A. Volpe

C. Terrone

E. De Lorenzis

G. Marchioro

M. Vidali

M. Zacchero

P. De Angelis

R. Tarabuzzi

English

Giansilvio Marchioro

Alessandro Volpe

Roberto Tarabuzzi

Matteo Vidali

Monica Zacchero

Paolo De Angelis

Elisa De Lorenzis

Carlo Terrone

AIR Universita degli studi di Milano

followed. Results: 24.32% of patients with hematuria werefound to have a bladder cancer; 20.78% had a urinary stone;1.18% had prostate cancer; 1.18% had a renal cell carcinoma;0.39 had a urachus neoplasm. The mean age was 68.6 yrs.5.8% of the patients (24.2% on patients with TCC of thebladder) had a G3 disease. The mean time from admission tothe HOSC until the operation day, in case of TCC of thebladder, was 11.1 days. The mean access time to HOSC sincethe event of haematuria was 3.88 days. The patient averagesatisfaction level, for those referred to the HOSC, was 4.5 (ona scale from 1 to 5). Conclusion: The Italian experience of theOne Stop Clinic confirms a high rate of bladder cancerdetection. Furthermore, a high rate of non-malignantconditions was detected, stressing the importance of theHOSC not only as a cancer clinic but as a complete generalurological clinic. We report a shorter waiting time tooperation, especially for bladder TCC G3 patients. It shouldbe a mission of all urologists who manage this disease toensure that timely and evidence-based treatment is availableto all patients; this should include education of referringproviders within their community about bladder cancerawareness and the importance of timely referral for evaluationof haematuria. 145SERUM LEVELS OF ANGIOGENETIC CANCER BIOMARKERS IN MEN UNDERGOINGPROSTATE BIOPSY. PRELIMINARY DATAGiuseppe Bronte1, Stefano Caruso1, Marianna Terrasi1, Dario Passalacqua2, Nino Dispensa2, Vincenzo Serretta2,Carlo Pavone2, Antonio Russo11Oncologia Medica, Dipartimento Discipline Chirurgiche edOncologiche Università di Palermo; 2Urologia Dipartimento Materno-Infantile, Andrologia eUrologia, Università di Palermo, ItalyBackground: The reduction of the number of negative prostatebiopsies in patients with elevated serum PSA represents amajor challenge. Several angiogenetic biomarkers are involvedin carcinogenesis and cancer progression. The aim of ourpreliminary study was to investigate if their serum levels mightbe related to prostate cancer detection. Patients and Methods:Angiopoietin 2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1, VEGF, PTH were the selected biomarkers forour research. They were measured by BioPlex immunoassay.As a preliminary step, consecutive unselected patientsundergoing prostate biopsy for palpable prostate nodule and/orelevated PSA levels were entered. A 12-core transrectal biopsywas planned. The serum levels of the above mentionedbiomarkers were related with the histological result of thebiopsy. ROC curve analysis was exploited to test thediagnostic accuracy of each biomarker by AUC calculation. Apotential cut-off level was computed for each biomarker.Results: Thirty-five consecutive patients were entered in thispreliminary study. The median PSA was 6.3 ng/ml (mean:19.4, range 0.41-364). An altered prostate was found at digitalrectal examination in 13 (37%) patients. Transrectal ultrasoundgave a median prostate volume of 44.5 cc (mean 48.7; range15-105cc). Seven patients (20%) had a previous negativebiopsy and 5 were receiving dutasteride or finasteride. Amedian number of 12 biopsy cores was obtained (mean: 12range 4-24). Prostate cancer was detected in 21 (60%) men.ASAP and PIN were detected in 2 more patients respectively.Among the 9 considered angiogenetic biomarkers, only leptinpreliminarily shows an interesting diagnostic accuracy with anAUC of 0,714 (Table 1). At a cut-off value of 2166 pg/ml,leptin demonstrates a sensitivity of 74% and a specificity of75% with a positive predictive value of 85%. Conclusion:Only leptin, among the 9 studied biomarkers, showedpromising diagnostic accuracy for the detection of prostatecancer, suggesting the usefulness of further research. Table I. ROC curve analysis (AUC).Angiogenetic biomarker AUCAngiopoietin_2 0.511Follistatin 0.676G-CSF 0.658HGF 0.636IL-8 0.524Leptin 0.714PDGF-BB 0.638PECAM-1 0.596VEGF 0.589146RADICAL PROSTATECTOMY FOR PATIENTS WITH CLINICALLY LOCALLY ADVANCEDPROSTATE CANCER: RESULTS OF A SINGLE INSTITUTIONAL STUDYGiansilvio Marchioro1, Alessandro Volpe1, Roberto Tarabuzzi1, Matteo Vidali2, Monica Zacchero1,Paolo De Angelis1, Elisa De Lorenzis1, Carlo Terrone11Department of Urology, 2Department of Clinical Chemistry,Maggiore della Carità Hospital, University of EasternPiedmont, ItalyIntroduction: Aim of this study was to report the outcomes ofa single institution study on 98 pts with clinically locallyadvanced prostate cancer (PCa) and prostate specific antigenAbstracts of the 22nd Annual Meeting of the Italian Society of Uro-Oncology (SIUrO), 13-15 June, 2012, Bologna, Italy1935

RADICAL PROSTATECTOMY FOR PATIENTS WITH CLINICALLY LOCALLY ADVANCED PROSTATE CANCER: RESULTS OF A SINGLE INSTITUTIONAL STUDY

https://air.unimi.it/bitstream/2434/737178/2/14636SIURO..pdf

RADICAL PROSTATECTOMY FOR PATIENTS WITH CLINICALLY LOCALLY ADVANCED PROSTATE CANCER: RESULTS OF A SINGLE INSTITUTIONAL STUDY

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