Halloysite nanotubes as nano-carriers of corrosion inhibitors in cement formulations

The ingress of water, as a vehicle for many harmful substances, is the main cause of all the major physical and chemical degradation processes affecting concrete buildings. To prevent damage and protect concrete surfaces, coatings are generally used. Cement-based coatings in particular can act as a physical barrier and reduce the permeability of surfaces. In case of chloride-induced corrosion, corrosion inhibitors are also generally used, and nano-carriers have been proven to provide a long-term protective effect. In this work, we designed a surface protection cementitious coating enhanced with nano-silica and halloysite nanotubes (HNTs). HNTs were loaded with a corrosion inhibitor, benzotriazole (BTA), and used as nano-reservoir, while nano-silica was used to improve the structure of the protective coating and to strengthen its adhesion to the surface of application. The cementitious coatings were characterized with a multi-technique approach including thermal and spectroscopic analysis, scanning electron microscopy, specific surface area and pore size distribution, and Vickers hardness test. The release of BTA was monitored through UV-vis analysis, and the transportation of BTA through coated mortars was studied in simulated rain conditions. We evidenced that the presence of silica densifies the porous structure and increases the interfacial bond strength between the protective coating and the surface of application. We report here, for the first time, that HNTs can be used as nano-carriers for the slow delivery of anti-corrosion molecules in cement mortars

Precision Anti-Cancer Medicines by Oligonucleotide Therapeutics in Clinical Research Targeting Undruggable Proteins and Non-Coding RNAs

Cancer incidence and mortality continue to increase, while the conventional chemotherapeutic drugs confer limited efficacy and relevant toxic side effects. Novel strategies are urgently needed for more effective and safe therapeutics in oncology. However, a large number of proteins are considered undruggable by conventional drugs, such as the small molecules. Moreover, the mRNA itself retains oncological functions, and its targeting offers the double advantage of blocking the tumorigenic activities of the mRNA and the translation into protein. Finally, a large family of non-coding RNAs (ncRNAs) has recently emerged that are also dysregulated in cancer, but they could not be targeted by drugs directed against the proteins. In this context, this review describes how the oligonucleotide therapeutics targeting RNA or DNA sequences, are emerging as a new class of drugs, able to tackle the limitations described above. Numerous clinical trials are evaluating oligonucleotides for tumor treatment, and in the next few years some of them are expected to reach the market. We describe the oligonucleotide therapeutics targeting undruggable proteins (focusing on the most relevant, such as those originating from the MYC and RAS gene families), and for ncRNAs, in particular on those that are under clinical trial evaluation in oncology. We highlight the challenges and solutions for the clinical success of oligonucleotide therapeutics, with particular emphasis on the peculiar challenges that render it arduous to treat tumors, such as heterogeneity and the high mutation rate. In the review are presented these and other advantages offered by the oligonucleotide as an emerging class of biotherapeutics for a new era of precision anti-cancer medicine

Laser induced fluorescence for axion dark matter detection: a feasibility study in YLiF4_4:Er3+^{3+}

We present a detection scheme to search for QCD axion dark matter, that is based on a direct interaction between axions and electrons explicitly predicted by DFSZ axion models. The local axion dark matter field shall drive transitions between Zeeman-split atomic levels separated by the axion rest mass energy $m_a c^2$. Axion-related excitations are then detected with an upconversion scheme involving a pump laser that converts the absorbed axion energy ($\sim$ hundreds of $\mu$eV) to visible or infrared photons, where single photon detection is an established technique. The proposed scheme involves rare-earth ions doped into solid-state crystalline materials, and the optical transitions take place between energy levels of $4f^N$ electron configuration. Beyond discussing theoretical aspects and requirements to achieve a cosmologically relevant sensitivity, especially in terms of spectroscopic material properties, we experimentally investigate backgrounds due to the pump laser at temperatures in the range $1.9-4.2$ K. Our results rule out excitation of the upper Zeeman component of the ground state by laser-related heating effects, and are of some help in optimizing activated material parameters to suppress the multiphonon-assisted Stokes fluorescence.Comment: 8 pages, 5 figure

Particle detection through the quantum counter concept in YAG:Er3+^{3+}

We report about a novel scheme for particle detection based on the infrared quantum counter concept. Its operation consists of a two-step excitation process of a four level system, that can be realized in rare earth-doped crystals when a cw pump laser is tuned to the transition from the second to the fourth level. The incident particle raises the atoms of the active material into a low lying, metastable energy state, triggering the absorption of the pump laser to a higher level. Following a rapid non-radiative decay to a fluorescent level, an optical signal is observed with a conventional detectors. In order to demonstrate the feasibility of such a scheme, we have investigated the emission from the fluorescent level $^4$S$_{3/2}$ (540 nm band) in an Er$^{3+}$-doped YAG crystal pumped by a tunable titanium sapphire laser when it is irradiated with 60 keV electrons delivered by an electron gun. We have obtained a clear signature this excitation increases the $^{4}I_{13/2}$ metastable level population that can efficiently be exploited to generate a detectable optical signal

Are bullies more productive? Empirical study of affectiveness vs. issue fixing time

Human Affectiveness, i.e., The emotional state of a person, plays a crucial role in many domains where it can make or break a team's ability to produce successful products. Software development is a collaborative activity as well, yet there is little information on how affectiveness impacts software productivity. As a first measure of this impact, this paper analyzes the relation between sentiment, emotions and politeness of developers in more than 560K Jira comments with the time to fix a Jira issue. We found that the happier developers are (expressing emotions such as JOY and LOVE in their comments), the shorter the issue fixing time is likely to be. In contrast, negative emotions such as SADNESS, are linked with longer issue fixing time. Politeness plays a more complex role and we empirically analyze its impact on developers' productivity

Closed-Loop Manufacturing for Aerospace Industry: An Integrated PLM-MOM Solution to Support the Wing Box Assembly Process

The aim of this research is to provide an example of the importance that integrated Product Lifecycle Management (PLM) and Manufacturing Operation Management (MOM) systems have in realizing the Digital Manufacturing. The research first examines what the Digital Manufacturing involves and then identifies Digital Twin and the related Digital Thread as key elements. PLM and MOM solutions support the Digital Twin and the Digital Thread allowing the exchange of product-related information between the digital manufacturing model and the physical manufacturing execution. A Digital Twin of a wing box and its assembly process is created in PLM by building the bill of material and bill of process. Then it is shown how in MOM system the production phase is facilitated by managing production operations, advanced scheduling and supporting the execution of the processes and how the analysis of the manufacturing performance is possible. The result integrating these systems is to have the right information at the right place at the right time along with the related benefits in terms of costs, time and quality. The activity has been developed in Siemens Industry Software under the European Project AirGreen 2, an integrated research action of the REG IADP (Regional Innovative Aircraft Demonstration Platform) part of the Joint Technical Programme, the steering and coordination of LEONARDO Aircraft. The AirGreen 2 project is an Innovation Action funded by the Clean Sky 2 Joint Undertaking under the European Union\u2019s Horizon 2020 research and innovation programme, under Grant Agreement N\ub0807089 REG IADP)