Cell–cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction [version 1; referees: 2 approved]

The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell–cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell–cell adhesion interface

Searching for Intermediate Mass Black Holes in Globular Clusters Through Tidal Disruption Events

Intermediate mass black holes (IMBHs) may be the link between stellar mass holes and the supermassive variety in the nuclei of galaxies, and globular clusters (GCs) may be one of the most promising environments for their formation. Here we carry out a pilot study of the observability of tidal disruption events (TDEs) from 10^3 Msun < M_BH < 10^5 Msun IMBHs embedded in stellar cusps at the center of GCs. We model the long super-Eddington accretion phase and ensuing optical flare, and derive the disruption rate of main-sequence stars as a function of black hole mass and GC properties with the help of a 1D Fokker-Planck approach. The photospheric emission of the adiabatically expanding outflow dominates the observable radiation and peaks in the NUV/optical bands, outshining the brightness of the (old) stellar population of GCs in Virgo for a period of months to years. A search for TDE events in a sample of nearly 4,000 GCs observed at multiple epochs by the Next Generation Virgo Cluster Survey (NGVS) yields null results. Given our model predictions, this sample is too small to set stringent constraints on the present-day occupation fraction of GCs hosting IMBHs. Naturally, better simulations of the properties of the cluster central stellar distribution, TDE light curves and rates, together with larger surveys of GCs are all needed to gain deeper insights into the presence of IMBHs in GCs.Comment: 12 pages, 9 figures, submitted for publication in The Astrophysical Journa

Applying Machine Learning to Crowd-sourced Data from Earthquake Detective

We present the Earthquake Detective dataset - A crowdsourced set of labels on potentially triggered (PT) earthquakes and tremors. These events are those which may have been triggered by large magnitude and often distant earthquakes. We apply Machine Learning to classify these PT seismic events and explore the challenges faced in segregating such low amplitude signals. The data set and code are available online.Comment: Published in AI for Earth Sciences Workshop, NeurIPS 202

Advanced progress in recycling municipal and construction solid wastes for manufacturing sustainable construction materials

The sharply increasing solid waste generation has raised the environmental concerns worldwide which currently have been escalated to a worrying level. Intending to eliminate the negative environmental impacts of solid waste and meanwhile promote sustainability on the energy- and resource-intensive construction and building sector, considerable efforts have been devoted to recycling solid waste for the possible use in sustainable construction material products. This paper reviews the existing studies on recycling municipal and construction solid waste for the manufacture of geopolymer composites. Special attention is paid to the predominate performance of these geopolymer composite products. The principal findings of this work reveal that municipal and construction solid waste could be successfully incorporated into geopolymer composites in the forms of precursor, aggregate, additive, reinforcement fiber, or filling material. Additionally, the results indicate that although the inclusion of such waste might depress some of the attributes of geopolymer composites, proper proportion design and suitable treatment technique could alleviate these detrimental effects and further smooth the recycling progress. Finally, a brief discussion is provided to identify the important needs in the future research and development for promoting the utilization of solid waste materials in the forthcoming sustainable geopolymer industry. In summary, this work offers guidance for the better ecological choice to municipal and construction solid waste through developing waste materials into highly environmental-friendly construction materials

Synergistic effects of polypropylene and glass fiber on mechanical properties and durability of recycled aggregate concrete

To better understand the synergistic effects of combined fibers on mechanical properties and durability of recycled aggregate concrete (RAC), different types of fibers with various lengths and mass ratios were adopted in this study. Experimental investigations were conducted to study the 28-day compressive strength and strength loss after exposed to salt-solution freeze–thaw cycles and the coupled action of mechanical loading and salt-solution freeze–thaw cycles. The microstructure was also characterized to evaluate the mechanism of this synergistic effect. To determine the effectiveness of the combined fibers on improving the mechanical properties and durability of RAC, the synergistic coefficient was proposed and applied for various combinations of fibers. The results indicate that the incorporation of fibers slightly decreased the 28-day compressive strength of RAC, but combining different sizes and types of fibers can mitigate this negative effect. Moreover, the incorporation of fibers greatly improves the freeze–thaw resistance of RAC. The combining different fibers exhibited a synergistic effect on the enhancement in properties of RAC, which could not be predicted with only one simplistic rule of fibre mixtures. In addition, microstructural characterization shows that the bonding strength of the interfacial transition zone (ITZ) between the fiber and cement matrix is mainly determined by the chemical bonding force which is due to the hydration reaction between fiber surface and cement matrix

Myogenin regulates denervation‐dependent muscle atrophy in mouse soleus muscle

Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy‐related genes, like Atrogin‐1 and MuRF‐1, are intimately tied to loss of muscle mass. When these atrophy‐related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle‐specific transcription factor that is highly induced following muscle denervation. To investigate if Myog contributes to muscle atrophy, we have taken advantage of conditional Myog null mice. We show that in the denervated soleus muscle Myog expression contributes to reduced muscle force, mass, and cross‐sectional area. We found that Myog mediates these effects, at least in part, by regulating expression of the Atrogin‐1 and MuRF‐1 genes. Indeed Myog over‐expression in innervated muscle stimulates Atrogin‐1 gene expression and Myog over‐expression stimulates Atrogin‐1 promoter activity. Thus, Myog and the signaling cascades regulating its induction following muscle denervation may represent novel targets for therapies aimed at reducing denervation‐induced muscle atrophy. J. Cell. Biochem. 112: 2149–2159, 2011. © 2011 Wiley‐Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86926/1/23136_ftp.pd

House dust mites possess a polymorphic, single domain putative peptidoglycan d,l endopeptidase belonging to the NlpC/P60 Superfamily

AbstractA 14kDa protein homologous to the γ-d-glutamyl-l-diamino acid endopeptidase members of the NlpC/P60 Superfamily has been described in Dermatophagoides pteronyssinus and Dermatophagoides farinae but it is not clear whether other species produce homologues. Bioinformatics revealed homologous genes in other Sarcopteformes mite species (Psoroptes ovis and Blomia tropicalis) but not in Tetranychus urticae and Metaseiulus occidentalis. The degrees of identity (similarity) between the D. pteronyssinus mature protein and those from D. farinae, P. ovis and B. tropicalis were 82% (96%), 77% (93%) and 61% (82%), respectively. Phylogenetic studies showed the mite proteins were monophyletic and shared a common ancestor with both actinomycetes and ascomycetes. The gene encoding the D. pteronyssinus protein was polymorphic and intronless in contrast to that reported for D. farinae. Homology studies suggest that the mite, ascomycete and actinomycete proteins are involved in the catalysis of stem peptide attached to peptidoglycan. The finding of a gene encoding a P60 family member in the D. pteronyssinus genome together with the presence of a bacterial promotor suggests an evolutionary link to one or more prokaryotic endosymbionts