Evaluation of the Brief Wisconsin Inventory of Smoking Dependence Motives in African-American and European-American Heavy Smokers

Introduction: Emerging evidence indicates that nicotine dependence should be measured multidimensionally. A brief version of the Wisconsin Inventory of Smoking Dependence Motives (WISDM) has recently been developed in which the item count has been reduced from 68 to 37. The objectives of this study were to replicate the initial findings in a larger heavy-smoking sample, and determine whether the WISDM structure is applicable to both African-American (AA) and European-American (EA) heavy smokers. Methods: Smokers were selected from our Mid-South Tobacco Family and Case–Control studies. Available data from 2,522 smokers was selected, involving 1,633 AA and 889 EA participants. Both exploratory and confirmatory analyses were employed to evaluate the psychometric characteristics of the Brief WISDM. Results: AAs and EAs were similar in age, sex, education, marital status, cigarettes per day, and Fagerström Test for Nicotine Dependence score. Internal consistency evaluations for Brief WISDM subscales were adequate but generally lower than that of the full-scale version. Confirmatory factor analyses did not yield desirable fits for AA or EA smokers. Exploratory factor analysis revealed good agreement for item loadings on the four primary dependence motives subscales (Automaticity, Loss of Control, Craving, and Tolerance) but discrepancies on all secondary dependence motives subscales except Taste/Sensory Processes. Specific item loadings for subscales differed by ethnicity. Conclusion: The Brief WISDM demonstrated reasonable psychometric properties in our large sample. Together, we provide support for the general validity of the brief form but suggest individual item selections may benefit from further investigation

Preparation and Use of Preconstructed Orders, Order Sets, and Order Menus in a Computerized Provider Order Entry System

Objective: To describe the configuration and use of the computerized provider order entry (CPOE) system used for inpatient and outpatient care at the authors' facility. Design: Description of order configuration entities, use patterns, and configuration changes in a production CPOE system. Measurements: The authors extracted and analyzed the content of order configuration entities (order dialogs, preconfigured [quick] orders, order sets, and order menus) and determined the number of orders entered in their production order entry system over the previous three years. The authors measured use of these order configuration entities over a six-month period. They repeated the extract two years later to measure changes in these entities. Results: CPOE system configuration, conducted before and after first production use, consisted of preparing 667 order dialogs, 5,982 preconfigured (quick) orders, and 513 order sets organized in 703 order menus for particular contexts, such as admission for a particular diagnosis. Fifty percent of the order dialogs, 57% of the quick orders, and 13% of the order sets were used within a six-month period. Over the subsequent two years, the volume of order configuration entities increased by 26%. Conclusions: These order configuration steps were time-consuming, but the authors believe they were important to increase the ordering speed and acceptability of the order entry software. Lessons learned in the process of configuring the CPOE ordering system are given. Better understanding of ordering patterns may make order configuration more efficient because many of the order configuration entities that were created were not used by clinician

Psychosocial Interventions Delivered by Primary Care Physicians to Patients with Depression

Few high-quality studies have been conducted examining the effectiveness of psychosocial interventions performed by primary care physicians for patients with major depression. Two randomized controlled clinical trials (RCTs) found that a psychosocial intervention, specifically problem-solving therapy, is as effective as pharmacotherapy for symptoms of major depression. (Strength of recommendation: B) However, these results should be interpreted with some degree of caution because of the limited number of studies and their small sample size

Which anthropometric and lower body power variables are predictive of professional and amateur playing status in male rugby union players?

The purpose of this study was to compare anthropometric and lower body power measurements between current professional and amateur male rugby union players. The present study also sought to determine which anthropometric and physical performance variables were predictive of playing standard. Thirty professional and 30 amateur RU players performed Wattbike 6 s maximal effort (WB6S) and countermovement (CMJ) and squat jump (SJ) assessments, anthropometric measures were also taken. Dependant variables recorded and analysed including: body mass, stature, Σ8 site skinfolds, WB6S absolute and relative peak power, CMJ and SJ average concentric force, jump height, peak velocity, time to peak force, rate of force development (RFD) and absolute and relative peak force and power. Professional players were heavier, taller and leaner than their amateur counterparts (p < 0.05). Professional players performed significantly better in all physical performance measures except CMJ and SJ time to peak force, CMJ RFD and SJ relative peak force. Variables which were predictive of playing standard were: Σ8 skinfolds, CMJ peak velocity and WB6S absolute and relative peak power (p < 0.05). These findings indicate that the current body of male professional RU players is anthropometrically and physically superior to their amateur counterparts, although not all variables assessed here were predictive of playing standard. Data presented here indicate that Σ8 skinfolds, WB6S absolute and relative power and CMJ peak velocity are predictive of playing standard, whereas other anthropometric and strength and power variables are not

How much does smoking cessation cut CHD risk?

Patients with coronary heart disease (CHD) who refrain from smoking over a 2-year follow-up period decrease their relative risk (RR) for morbidity and mortality by about one third (strength of recommendation [SOR]: A, meta-analysis of 20 cohort studies). People who maintain abstinence after coronary artery bypass surgery are more likely to avoid angina, repeat revascularization, significant physical impairment, and CHD-related hospital admissions than patients who continue to smoke (SOR: A, 4 cohort studies with 1- to 20-year follow-up)

Incorporating Ethics in Computing Courses: Perspectives from Educators

Incorporating ethics into computing education has become a priority for the SIGCSE community. Many computing departments and educators have contributed to this endeavor by creating standalone computing ethics courses or integrating ethics modules and discussions into preexisting curricula. In this study, we hope to support this effort by reporting on computing educators' attitudes toward including ethics in their computing classroom, with a special focus on the structures that hinder or help this endeavor. We surveyed 138 higher education computing instructors to understand their attitudes toward including ethics in their classes, what barriers might be preventing them from doing so, and which structures best support them. We found that even though instructors were generally positive about ethics as a component of computing education, there are specific barriers preventing ethics from being included in some computing courses. In this work, we explore how to alleviate these barriers and outline support structures that could encourage further integration of ethics and computing in higher education

Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking

We previously reported that catechol-O-methyltransferase (COMT) is significantly associated with nicotine dependence (ND) in humans. In this study, we examined whether there exists any difference in the extent of methylation of CpG dinucleotides in the promoter region of COMT in smokers and non-smokers by analyzing the methylation status of cytosines at 33 CpG sites through direct sequencing of bisulfite-treated DNA (N = 50 per group). The cytosine was methylated at 13 of 33 CpG sites, and two of these sites showed significant differences between smokers and matched non-smoker controls. Specifically, in the −193 CpG site, the degree of methylation was 19.1% in smokers and 13.2% in non-smokers (P < 0.01). This finding was confirmed by methylation-specific PCR using an additional 100 smoker and 100 non-smoker control samples, which showed the degree of methylation to be 22.2% in smokers and 18.3% in non-smokers (P < 0.01). For the −39 CpG site, the degree of methylation was 9.2% in smokers, whereas no methylation was found in non-smoker controls. Together, our findings provide the first molecular explanation at the epigenetic level for the association of ND with methylation of the COMT promoter, implying that methylation plays a role in smoking dependence

Peatland initiation and carbon accumulation in the Falkland Islands

The Falkland Islands in the South Atlantic Ocean contain extensive peatlands at the edge of their global climatic envelope, but the long-term carbon dynamics of these sites is poorly quantified. We present new data for ten sites, compile previously-published data and produce a new synthesis. Many peatlands in the Falkland Islands developed notably early, with a fifth of basal 14 C dates pre-Holocene. Falkland Islands peats have high ash content, high carbon content and high bulk density compared to global norms. In many sites carbon accumulation rates are extremely low, which may partly relate to low average rainfall, or to carbon loss through burning and aeolian processes. However, in coastal Tussac peatlands carbon accumulation can be extremely rapid. Our re-analysis of published data from Beauchene Island, the southernmost of the Falkland Islands, yields an exceptional long-term apparent carbon accumulation rate of 139 g C m −2 yr −1 , to our knowledge the highest recorded for any global peatland. This high accumulation might relate to the combination of a long growing-season and marine nutrient inputs. Given extensive coverage and carbon-dense peats the carbon stock of Falkland Islands peatlands is clearly considerable but robust quantification will require the development of a reliable peat map. Falkland Island peatlands challenge many standard assumptions and deserve more detailed study

Radio-Continuum study of the Nearby Sculptor Group Galaxies. Part 1: NGC 300 at lambda = 20 cm

A series of new radio-continuum (lambda=20 cm) mosaic images focused on the NGC 300 galactic system were produced using archived observational data from the VLA and/or ATCA. These new images are both very sensitive (rms=60 microJy) and feature high angular resolution (<10"). The most prominent new feature is the galaxy's extended radio-continuum emission, which does not match its optical appearance. Using these newly created images a number of previously unidentified discrete sources have been discovered. Furthermore, we demonstrate that a joint deconvolution approach to imaging this complete data-set is inferior when compared to an immerge approach.Comment: 13 pages, 12 figures, accepted to APSS, new version to correct the missing reference