A Comprehensive Study on Phytochemical Contents, Isolation and Antioxidant Capacities in wild mind, Mentha longifolia subsp. typhoides var. typhoides PH. Davis

The current study is to determine variation in vitro antioxidant activities and chemical contents of different extraction solvents in aerial parts of wild M. longifolia subsp. typhoides var. typhoides taxons from Turkey. The chemical and volatile compounds of M. longifolia were investigated with HPLC-TOF/MS and GC/MS. The highest total phenolic and flavonoid contents were found as 28.27 and 25.42 mg from R6W, respectively. Hesperidin, neohesperidin, taxifolin, fumaric acid, chlorogenic acid, naringin, 4-hydroxybenzoic acid, caffeic acid, protocatechuic acid and syringic acid were determined in all extracts. The linalool, menthone, isomenthone, piperitoneoxide, pulegone, thymol, caryophyllene and caryophylleneoxide were major components in volatile compounds. The highest activities were observed significantly (p < 0.01) from R6M, R6W, R10EA and R5M in total antioxidant, superoxide-scavenging, metal-chelating and inhibition of lipid peroxidation activities, respectively. The isolated menthone (96.00%) was exhibited the higher inhibition of lipid peroxidation than standards. The results validate that M. longifolia possesses as a source of antioxidant potential for medicinal and foods

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

CHEMICAL COMPOSITION AND ANTIFUNGAL ACTIVITY OF SALVIA OFFICINALIS (L.), S. CRYPTANTHA (MONTBRET ET AUCHER EX BENTH.), S. TOMENTOSA (MILL.) PLANT ESSENTIAL OILS AND EXTRACTS

WOS: 000429081700043The essential oils from Salvia officinalis L., S. cryptantha (Montbret et Aucher ex Benth.) and S. tomentosa (Mill.) were extracted with hydrodistillation method and determined by using GC/MS analysis. This study investigated the in vitro effectiveness of essential oils and extracts of S. officinalis, S. cryptantha and S. tomentosa (collected from Tokat province) against eight fungal plant pathogens. Sterile PDA was prepared and then cooled to 40 degrees C, after which the plant essential oils and/or extract were added. PDA without extract was used as negative control, while PDA with a Propineb-containing fungicide was used as positive control. According to the GC/MS analysis, the principal components of S. cryptantha, S. tomentosa and S. officinalis essential oils were determined as eucalyptol (27.64%), Camphor (29.87%), a-pinene (11.91%); beta-thujene (40-69%), borneol (1.79-10.90%), camphor (0.40-7.25%); 3-thujonene (31.95%), camphor (28.53%), eucalyptol (7.35%), respectively. Based on the current results, the plant essential oils and extracts were determined to have negative effects on plant pathogens fungi. These effects changed depending on the extract, the type of sage the essential oil/extract that was obtained, the dose of essential oil or extract, and the fungus species.Gaziosmanpasa University Department of Scientific Research Projects [2011/100]We thank to the Gaziosmanpasa University Department of Scientific Research Projects which supported this study which is a part of 2011/100 numbered doctoral thesis financially

Bazı Kişniş (Coriandrum sativum L.) Genotiplerinin Isparta Koşullarında Verim ve Kalite Özelliklerinin Belirlenmesi

Bu çalışmada; ıslah edilmiş kişniş çeşit ve hatlarının Isparta ekolojik koşularına uyumu ile verim ve kalite özelikleri araştırılmıştır. Çalışma 2017 vejetasyon döneminde Süleyman Demirel Üniversitesi, Tarımsal Araştırma ve Uygulama Merkezi arazilerinde yürütülmüştür. Çalışmada Arslan, Erbaa, Pelmus, Kudret K. Gamze, Gürbüz tescilli çeşitler ile saflaştırılmış Tokat K, Tokat B ve Mardin hatları kullanılmıştır. Tarla denemesi tesadüf blokları deneme desenine göre üç tekrarlamalı olarak yürütülmüştür. Çalışma sonucunda en yüksek biyolojik verim (450 kg/da) ve meyve verimi (113 kg/da) Erbaa çeşidinden elde edilmiştir. Uçucu yağ ve sabit yağ oranları sırasıyla&nbsp; % 0.17-0.33 ile %18.64-22.16 aralıklarında bulunmuştur. Çalışma sonucunda, kozmetik sektörünün önemli olduğu Isparta koşullarında kişniş bitkisinden maksimum 113 kg/da meyve verimi alınabileceği ve bölgenin kişniş üretimi için uygun olduğu belirlenmiştir.&nbsp; Çalışmada ayrıca Erbaa çeşidinin diğer çeşitlerden daha yüksek verim verdiği belirlenmiştir

Farklı zamanlarda ekilen kişniş (Coriandrum sativum L.) populasyonlarının agronomik ve teknolojik özellikleri

Bu çalışma Mardin, Denizli ve Erzurum yörelerinde tarımı yapılan yerel kişniş populasyonlarının Tokat koşullarında yetiştirilebilme potansiyeli ve uygun ekim zamanının belirlenmesi amacıyla 1996 -1997 ve 1997-1998 vegetasyon dönemlerinde yürütülmüştür. Araştırmada biri kışlık (1 Kasım) ve üçü yazlık (1 Mart, 15 Mart ve 1 Nisan) olmak üzere 4 farklı ekim zamanı incelenmiştir. Denemede en yüksek tohum verimi 90.8 kg/da ile Erzurum, en yüksek uçucu yağ oranı ise % 0.39 ile Denizli orjinli bitkilerden elde edilmiştir. Uçucu yağdaki ana bileşen olan linalool oranlarının % 50.52-92.52 arasında değiştiği belirlenmiştir. Araştırmada incelenen özelliklerden bitki boyu (48.5-73.2 cm), dal sayısı (4.5-6.2), şemsiye sayısı (4.7-7.9), biyolojik verim (228.3-347.3 kg/da) ve tohum verimi (67.8-91.1 kg/da) değerleri ekim zamanı geciktikçe azalmıştır. Ekim zamanının 1000 tohum ağırlığı (7.46-7.66), uçucu yağ oranı (% 0.29-0.33), protein oranı (% 14.1-14.8) ve kül oranı (% 6.28-6.78)'na etkisi önemsiz bulunmuştur

Chemical diversity in essential oil composition of Mentha longifolia (L.) Hudson subsp typhoides (Briq.) Harley var. typhoides from Turkey

The essential oil obtained by hydro-distillation of leaf and flower in Mentha longifolia (L.) Hudson subsp. typhoides (Briq.) Harley var. typhoides (Lamiaceae) collected on the flora of Tokat (Black Sea region of Turkey) has been investigated by gas chromatography (GC) and GC-mass spectrometry (GC-MS). As a result of cluster analysis of oil components, four chemotypes - piperitone oxide (PO), piperitone oxide/piperitenone oxide (PO/PNO), p-menthone/piperitone oxide (MN/PO) and trans-dihydrocarvone (DC) - were characterized in both leaf and flower oils. Piperitenone oxide/piperitone oxide (PNO/PO), piperitone oxide/p-menthone/pulegone (PO/MN/PL) and linalool (LI) are distinguished in flower oil, while piperitone oxide/carvacrol/thymol (PO/CR/TH), linalool/isomenthone (LI/IMN) and linalool/piperitone oxide (LI/PO) are distinguished in leaf oil. Samples of the chemotypes have been conserved in botanical garden of Agricultural Research and Application Center in Gaziosmanpasa University for biological activity studies in future.Gaziosmanpaşa Üniversitesi (2008-19

Variation in essential oil composition of coriander (Coriandrum sativum L.) varieties cultivated in two different ecologies

WOS: 000413854600008Coriander, Coriandrum sativum L, is an important medicinal plant belonging to Apiaceae family, which is grown in many parts of Turkey. In this study, essential oil and composition of 6 Turkish coriander cultivars (Gamze, Arslan, Erbaa, Pelmus, Kudret, Gurbuz) were examined in two different (Mardin and Tokat) ecologies. Essential oils were isolated with distillation method in maturated fruits and component composition was determined with gas chromatography-mass spectrometry (GC-MS). Main component was linalool in all cultivar, and it was higher in the conditions of Mardin having a warmer climate in all the cultivars than that of Tokat with temperate climate. Contrary to linalool, -pinene and neryl acetate contents of all cultivar were higher in Tokat