Selective Attention and Audiovisual Integration: Is Attending to Both Modalities a Prerequisite for Early Integration?

Interactions between multisensory integration and attention were studied using a combined audiovisual streaming design and a rapid serial visual presentation paradigm. Event-related potentials (ERPs) following audiovisual objects (AV) were compared with the sum of the ERPs following auditory (A) and visual objects (V). Integration processes were expressed as the difference between these AV and (A + V) responses and were studied while attention was directed to one or both modalities or directed elsewhere. Results show that multisensory integration effects depend on the multisensory objects being fully attended—that is, when both the visual and auditory senses were attended. In this condition, a superadditive audiovisual integration effect was observed on the P50 component. When unattended, this effect was reversed; the P50 components of multisensory ERPs were smaller than the unisensory sum. Additionally, we found an enhanced late frontal negativity when subjects attended the visual component of a multisensory object. This effect, bearing a strong resemblance to the auditory processing negativity, appeared to reflect late attention-related processing that had spread to encompass the auditory component of the multisensory object. In conclusion, our results shed new light on how the brain processes multisensory auditory and visual information, including how attention modulates multisensory integration processes

A retinotopic attentional trace after saccadic eye movements: evidence from event-related potentials

Saccadic eye movements are a major source of disruption to visual stability, yet we experience little of this disruption. We can keep track of the same object across multiple saccades. It is generally assumed that visual stability is due to the process of remapping, in which retinotopically organized maps are updated to compensate for the retinal shifts caused by eye movements. Recent behavioral and ERP evidence suggests that visual attention is also remapped, but that it may still leave a residual retinotopic trace immediately after a saccade. The current study was designed to further examine electrophysiological evidence for such a retinotopic trace by recording ERPs elicited by stimuli that were presented immediately after a saccade (80 msec SOA). Participants were required to maintain attention at a specific location (and to memorize this location) while making a saccadic eye movement. Immediately after the saccade, a visual stimulus was briefly presented at either the attended location (the same spatiotopic location), a location that matched the attended location retinotopically (the same retinotopic location), or one of two control locations. ERP data revealed an enhanced P1 amplitude for the stimulus presented at the retinotopically matched location, but a significant attenuation for probes presented at the original attended location. These results are consistent with the hypothesis that visuospatial attention lingers in retinotopic coordinates immediately following gaze shifts

Inducing ferromagnetism and Kondo effect in platinum by paramagnetic ionic gating

Electrically controllable magnetism, which requires the field-effect manipulation of both charge and spin degrees of freedom, has attracted growing interests since the emergence of spintronics. In this work, we report the reversible electrical switching of ferromagnetic (FM) states in platinum (Pt) thin films by introducing paramagnetic ionic liquid (PIL) as the gating media. The paramagnetic ionic gating controls the movement of ions with magnetic moments, which induces itinerant ferromagnetism on the surface of Pt films with large coercivity and perpendicular anisotropy mimicking the ideal two-dimensional Ising-type FM state. The electrical transport of the induced FM state shows Kondo effect at low temperature suggesting spatially separated coexistence of Kondo scattering beneath the FM interface. The tunable FM state indicates that paramagnetic ionic gating could serve as a versatile method to induce rich transport phenomena combining field effect and magnetism at PIL-gated interfaces.Comment: 17 pages, 4 figure

Sensitivity and Partitioning in Remote Sensing Based Evapotranspiration Models

Satellite Based evapotranspiration (ET) models have become a dominant means to estimate large-scale surface fluxes of water. Global and regional ET estimates are important parameters in many climate forecasts and hydrologic models. However, large scale partitioning of ET into soil evaporation, transpiration, and canopy interceptions remains largely unknown and modeled estimates have been shown to diverge strongly. This study examines three such remote sensing-based models: the Penman-Monteith model from the Moderate Resolution Imaging Spectroradiometer (PM-MOD), the Priestley-Taylor Jet Propulsion Laboratory model (PT-JPL), and the Global Land Evaporation Amsterdam Model (GLEAM). Modeled ET and component estimates are compared against a compiled dataset of field estimates using stable isotopes, sap flux, and other methods. Results are analyzed across land cover type, precipitation regime, and field methods. Overall, we find large deviations between field and modeled estimates of soil evaporation (RMSD = 90-114%, r2 = 0.14-0.25, N = 35), interception (RMSD = 62-181%, r2 = 0.39-0.85, N = 13), and transpiration (RMSD = 54–114%, r2 = 0.33-0.55, N = 35) compared to the deviations found in the total ET estimate (RMSD = 35-49%, r2 = 0.61-0.75, N = 35). We then conduct a Monte Carlo sensitivity analysis using varying degrees of parameter uncertainty to determine how forcing data error influences model estimates and to determine which parameters are the primary drivers of each model. We find large sensitivity and bias in component estimates that becomes mitigated when aggregated into a total ET estimate. The results also show that the total ET of PT-JPL, PM-MOD, and GLEAM is most sensitive to NDVI, RH, and net radiation, respectively. The results of each study suggest that the soil evaporation component exhibits large errors and may be culpable for errors in ET partitioning. These results suggest that future improvements to remote sensing-based ET component estimates will vastly improve the confidence of the total ET estimates and provide greater understanding in how water interacts with vegetation, climate, and society

Time to positivity of acute and chronic periprosthetic joint infection cultures

Introduction: A prolonged incubation time is generally recommended for diagnosing periprosthetic joint infections (PJI). However, in literature, no distinction is made between acute and chronic infections. Methods: All patients with a PJI that underwent surgical debridement between November 2015 and February 2019 with or without revision of the prosthesis were retrospectively evaluated. Synovial fluid, 5 intraoperative periprosthetic tissue samples, and the sonicated prosthesis were cultured. Results: Fifty-nine patients were analyzed, including 21 acute PJIs (33 isolates) and 38 chronic PJIs (46 isolates). In acute PJIs, all isolates grew within 5 days, while this took 11 days for chronic PJIs. Sonication fluid showed the shortest time to positivity (78% at day 2) for chronic PJIs, but no difference was observed for acute PJIs compared to tissue cultures. Conclusion: In contrast to cultures from chronic PJIs, acute PJIs do not need a prolonged incubation time and no clear benefit is observed for sonication. (C) 2020 The Authors. Published by Elsevier Inc

Potential of model predictive control of a polder water system including pumps, weirs and gates

This work presents an assessment of the potential of model predictive control (MPC) of a Dutch polder system. The system drains to the Linge river and includes 13 weirs, 4 hydraulic gates and 4 large pumping stations each equipped with multiple pumps, managed by the Water Board Rivierenland. The management of the system must comply with several goals: keep the water levels within the bounds of safety, pump out the excess water at minimum cost or CO2 emission, but always have enough water for irrigation and shipping. To achieve these goals there are weirs regulating the water level in different pools, pumping stations to pump water in and out and gates to let water in and out by free flow when possible. These pumping stations consume large amounts of energy. We propose multi-objective mixed-integer optimization by using goal programming to prioritize different operational objectives. For the control of the pumps mixed-integer optimization is used, which makes it possible to not only model the energy consumption of the pumps while in operation, but also to model if the pumps are turned on or off. The control system is implemented using RTC-Tools, an open-source software tool to implement MPC. It is demonstrated that the proposed control system implementation can comply with the operational goals of the water board: keeping the water levels within the bounds while reducing the operational costs. The proposed control system has been tested numerically on data from the year 2013, and it is shown that it highly outperforms the current operation.</p

Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient:a systematic review

This article systematically reviews the literature on the impact of collaboration between pharmacists and general practitioners and describes its effect on patients' health. A systematic literature search provided 1041 articles. After first review of title and abstract, 152 articles remained. After review of the full text, 83 articles were included. All included articles are presented according to the following variables: (i) reference; (ii) design and setting of the study; (iii) inclusion criteria for patients; (iv) description of the intervention; (v) whether a patient interview was performed to involve patients' experiences with their medicine-taking behaviour; (vi) outcome; (vii) whether healthcare professionals received additional training; and (viii) whether healthcare professionals received financial reimbursement. Many different interventions are described where pharmacists and general practitioners work together to improve patients' health. Only nine studies reported hard outcomes, such as hospital (re)admissions; however, these studies had different results, not all of which were statistically significant. Randomized controlled trials should be able to describe hard outcomes, but large patient groups will be needed to perform such studies. Patient involvement is important for long-term success

Intermodal attention affects the processing of the temporal alignment of audiovisual stimuli

The temporal asynchrony between inputs to different sensory modalities has been shown to be a critical factor influencing the interaction between such inputs. We used scalp-recorded event-related potentials (ERPs) to investigate the effects of attention on the processing of audiovisual multisensory stimuli as the temporal asynchrony between the auditory and visual inputs varied across the audiovisual integration window (i.e., up to 125 ms). Randomized streams of unisensory auditory stimuli, unisensory visual stimuli, and audiovisual stimuli (consisting of the temporally proximal presentation of the visual and auditory stimulus components) were presented centrally while participants attended to either the auditory or the visual modality to detect occasional target stimuli in that modality. ERPs elicited by each of the contributing sensory modalities were extracted by signal processing techniques from the combined ERP waveforms elicited by the multisensory stimuli. This was done for each of the five different 50-ms subranges of stimulus onset asynchrony (SOA: e.g., V precedes A by 125–75 ms, by 75–25 ms, etc.). The extracted ERPs for the visual inputs of the multisensory stimuli were compared among each other and with the ERPs to the unisensory visual control stimuli, separately when attention was directed to the visual or to the auditory modality. The results showed that the attention effects on the right-hemisphere visual P1 was largest when auditory and visual stimuli were temporally aligned. In contrast, the N1 attention effect was smallest at this latency, suggesting that attention may play a role in the processing of the relative temporal alignment of the constituent parts of multisensory stimuli. At longer latencies an occipital selection negativity for the attended versus unattended visual stimuli was also observed, but this effect did not vary as a function of SOA, suggesting that by that latency a stable representation of the auditory and visual stimulus components has been established

Stay Tuned: What Is Special About Not Shifting Attention?

Background: When studying attentional orienting processes, brain activity elicited by symbolic cue is usually compared to a neutral condition in which no information is provided about the upcoming target location. It is generally assumed that when a neutral cue is provided, participants do not shift their attention. The present study sought to validate this assumption. We further investigated whether anticipated task demands had an impact on brain activity related to processing symbolic cues. Methodology/Principal Findings: Two experiments were conducted, during which event-related potentials were elicited by symbolic cues that instructed participants to shift their attention to a particular location on a computer screen. In Experiment 1, attention shift-inducing cues were compared to non-informative cues, while in both conditions participants were required to detect target stimuli that were subsequently presented at peripheral locations. In Experiment 2, a non-ambiguous "stay-central'' cue that explicitly required participants not to shift their attention was used instead. In the latter case, target stimuli that followed a stay-central cue were also presented at a central location. Both experiments revealed enlarged early latency contralateral ERP components to shift-inducing cues compared to those elicited by either non-informative (exp. 1) or stay-central cues (exp. 2). In addition, cueing effects were modulated by the anticipated difficulty of the upcoming target, particularly so in Experiment 2. A positive difference, predominantly over the posterior contralateral scalp areas, could be observed for stay-central cues, especially for those predicting that the upcoming target would be easy. This effect was not present for non-informative cues. Conclusions/Significance: We interpret our result in terms of a more rapid engagement of attention occurring in the presence of a more predictive instruction (i.e. stay-central easy target). Our results indicate that the human brain is capable of very rapidly identifying the difference between different types of instructions

Sensitivity of evapotranspiration components in remote sensing-based models

Accurately estimating evapotranspiration (ET) at large spatial scales is essential to our understanding of land-atmosphere coupling and the surface balance of water and energy. Comparisons between remote sensing-based ET models are difficult due to diversity in model formulation, parametrization and data requirements. The constituent components of ET have been shown to deviate substantially among models as well as between models and field estimates. This study analyses the sensitivity of three global ET remote sensing models in an attempt to isolate the error associated with forcing uncertainty and reveal the underlying variables driving the model components. We examine the transpiration, soil evaporation, interception and total ET estimates of the Penman-Monteith model from the Moderate Resolution Imaging Spectroradiometer (PM-MOD), the Priestley-Taylor Jet Propulsion Laboratory model (PT-JPL) and the Global Land Evaporation Amsterdam Model (GLEAM) at 42 sites where ET components have been measured using field techniques. We analyse the sensitivity of the models based on the uncertainty of the input variables and as a function of the raw value of the variables themselves. We find that, at 10% added uncertainty levels, the total ET estimates from PT-JPL, PM-MOD and GLEAM are most sensitive to Normalized Difference Vegetation Index (NDVI) (%RMSD = 100.0), relative humidity (%RMSD = 122.3) and net radiation (%RMSD = 7.49), respectively. Consistently, systemic bias introduced by forcing uncertainty in the component estimates is mitigated when components are aggregated to a total ET estimate. These results suggest that slight changes to forcing may result in outsized variation in ET partitioning and relatively smaller changes to the total ET estimates. Our results help to explain why model estimates of total ET perform relatively well despite large inter-model divergence in the individual ET component estimates