295 research outputs found
Administrative-Curricular Role of the County Superintendent of Schools in Oklahoma
Educational Administratio
Glass Solder Approach for Robust, Low-Loss, Fiber-to-Waveguide Coupling
The key advantages of this approach include the fact that the index of interface glass (such as Pb glass n = 1.66) greatly reduces Fresnel losses at the fiber-to-waveguide interface, resulting in lower optical losses. A contiguous structure cannot be misaligned and readily lends itself for use on aircraft or space operation. The epoxy-free, fiber-to-waveguide interface provides an optically pure, sealed interface for low-loss, highpower coupling. Proof of concept of this approach has included successful attachment of the low-melting-temperature glass to the x-y plane of the crystal, successful attachment of the low-meltingtemperature glass to the end face of a standard SMF (single-mode fiber), and successful attachment of a wetted lowmelting- temperature glass SMF to the end face of a KTP crystal. There are many photonic components on the market whose performance and robustness could benefit from this coupling approach once fully developed. It can be used in a variety of fibercoupled waveguide-based components, such as frequency conversion modules, and amplitude and phase modulators. A robust, epoxy-free, contiguous optical interface lends itself to components that require low-loss, high-optical-power handling capability, and good performance in adverse environments such as flight or space operation
Determination of Small Molecule ABAD Inhibitors Crossing Blood Brain Barrier and Pharmacokinetics
A major obstacle to the development of effective treatment of Alzheimer’s disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid beta peptide (Aβ) with amyloid-beta binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD inhibitors in mouse plasma, brain and artificial cerebrospinal fluid has been developed and validated based on high performance liquid chromatography tandem mass spectrometry. Mass spectra were generated using Micromass Quattro Ultima “triple” quadrupole mass spectrometer equipped with Electrospray ionization interface. Good linearity was obtained over a concentration range of 0.05–2.5 µg/ml. The lowest limit of quantification and detection was 0.05µg/ml. All inter-day accuracies and precisions were within ±15% of the nominal value and ±20%, respectively, at the lower limit of quantitation. The tested compounds were stable at various conditions with recoveries >90.0 % (RSD<10%). The method used for pharmacokinetic studies of compounds in mouse cerebrospinal fluid, plasma, and brain is accurate, precise, and specific with no matrix effect. Pharmacokinetic data showed these compounds penetrate the blood–brain barrier (BBB) yielding 4–50 ng/ml peak brain concentrations and 2 µg/ml peak plasma concentrations from a 10mg/kg dose. These results indicate that our newly synthesized small molecule ABAD inhibitor have good drug properties with the ability to cross the blood brain barrier, which holds a great potential for AD therapy
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Family Health Development in Life Course Research: A Scoping Review of Family Functioning Measures.
BACKGROUND AND OBJECTIVES: Our objective is to identify common family functioning measurement tools and assess their compatibility with family-health development and life-course perspectives. METHODS: Data sources include PubMed, ERIC, CINAHL, Families and Societies Worldwide, PsychInfo, Web of Science, PsychNet, and Health and Psychosocial Instruments. Title and abstract screening and full-text review of articles were conducted by multiple reviewers based on prespecified inclusion criteria. Data extraction focused on features of identified measurements tools, including: (1) name (2) domains of family functioning measured, (3) established psychometric properties, and (4) original context of psychometric evaluation (eg, details about the study sample). RESULTS: Of the 50 measurement tools identified, 94% measured organizational patterns (eg, flexibility, connectedness, or resources), 46% measured belief systems (eg, making meaning of adversity, or positive outlook), and 54% measured communication processes (eg, open emotional sharing, or collaborative problem-solving). CONCLUSIONS: Existing measures of family functioning can aid life-course researchers in understanding family processes as contexts for health and well-being. There also remain opportunities to refine or develop measures of family functioning more compatible with a life-course perspective that assess family processes (1) at various life stages; (2) with various backgrounds, identities, structures, and experiences; and (3) embedded in or impacted by various contexts that may facilitate or hinder family functioning
Direct Numerical Simulation of Radiation Pressure-Driven Turbulence and Winds in Star Clusters and Galactic Disks
[abridged] The pressure exerted by the radiation of young stars may be an
important feedback mechanism in forming star clusters and the disks of
starburst galaxies. However, there is great uncertainty in how efficiently
radiation couples to matter in these high optical depth environments. In
particular, it is unclear what levels of turbulence the radiation can produce,
and whether the infrared radiation trapped by the dust opacity can give rise to
heavily mass-loaded winds. In this paper we report a series of two-dimensional
flux-limited diffusion radiation-hydrodynamics calculations performed with the
code ORION in which we drive strong radiation fluxes through columns of dusty
matter confined by gravity. We consider both systems where the radiation flux
is sub-Eddington throughout the gas column, and where it is super-Eddington at
the midplane but sub-Eddington in the atmosphere. In the latter, we find that
the radiation-matter interaction gives rise to radiation-driven Rayleigh-Taylor
instability, which drives supersonic turbulence at a level sufficient to fully
explain the turbulence seen in Galactic protocluster gas clouds, and to make a
non-trivial contribution to the turbulence observed in starburst galaxy disks.
However, the instability also produces a channel structure in which the
radiation-matter interaction is reduced because the radiation field is not
fully trapped. For astrophysical parameters relevant to forming star clusters
and starburst galaxies, we find that this effect reduces the net momentum
deposition rate in the dusty gas by a factor of ~2-6 compared to simple
analytic estimates, and that in steady state the Eddington ratio reaches unity
and there are no strong winds. We provide an approximation formula, appropriate
for implementation in analytic models and non-radiative simulations, for the
force exerted by the infrared radiation field in this regime.Comment: 20 pages, 11 figures, emulateapj format, accepted to ApJ. This
version has extra discussion, but the results are unchanged. For movies of
simulation results, see http://www.ucolick.org/~krumholz/downloads.htm
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Estimating age of mature adults from the degeneration of the sternal end of the clavicle
The sternal end of the clavicle has been illustrated to be useful in aging young adults, however, no studies have investigated what age-related changes occur to the sternal end post epiphyseal fusion. In this study, three morphological features (i.e., surface topography, porosity, and osteophyte formation) were examined and scored using 564 clavicles of individuals of European ancestry (n = 318 males; n = 246 females), with known ages of 40+ years, from four documented skeletal collections: Hamann-Todd, Pretoria, St. Bride's, and Coimbra. An ordinal scoring method was developed for each of the three traits. Surface topography showed the strongest correlation with age, and composite scores (formed by summing the three separate trait scores) indicated progressive degeneration of the surface with increasing chronological age. Linear regression analyses were performed on the trait scores to produce pooled-sample age estimation equations. Blind tests of the composite score method and regression formulae on 56 individuals, aged 40+ years, from Christ Church Spitalfields, suggest accuracies of 96.4% for both methods. These preliminary results display the first evidence of the utility of the sternal end of the clavicle in aging older adult individuals. However, in the current format, these criteria should only be applied to individuals already identified as over 40 years in order to refine the age ranges used for advanced age. These findings do suggest the sternal end of the clavicle has potential to aid age estimates beyond the traditional "mature adult" age category (i.e., 46+ years), and provides several suggestions for future research
Measuring and Correcting Wind-Induced Pointing Errors of the Green Bank Telescope Using an Optical Quadrant Detector
Wind-induced pointing errors are a serious concern for large-aperture
high-frequency radio telescopes. In this paper, we describe the implementation
of an optical quadrant detector instrument that can detect and provide a
correction signal for wind-induced pointing errors on the 100m diameter Green
Bank Telescope (GBT). The instrument was calibrated using a combination of
astronomical measurements and metrology. We find that the main wind-induced
pointing errors on time scales of minutes are caused by the feedarm being blown
along the direction of the wind vector. We also find that wind-induced
structural excitation is virtually non-existent. We have implemented offline
software to apply pointing corrections to the data from imaging instruments
such as the MUSTANG 3.3 mm bolometer array, which can recover ~70% of
sensitivity lost due to wind-induced pointing errors. We have also performed
preliminary tests that show great promise for correcting these pointing errors
in real-time using the telescope's subreflector servo system in combination
with the quadrant detector signal.Comment: 17 pages, 11 figures; accepted for publication in PAS
A selective procedure for the field isolation of pathogenic Streptococcus spp. of rainbow trout (Salmo gairdneri)
A procedure established for the selective isolation of the species of Streptococcus responsible for rainbow trout streptococcosis in South Africa, consisted of the inoculation of samples into nutrient broth which had been supplemented with 100 µg/ml of nalidixic acid, 160 µg/ml of oxolinic acid or 200 µg/ml of sodium azide. After incubation, the sample was plated onto tetrazolium agar on which the rainbow trout pathogenic Streptococcus species grew as a red colony. The colonies were isolated from the tetrazolium agar and identified as rainbow trout pathogenic isolates by biochemical and serological tests. In the laboratory the selective procedure is capable of detecting about 2 bacteria per ml. This procedure was used in the field and biochemically identical Streptococcus species were found in the mud and a freshwater crab from the water source of a site with a history of streptococcosis.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.lmchunu2014mn201
Metagenomic analysis of DNA viruses with targeted sequence capture of canine lobular orbital adenomas and normal conjunctiva
Our study aims are: (1) to evaluate phenotypically normal canine conjunctival and orbital tissue and tissue from canine lobular orbital adenomas (CLOAs) for the presence of viral genomic material and (2) phylogenetically classify detected DNA viruses to determine if a DNA virus is associated with CLOAs. A total of 31 formalin fixed paraffin embedded CLOA tissue samples, 4 papillomas or sarcoid, and 10 fresh clinically normal conjunctival tissues were included in this study. Genomic DNA was isolated from all samples and sequencing libraries were prepared. The libraries were molecularly indexed and pooled and viral DNA was enriched via targeted sequence capture utilizing ViroCap. The libraries were sequenced on the Illumina HiSeq platform and compared to known viral DNA reference genomes to identify viral DNA. Carnivore parvovirus was identified in 6.4% and 20% of CLOA tissue and normal conjunctival samples, respectively. This study showed that conjunctival tissue from healthy dogs and CLOAs uncommonly harbor DNA viruses, and no DNA virus was associated with these tumors. Further studies are needed to evaluate the etiologic cause of CLOAs
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