission tomography using a NanoPET/computed tomographic scanner (Mediso, Hungary; Bioscan, USA) with an acquisition time of 1800 seconds. Seventy-two hours after positron emission tomography/computed tomography, all mice were scanned 2 hours after intravenous administration of 0.2 mmol/kg body weight of a gadolinium-based elastin-specific MR contrast agent. MRI was performed on a 3-T clinical scanner (Philips Healthcare, Best, The Netherlands). In ApoE −/− mice, the 64 Cu-GPVI-Fc uptake in the aortic arch was significantly higher compared with WT mice (ApoE −/− : 13.2±1.5 Bq/cm 3 versus WT mice: 5.1±0.5 Bq/cm 3 ; P =0.028). 64 Cu-GPVI-Fc uptake was also higher in the injured left carotid artery wall compared with the intact right carotid artery of WT mice and as a trend compared with sham procedure (injured: 20.7±1.3 Bq/cm 3 versus intact: 2.3±0.5 Bq/cm 3 ; P =0.028 versus sham: 12.7±1.7 Bq/cm 3 ; P =0.068). Results were confirmed by ex vivo histology and in vivo MRI with elastin-specific MR contrast agent that measures plaque burden and vessel wall remodeling. Higher R1 relaxation rates were found in the injured carotid wall with a T1 mapping sequence (injured: 1.44±0.08 s −1 versus intact: 0.91±0.02 s −1 ; P =0.028 versus sham: 0.97±0.05 s −1 ; P =0.068) and in the aortic arch of ApoE −/− mice compared with WT mice (ApoE −/− : 1.49±0.05 s −1 versus WT: 0.92±0.04 s −1 ; P =0.028). Conclusions— 64 Cu-GPVI-Fc positron emission tomographic imaging allows identification of exposed subendothelial collagen in injured WT and high-fat diet–fed ApoE −/− mice. </jats:sec