Squamous Cell Carcinoma Developing in a Buccal Mucosa Graft after Urethroplasty: A Report of 2 Cases of Malignant Degeneration

Buccal mucosa graft (BMG) was originally described in 1992 for the treatment of challenging cases of hypospadias (proximal or redo cases) and has gained increasingly popularity also when dealing with complicated urethral stenosis, as it is associated with a good outcome. The development of a malignancy in a BMG urethroplasty was reported for the first time in 2017. We report two more cases of a malignant degeneration of a BMG used in a urethroplasty to treat recurrent urethral stricture

Higher order photoprotection mutants reveal the importance of \u394pH-dependent photosynthesis-control in preventing light induced damage to both photosystem II and photosystem I

Although light is essential for photosynthesis, when in excess, it may damage the photosynthetic apparatus, leading to a phenomenon known as photoinhibition. Photoinhibition was thought as a light-induced damage to photosystem II; however, it is now clear that even photosystem I may become very vulnerable to light. One main characteristic of light induced damage to photosystem II (PSII) is the increased turnover of the reaction center protein, D1: when rate of degradation exceeds the rate of synthesis, loss of PSII activity is observed. With respect to photosystem I (PSI), an excess of electrons, instead of an excess of light, may be very dangerous. Plants possess a number of mechanisms able to prevent, or limit, such damages by safe thermal dissipation of light energy (non-photochemical quenching, NPQ), slowing-down of electron transfer through the intersystem transport chain (photosynthesis-control, PSC) in co-operation with the Proton Gradient Regulation (PGR) proteins, PGR5 and PGRL1, collectively called as short-term photoprotection mechanisms, and the redistribution of light between photosystems, called state transitions (responsible of fluorescence quenching at PSII, qT), is superimposed to these short term photoprotective mechanisms. In this manuscript we have generated a number of higher order mutants by crossing genotypes carrying defects in each of the short-term photoprotection mechanisms, with the final aim to obtain a direct comparison of their role and efficiency in photoprotection. We found that mutants carrying a defect in the \u394pH-dependent photosynthesis-control are characterized by photoinhibition of both photosystems, irrespectively of whether PSBS-dependent NPQ or state transitions defects were present or not in the same individual, demonstrating the primary role of PSC in photoprotection. Moreover, mutants with a limited capability to develop a strong PSBS-dependent NPQ, were characterized by a high turnover of the D1 protein and high values of Y(NO), which might reflect energy quenching processes occurring within the PSII reaction center

Higher order photoprotection mutants reveal the importance of ΔpH-dependent photosynthesis-control in preventing light induced damage to both photosystem II and photosystem I

Although light is essential for photosynthesis, when in excess, it may damage the photosynthetic apparatus, leading to a phenomenon known as photoinhibition. Photoinhibition was thought as a light-induced damage to photosystem II; however, it is now clear that even photosystem I may become very vulnerable to light. One main characteristic of light induced damage to photosystem II (PSII) is the increased turnover of the reaction center protein, D1: when rate of degradation exceeds the rate of synthesis, loss of PSII activity is observed. With respect to photosystem I (PSI), an excess of electrons, instead of an excess of light, may be very dangerous. Plants possess a number of mechanisms able to prevent, or limit, such damages by safe thermal dissipation of light energy (non-photochemical quenching, NPQ), slowing-down of electron transfer through the intersystem transport chain (photosynthesis-control, PSC) in co-operation with the Proton Gradient Regulation (PGR) proteins, PGR5 and PGRL1, collectively called as short-term photoprotection mechanisms, and the redistribution of light between photosystems, called state transitions (responsible of fluorescence quenching at PSII, qT), is superimposed to these short term photoprotective mechanisms. In this manuscript we have generated a number of higher order mutants by crossing genotypes carrying defects in each of the short-term photoprotection mechanisms, with the final aim to obtain a direct comparison of their role and efficiency in photoprotection. We found that mutants carrying a defect in the ΔpH-dependent photosynthesis-control are characterized by photoinhibition of both photosystems, irrespectively of whether PSBS-dependent NPQ or state transitions defects were present or not in the same individual, demonstrating the primary role of PSC in photoprotection. Moreover, mutants with a limited capability to develop a strong PSBS-dependent NPQ, were characterized by a high turnover of the D1 protein and high values of Y(NO), which might reflect energy quenching processes occurring within the PSII reaction center.</p

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

The use of historical cartography and ALS technology to map the geomorphological changes of volcanic areas: A case study from Gran Cono of Somma-Vesuvius volcano

Co-auteur étranger ; This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.International audienceThe eruptive activity of a volcano modifies its surface topography through morphological changes generated by the deposition of emitted volcanic material and resulting gravity-driven processes, which can form accumulation of material in addition to the most common erosional phenomena. Mapping and quantifying such morphological changes allow to derive new data useful to better describe and understand the eruptive history of the volcano itself. Nowadays, one of the mostly used method to identify such morphological changes consists of comparing Digital Elevation Models (DEM) of the volcanic area before and after an eruptive event. If the eruptive event is referred to periods prior to 1980's, the only method to reproduce DEMs consists of elaborating the historical cartography that is often available only in paper format. In this work we aim to prove the reliability of this approach, presenting a study on the morphological changes (from 1876 to 1944) of the summit caldera of the Somma–Vesuvio volcano (Italy). For the first time, we compare DEMs derived from historical maps (1876, 1906 and 1929) and a DEM dated 2012 obtained by remote sensing. The four models of the caldera, digitally reproduced at the same spatial resolution, are morphologically investigated through specific maps derived from the DEMs and a set of height profiles. In addition, further morphometric analyses and accurate quantifications in volume and surface are presented and discussed for a portion of the Somma-Vesuvio summit caldera, represented by the Gran Cono edifice. Considering the different typology of the source data used in this study, it is also provided a discussion on the respective accuracies that, especially for the historical maps, represent a crucial point for obtaining DEMs able to reproduce topographies more realistic as possible. For this reason, despite data source were processed following rigours criteria, the calculations of volume, surface and distance related to the morphological changes of the volcano are associated to an accurate quantification of the error. Following this, the main results obtained in this study are: i) the identification of several past volcanic deposits and the estimation of the related thicknesses, both in good agreement with published literature; ii) the quantification of the morphological changes of the Gran Cono from 1876 to 1944 resulting in a volume and surface growth of 133 × 106 m3 (±5%) and ~0.14 km2, respectively; iii) the identification of a possible migration path of the centroid of the Gran Cono crater along the SW-NE preferential direction during the investigated period

Volcanoclastic flow hazard assessment in highly populated areas: a GIS-based approach applied to Torre del Greco municipality (Somma-Vesuvius, Italy)

This paper presents a contribution to Volcanoclastic Flows hazard assessment in very densely populated volcanic areas by using a multidisciplinary study applied to the Torre del Greco area, a municipality close to the active Somma-Vesuvius volcano, in Italy. This study integrates and combines in a GIS environment several types of data: i) information on Volcanoclastic Flows recorded during the years 1906â\u80\u932010, derived from historical chronicles and local reports; ii) rainfall data relative to the investigated period; iii) summary of the recent activity of Somma-Vesuvius (AD 1631â\u80\u93AD 1944) deriving from the scientific literature; iv) morphological and morphometric analyses derived from a very high resolution Digital Elevation Model developed in the years 2009â\u80\u932012. The historical analysis of the spatial and temporal distribution of the Volcanoclastic Flows recorded in the Vesuvian area during the last 104 years indicates that the zone mostly affected by such phenomena is the south-western sector of Somma-Vesuvius, and in particular the Torre del Greco municipality, for which a specific database on paths and directions of the historical Volcanoclastic Flows was implemented. The analysis and comparison of all available data allowed us to: i) recognize that the source zone of Volcanoclastic Flows occurred in Torre del Greco was a funnel-shaped area located immediately SW of the Somma-Vesuvius caldera boundary and just above the most urbanized area of the town; ii) individuate the key morphometric parameters (slope and curvature) necessary for the potential triggering of Volcanoclastic Flows; and iii) investigate possible relationships between the fallout deposits of the Somma-Vesuvius main recent eruptions and the historical Volcanoclastic Flows of Torre del Greco. Although this approach represents only a starting point for studies aimed at the assessment and mitigation of Volcanoclastic Flows hazard, it can be applied in other volcanic zones having similar characteristics to the Somma-Vesuvius area. Moreover, it can be used not only during a period of volcanic quiescence when heavy and/or persistent rains are able to remobilize loose pyroclastic deposits, but also in syn-eruptive conditions

Monitoring of Eruptive Products: Pyroclastic Density Currents and their Deposits

International audienc

Monitoring of Eruptive Products: Pyroclastic Density Currents and their Deposits

International audienc

Particle Sedimentation in Numerical Modelling: A Case Study from the Puyehue-Cordón Caulle 2011 Eruption with the PLUME-MoM/HYSPLIT Models

International audienceNumerical modelling of tephra fallout is a fast-developing research area in volcanology. Several models are currently available both to forecast the dispersion of volcanic particles in the atmosphere and to calculate the particles deposited at different locations on the ground. Data from these simulations can then be used both to manage volcanic crises (e.g., protect air traffic) or perform long-term hazard assessment studies (e.g., through hazard maps). Given the importance of these tasks, it is important that each model is thoroughly tested in order to assess advantages and limitations, and to provide useful information for quantifying the model uncertainty. In this study we tested the coupled PLUME-MoM/HYSPLIT models by applying them to the Puyehue–Cordon Caulle 2011 sub-Plinian eruption. More specifically, we tested new features recently introduced in these well-established models (ash aggregation, external water addition, and settling velocity models), we implemented a new inversion procedure, and we performed a parametric analysis. Our main results reaffirm the pivotal role played by mass eruption rate on the final deposit and show that some choices for the input parameters of the model can lead to the large overestimation in total deposited mass (which can be reduced with our inversion procedure). The parametric analysis suggests a most likely value of the mass eruption rate in the range 2.0–6.3 × 106 kg/s. More studies with a similar approach would be advisable in order to provide final users with useful indications about the parameters that should be carefully evaluated before being used as input for this kind of model