Choriocarcinoma coexisting with epithelioid trophoblastic tumor of the uterine horn

• We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor. • Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious. • Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy

テンシャ インシ Stat3 オ カイシタ ランソウガン サイボウ ト マクロファージ ト ノ サイボウカン ソウゴ サヨウ

マクロファージは正常ヒト腹腔内に常在し、腹腔内における免疫機能の中心的役割を担っている。マクロファージは、その活性化状態によって、抗腫瘍活性を示すM1マクロファージと腫瘍増殖を促進するM2マクロファージに二大別されるが、腹腔マクロファージの、腹腔内環境によってM1マクロファージあるいはM2マクロファージに分化することが報告されている。多量の腹水貯留と腹腔内播種をきたす進行卵巣癌においては、腹水中でマクロファージが増加していることが既に知られている。しかし、進行卵巣癌細胞とマクロファージの相互関連については、十分に明らかとなっていない。私は、進行卵巣癌腹水中におけるマクロファージの分化と、それに関与するsignal transducer and activator of transcription 3 (Stat3) の活性化について解析を加えるとともに、マクロファージが癌細胞増殖に及ぼす影響について検討を加えた。Ascites macrophages in advanced epithelial ovarian cancer are involved in cancer metastasis and progression by modifying the tumor microenvironment. However, the precise mechanisms of cell-to-cell interaction between macrophages and tumor cells are still unclear. This study focused on the activation of signal transducer and activator of transcription 3 (Stat3) which is a critical signal transduction molecule at a point of convergence for numerous oncogenic signaling pathways as well as controlling the M2-poralization of macrophages

Pancreatic Metastasis from Mixed Adenoneuroendocrine Carcinoma of the Uterine Cervix: A Case Report

Metastatic cancers of the pancreas are rare, accounting for approximately 2-4% of all pancreatic malignancies. Renal cell carcinoma is the most common solid tumor that metastasizes to the pancreas. Here, we present a case of uterine cervical carcinoma metastasizing to the pancreas and review the literature regarding this rare event. A 44-year-old woman with a uterine cervical tumor had undergone radical hysterectomy and had been diagnosed pathologically with stage Ib mixed adenoneuroendocrine carcinoma in 2004. She underwent concurrent radiotherapy and chemotherapy postoperatively. Pulmonary metastases subsequently appeared in 2008 and 2011, and she underwent complete resection of the lung tumors by video-assisted thoracic surgery. Although she was followed up without any treatment and with no other recurrences, positron emission tomography revealed an area of abnormal uptake within the pancreatic body in 2012. Enhanced computed tomography demonstrated a 20-mm lesion in the pancreatic body and upstream pancreatic duct dilatation. Endoscopic ultrasonography-guided fine needle aspiration was performed and pathological examination suggested neuroendocrine carcinoma (NEC). On the basis of these results and the patient's oncological background, lesions in the pancreatic body were diagnosed as secondary metastasis from the cervical carcinoma that had been treated 8 years earlier. No other distant metastases were visualized, and the patient subsequently underwent middle pancreatectomy. Pathological examination showed NEC consistent with pancreatic metastasis from the uterine cervical carcinoma. The patient has survived 7 months since the middle pancreatectomy without any signs of local recurrence or other metastatic lesions