71 research outputs found
RADICAL PROSTATECTOMY FOR PATIENTS WITH CLINICALLY LOCALLY ADVANCED PROSTATE CANCER: RESULTS OF A SINGLE INSTITUTIONAL STUDY
RADICAL PROSTATECTOMY FOR PATIENTS WITH CLINICALLY LOCALLY ADVANCED PROSTATE CANCER: SURVIVAL ANALYSIS AND ONCOLOGICAL OUTCOME
DO PATIENTS TREATED WITH RADICAL PROSTATECTOMY FOR LOCALLY ADVANCED PROSTATE CANCER AND PSA >50 ng/ml HAVE A WORSE PROGNOSIS THAN PATIENTS WITH PSA>20 ng/ml?
Predictive factors for skeletal complications in hormone-refractory prostate cancer patients with metastatic bone disease
Factors predictive of skeletal-related events (SREs) in bone metastatic prostate cancer patients with hormone-refractory disease were investigated. We evaluated the frequency of SREs in 200 hormone-refractory patients consecutively observed at our Institution and followed until death or the last follow-up. Baseline parameters were evaluated in univariate and multivariate analysis as potential predictive factors of SREs. Skeletal-related events were observed in 86 patients (43.0%), 10 of which (5.0%) occurred before the onset of hormone-refractory disease. In univariate analysis, patient performance status (P=0.002), disease extent (DE) in bone (P=0.0001), bone pain (P=0.0001), serum alkaline phosphatase (P=0.0001) and urinary N-telopeptide of type one collagen (P=0.0001) directly correlated with a greater risk to develop SREs, whereas Gleason score at diagnosis, serum PSA, Hb, serum albumin, serum calcium, types of bone lesions and duration of androgen deprivation therapy did not. Both DE in bone (hazard ratio (HR): 1.16, 95% confidence interval (CI): 1.07–1.25, P=0.000) and pain score (HR: 1.13, 95% CI: 1.06–1.20, P=0.000) were independent variables predicting for the onset of SREs in multivariate analysis. In patients with heavy tumour load in bone and great bone pain, the percentage of SREs was almost twice as high as (26 vs 52%, P<0.02) and occurred significantly earlier (P=0.000) than SREs in patients with limited DE in bone and low pain. Bone pain and DE in bone independently predict the occurrence of SREs in bone metastatic prostate cancer patients with hormone-refractory disease. These findings could help physicians in tailoring the skeletal follow-up most appropriate to individual patients and may prove useful for stratifying patients enrolled in bisphosphonate clinical trials
V24 Sequential trans-urethral resection of prostate and laparoscopic bladder diverticulectomy under us guidance
Transperitoneal versus extraperitoneal laparoscopic radical prostatectomy: experience of a single center
Is laparoscopic bladder diverticulectomy after transurethral resection of the prostate safe and effective? Comparison with open surgery
Is laparoscopic bladder diverticulectomy after transurethral resection of the prostate safe and effective? Comparison with open surgery
Sequential transurethral resection of the prostate and laparoscopic bladder diverticulectomy: comparison with open surgery.
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