139 research outputs found
On the miscible Rayleigh-Taylor instability: two and three dimensions
We investigate the miscible Rayleigh-Taylor (RT) instability in both 2 and 3
dimensions using direct numerical simulations, where the working fluid is
assumed incompressible under the Boussinesq approximation. We first consider
the case of randomly perturbed interfaces. With a variety of diagnostics, we
develop a physical picture for the detailed temporal development of the mixed
layer: We identify three distinct evolutionary phases in the development of the
mixed layer, which can be related to detailed variations in the growth of the
mixing zone. Our analysis provides an explanation for the observed differences
between two and three-dimensional RT instability; the analysis also leads us to
concentrate on the RT models which (1) work equally well for both laminar and
turbulent flows, and (2) do not depend on turbulent scaling within the mixing
layer between fluids. These candidate RT models are based on point sources
within bubbles (or plumes) and interaction with each other (or the background
flow). With this motivation, we examine the evolution of single plumes, and
relate our numerical results (of single plumes) to a simple analytical model
for plume evolution.Comment: 31 pages, 27 figures, to appear in November issue of JFM, 2001. For
better figures: http://astro.uchicago.edu/~young/ps/jfmtry08.ps.
Simulations of Astrophysical Fluid Instabilities
We present direct numerical simulations of mixing at Rayleigh-Taylor unstable
interfaces performed with the FLASH code, developed at the ASCI/Alliances
Center for Astrophysical Thermonuclear Flashes at the University of Chicago. We
present initial results of single-mode studies in two and three dimensions. Our
results indicate that three-dimensional instabilities grow significantly faster
than two-dimensional instabilities and that grid resolution can have a
significant effect on instability growth rates. We also find that unphysical
diffusive mixing occurs at the fluid interface, particularly in poorly resolved
simulations.Comment: 3 pages, 1 figure. To appear in the proceedings of the 20th Texas
Symposium on Relativistic Astrophysic
Optimal, scalable forward models for computing gravity anomalies
We describe three approaches for computing a gravity signal from a density
anomaly. The first approach consists of the classical "summation" technique,
whilst the remaining two methods solve the Poisson problem for the
gravitational potential using either a Finite Element (FE) discretization
employing a multilevel preconditioner, or a Green's function evaluated with the
Fast Multipole Method (FMM). The methods utilizing the PDE formulation
described here differ from previously published approaches used in gravity
modeling in that they are optimal, implying that both the memory and
computational time required scale linearly with respect to the number of
unknowns in the potential field. Additionally, all of the implementations
presented here are developed such that the computations can be performed in a
massively parallel, distributed memory computing environment. Through numerical
experiments, we compare the methods on the basis of their discretization error,
CPU time and parallel scalability. We demonstrate the parallel scalability of
all these techniques by running forward models with up to voxels on
1000's of cores.Comment: 38 pages, 13 figures; accepted by Geophysical Journal Internationa
Large-Scale Simulations of Clusters of Galaxies
We discuss some of the computational challenges encountered in simulating the
evolution of clusters of galaxies. Eulerian adaptive mesh refinement (AMR)
techniques can successfully address these challenges but are currently being
used by only a few groups. We describe our publicly available AMR code, FLASH,
which uses an object-oriented framework to manage its AMR library, physics
modules, and automated verification. We outline the development of the FLASH
framework to include collisionless particles, permitting it to be used for
cluster simulation.Comment: 3 pages, 3 figures, to appear in Proceedings of the VII International
Workshop on Advanced Computing and Analysis Techniques in Physics Research
(ACAT 2000), Fermilab, Oct. 16-20, 200
Risk Prediction in Acute Calculous Cholecystitis: A Systematic Review and Meta-analysis of Prognostic Factors and Predictive Models
BACKGROUND: Laparoscopic cholecystectomy is the main treatment of acute cholecystitis. Although considered relatively safe, it carries 6%–9% risk of major complications and 0.1%–1% risk of mortality. There is no consensus regarding the evaluation of the preoperative risks, and the management of patients with acute cholecystitis is usually guided by surgeon's personal preferences. We assessed the best method to identify patients with acute cholecystitis who are at high risk of complications and mortality. METHODS: We performed a systematic review of studies that reported the preoperative prediction of outcomes in people with acute cholecystitis. We searched the Cochrane Library, MEDLINE, EMBASE, WHO ICTRP, ClinicalTrials.gov, and Science Citation Index Expanded until April 27, 2019. We performed a meta-analysis when possible. RESULTS: Six thousand eight hundred twenty-seven people were included in one or more analyses in 12 studies. Tokyo guidelines 2013 (TG13) predicted mortality (two studies; Grade 3 versus Grade 1: odds ratio [OR] 5.08, 95% confidence interval [CI] 2.79–9.26). Gender predicted conversion to open cholecystectomy (two studies; OR 1.59, 95% CI 1.06–2.39). None of the factors reported in at least two studies had significant predictive ability of major or minor complications. CONCLUSION: There is significant uncertainty in the ability of prognostic factors and risk prediction models in predicting outcomes in people with acute calculous cholecystitis. Based on studies of high risk of bias, TG13 Grade 3 severity may be associated with greater mortality than Grade 1. Early referral of such patients to high-volume specialist centers should be considered. Further well-designed prospective studies are necessary
Brain Bases of Reading Fluency in Typical Reading and Impaired Fluency in Dyslexia
Although the neural systems supporting single word reading are well studied, there are limited direct comparisons between typical and dyslexic readers of the neural correlates of reading fluency. Reading fluency deficits are a persistent behavioral marker of dyslexia into adulthood. The current study identified the neural correlates of fluent reading in typical and dyslexic adult readers, using sentences presented in a word-by-word format in which single words were presented sequentially at fixed rates. Sentences were presented at slow, medium, and fast rates, and participants were asked to decide whether each sentence did or did not make sense semantically. As presentation rates increased, participants became less accurate and slower at making judgments, with comprehension accuracy decreasing disproportionately for dyslexic readers. In-scanner performance on the sentence task correlated significantly with standardized clinical measures of both reading fluency and phonological awareness. Both typical readers and readers with dyslexia exhibited widespread, bilateral increases in activation that corresponded to increases in presentation rate. Typical readers exhibited significantly larger gains in activation as a function of faster presentation rates than readers with dyslexia in several areas, including left prefrontal and left superior temporal regions associated with semantic retrieval and semantic and phonological representations. Group differences were more extensive when behavioral differences between conditions were equated across groups. These findings suggest a brain basis for impaired reading fluency in dyslexia, specifically a failure of brain regions involved in semantic retrieval and semantic and phonological representations to become fully engaged for comprehension at rapid reading rates
On Validating an Astrophysical Simulation Code
We present a case study of validating an astrophysical simulation code. Our
study focuses on validating FLASH, a parallel, adaptive-mesh hydrodynamics code
for studying the compressible, reactive flows found in many astrophysical
environments. We describe the astrophysics problems of interest and the
challenges associated with simulating these problems. We describe methodology
and discuss solutions to difficulties encountered in verification and
validation. We describe verification tests regularly administered to the code,
present the results of new verification tests, and outline a method for testing
general equations of state. We present the results of two validation tests in
which we compared simulations to experimental data. The first is of a
laser-driven shock propagating through a multi-layer target, a configuration
subject to both Rayleigh-Taylor and Richtmyer-Meshkov instabilities. The second
test is a classic Rayleigh-Taylor instability, where a heavy fluid is supported
against the force of gravity by a light fluid. Our simulations of the
multi-layer target experiments showed good agreement with the experimental
results, but our simulations of the Rayleigh-Taylor instability did not agree
well with the experimental results. We discuss our findings and present results
of additional simulations undertaken to further investigate the Rayleigh-Taylor
instability.Comment: 76 pages, 26 figures (3 color), Accepted for publication in the ApJ
Leptomeningeal disease and brain control after postoperative stereotactic radiosurgery with or without immunotherapy for resected brain metastases
Purpose Immunotherapy has shown activity in patients with brain metastases (BM) and leptomeningeal disease (LMD). We have evaluated LMD and intraparenchymal control rates for patients with resected BM receiving postoperative stereotactic radiosurgery (SRS) and immunotherapy or postoperative SRS alone. We hypothesize that postoperative SRS and immunotherapy will result in a lower rate of LMD with acceptable toxicity compared with postoperative SRS. Patients and methods One hundred and twenty-nine patients with non-small-cell lung cancer (NSCLC) and melanoma BM who received postoperative fractionated SRS (fSRS; 3Ă—9 Gy) in combination with immunotherapy or postoperative fSRS alone for completely resected BM were retrospectively evaluated. The primary endpoint of the study was the rate of LMD after treatments. The secondary endpoints were local failure, distant brain parenchymal failure (DBF), overall survival (OS), and treatment-related toxicity. Results Sixty-three patients received postoperative SRS and immunotherapy, either nivolumab or pembrolizumab, and 66 patients received postoperative SRS alone to the resection cavity. With a median follow-up of 15 months, LMD occurred in 19 patients: fSRS group, 14; fSRS and immunotherapy, 5. The 12-month LMD cumulative rates were 22% (95% CI 14% to 37%) in the fSRS group and 6% (95% CI 2% to 17%) in the combined treatment group (p=0.007). Resection cavity control was similar between the groups, whereas DBF and OS were significantly different; the 1-year DBF rates were 31% (95% CI 20% to 46%) in the fSRS and immunotherapy group and 52% (95% CI 39% to 68%) in the fSRS group; respective OS rates were 78% (95% CI 67% to 88%) and 58.7% (95% CI 47% to 70%). Twenty-two patients undergoing postoperative fSRS and immunotherapy and nine subjected to postoperative fSRS experienced treatment-related imaging changes suggestive of radiation-induced brain necrosis (p=0.02). Conclusions Postoperative fSRS in combination with immunotherapy decreases the incidence of LMD and DBF in patients with resected BM from NSCLC and melanoma as compared with fSRS alone, reducing the rate of neurological death and prolonging survival
Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson\u2019s disease
Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson\u2019s disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory
Molecular Insights into the Genetic Diversity of Garcinia cambogia Germplasm Accessions
- …