1,517 research outputs found
Unhappiness, health and cognitive ability in old age
Background To test whether scores on depression inventories on entry to a longitudinal study predict mental ability over the next 4â16 years. Method Associations between scores on the Beck Depression Inventory and on tests of intelligence, vocabulary and memory were analysed in 5070 volunteers aged 49â93 years after differences in prescribed drug consumption, death and drop-out, sex, socio-economic advantage and recruitment cohort effects had also been considered. Results On all cognitive tasks Beck scores on entry, even in the range 0â7 indicating differences in above average contentment, affected overall levels of cognitive performance but not rates of age-related cognitive decline suggesting effects of differences in life satisfaction rather than in depression. Conclusions A new finding is that, in old age, increments in life satisfaction are associated with better cognitive performance. Implications for interpreting associations between depression inventory scores and cognitive performance in elderly samples are discussed
Neural Dynamics in Parkinsonian Brain:The Boundary Between Synchronized and Nonsynchronized Dynamics
Synchronous oscillatory dynamics is frequently observed in the human brain.
We analyze the fine temporal structure of phase-locking in a realistic network
model and match it with the experimental data from parkinsonian patients. We
show that the experimentally observed intermittent synchrony can be generated
just by moderately increased coupling strength in the basal ganglia circuits
due to the lack of dopamine. Comparison of the experimental and modeling data
suggest that brain activity in Parkinson's disease resides in the large
boundary region between synchronized and nonsynchronized dynamics. Being on the
edge of synchrony may allow for easy formation of transient neuronal
assemblies
X-ray Binaries and Globular Clusters in Elliptical Galaxies
The X-ray emission from normal elliptical galaxies has two major components:
soft emission from diffuse gas and harder emission from populations of
accreting (low-mass) stellar X-ray binaries (LMXB). If LMXB populations are
tied to the field stellar populations in galaxies, their total X-ray
luminosities should be proportional to the optical luminosities of galaxies.
However, recent ASCA and Chandra X-ray observations show that the global
luminosities of LMXB components in ellipticals exhibit significant scatter at a
given optical luminosity. This scatter may reflect a range of evolutionary
stages among LMXB populations in ellipticals of different ages. If so, the
ratio of the global LMXB X-ray luminosity to the galactic optical luminosity,
L_LMXB/L_opt, may be used to determine when the bulk of stars were formed in
individual ellipticals. To test this, we compare variations in L_LMXB/L_opt for
LMXB populations in ellipticals to optically-derived estimates of stellar ages
in the same galaxies. We find no correlation, implying that L_LMXB/L_opt
variations are not good age indicators for ellipticals. Alternatively, LMXBs
may be formed primarily in globular clusters (through stellar tidal
interactions), rather than in the stellar fields of galaxies. Since elliptical
galaxies exhibit a wide range of globular cluster populations for a given
galaxian luminosity, this may induce a dispersion in the LMXB populations of
ellipticals with similar optical luminosities. Indeed, we find that
L_LMXB/L_opt ratios for LMXB populations are strongly correlated with the
specific globular cluster frequencies in elliptical galaxies. This suggests
that most LMXBs were formed in globular clusters.Comment: 5 pages, emulateapj5 style, 2 embedded EPS figures, to appear in ApJ
Letter
Modeling the origin of parkinsonian tremor
poster abstractEven though much is known about the biophysics, anatomy and physiology of basal ganglia networks, the cellular and network basis of parkinsonian tremor remains an open question. Multiple experimental data suggest that the physiological origin of parkinsonian tremor is different from the physiological origin of other parkinsonian motor symptoms. However, the exact origin of the tremor genesis in Parkinsonâs disease remains unknown. A large body of experimental evidence supports the hypothesis, that the tremor arises due to pathological interaction of potentially oscillatory cells within the loop formed by basal ganglia and thalamocortical circuits. We suggest a model of this circuitry, which helps to clarify this potential mechanism of tremor genesis
Cortical oxygenation suggests increased effort during cognitive inhibition in ecstasy polydrug users
Background: It is understood that 3,4-methylenedioxymethamphetamine (ecstasy) causes serotonin dysfunction and deficits in executive functioning. When investigating executive function, functional neuroimaging allows the physiological changes underlying these deficits to be investigated. The present study investigated behavioural and brain indices of inhibition in ecstasy-polydrug users. Methods: Twenty ecstasy-polydrug users and 20 drug-naĂŻve participants completed an inhibitory control task (Random Letter Generation (RLG)) while prefrontal haemodynamic response was assessed using functional near infrared spectroscopy (fNIRS). Results: There were no group differences on background measures including sleep quality and mood state. There were also no behavioural differences between the two groups. However, ecstasy-polydrug users displayed significant increases in oxygenated haemoglobin (oxy-Hb) from baseline compared to controls at several voxels relating to areas of the inferior right medial prefrontal cortex, as well the right and left dorsolateral prefrontal cortex. Regression analysis revealed that recency of ecstasy use was a significant predictor of oxy-Hb increase at two voxels over the right hemisphere after controlling for alcohol and cannabis use indices. Conclusion: Ecstasy-polydrug users show increased neuronal activation in the prefrontal cortex compared to non-users. This is taken to be compensatory activation/recruitment of additional resources to attain similar performance levels on the task, which may be reversible with prolonged abstinence
Fine temporal structure of beta-band synchronization in Parkinsonâs disease: experiments, models and mechanisms
Double Neutron Star Systems and Natal Neutron Star Kicks
We study the four double neutron star systems found in the Galactic disk in
terms of the orbital characteristics of their immediate progenitors and the
natal kicks imparted to neutron stars. Analysis of the effect of the second
supernova explosion on the orbital dynamics, combined with recent results from
simulations of rapid accretion onto neutron stars lead us to conclude that the
observed systems could not have been formed had the explosion been symmetric.
Their formation becomes possible if kicks are imparted to the radio-pulsar
companions at birth. We identify the constraints imposed on the immediate
progenitors of the observed double neutron stars and calculate the ranges
within which their binary characteristics (orbital separations and masses of
the exploding stars) are restricted. We also study the dependence of these
limits on the magnitude of the kick velocity and the time elapsed since the
second explosion. For each of the double neutron stars, we derive a minimum
kick magnitude required for their formation, and for the two systems in close
orbits we find it to exceed 200km/s. Lower limits are also set to the
center-of-mass velocities of double neutron stars, and we find them to be
consistent with the current proper motion observations.Comment: 25 pages, 6 figs (9 parts), 4 tables, AASTeX, Accepted in Ap
The Intrinsic Origin of Spin Echoes in Dipolar Solids Generated by Strong Pi Pulses
In spectroscopy, it is conventional to treat pulses much stronger than the
linewidth as delta-functions. In NMR, this assumption leads to the prediction
that pi pulses do not refocus the dipolar coupling. However, NMR spin echo
measurements in dipolar solids defy these conventional expectations when more
than one pi pulse is used. Observed effects include a long tail in the CPMG
echo train for short delays between pi pulses, an even-odd asymmetry in the
echo amplitudes for long delays, an unusual fingerprint pattern for
intermediate delays, and a strong sensitivity to pi-pulse phase. Experiments
that set limits on possible extrinsic causes for the phenomena are reported. We
find that the action of the system's internal Hamiltonian during any real pulse
is sufficient to cause the effects. Exact numerical calculations, combined with
average Hamiltonian theory, identify novel terms that are sensitive to
parameters such as pulse phase, dipolar coupling, and system size.
Visualization of the entire density matrix shows a unique flow of quantum
coherence from non-observable to observable channels when applying repeated pi
pulses.Comment: 24 pages, 27 figures. Revised from helpful referee comments. Added
new Table IV, new paragraphs on pages 3 and 1
Associative memory storing an extensive number of patterns based on a network of oscillators with distributed natural frequencies in the presence of external white noise
We study associative memory based on temporal coding in which successful
retrieval is realized as an entrainment in a network of simple phase
oscillators with distributed natural frequencies under the influence of white
noise. The memory patterns are assumed to be given by uniformly distributed
random numbers on so that the patterns encode the phase differences
of the oscillators. To derive the macroscopic order parameter equations for the
network with an extensive number of stored patterns, we introduce the effective
transfer function by assuming the fixed-point equation of the form of the TAP
equation, which describes the time-averaged output as a function of the
effective time-averaged local field. Properties of the networks associated with
synchronization phenomena for a discrete symmetric natural frequency
distribution with three frequency components are studied based on the order
parameter equations, and are shown to be in good agreement with the results of
numerical simulations. Two types of retrieval states are found to occur with
respect to the degree of synchronization, when the size of the width of the
natural frequency distribution is changed.Comment: published in Phys. Rev.
The landscape of gifted and talented education in England and Wales: How are teachers implementing policy?
This is an Author's Accepted Manuscript of an article published in Research Papers in Education, 27(2), 167-186, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02671522.2010.509514.This paper explores the evidence relating to how primary schools are responding to the âgifted and talentedâ initiative in England and Wales. A questionnaire survey which invited both closed and open-ended responses was carried out with a national sample of primary schools. The survey indicated an increasing proportion of coordinators, compared with a survey carried out in 1996, were identifying their gifted and talented children as well as having associated school policies. However, the survey also highlighted a number of issues which need addressing if the initiative is to achieve its objective of providing the best possible educational opportunities for children. For example, it was found that a significant number of practitioners were not aware of the existence of the National Quality Standards for gifted and talented education, provided by the UK government in 2007, and the subject-specific criteria provided by the UKâs Curriculum Authority for identification and provision have been largely ignored. The process of identifying children to be placed on the âgifted and talentedâ register seems haphazard and based on pragmatic reasons. Analysis of teachersâ responses also revealed a range of views and theoretical positioning held by them, which have implications for classroom practice. As the âgifted and talentedâ initiative in the UK is entering a second decade, and yet more significant changes in policy are introduced, pertinent questions need to be raised and given consideration
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