42,733 research outputs found
Squeeze-film gas bearing technology
Squeeze-film bearing is studied to develop a low-friction suspension for the output-axis gimbal of a single-degree-of-freedom gyroscope. Included are a review of pertinent literature, the theory of squeeze-film lubrication, and design elements
On Error Torques of Squeeze-film Cylindrical Journal Bearings
Error torques of squeeze film cylindrical journal bearing
Competitive Pressure on China: Factor Rewards Migration
Our objective is to assess personal income under perfect competition, when factors are rewarded according to their productivities, and to contrast the ensuing distribution with the status quo.Competition will yield winners and losers, both in terms of factor claims and in terms of regions or provinces. Income differences will press people to migrate.To analyze this, we divide China into 30 input-output sectors and 27 provinces; we maximize domestic final demand, while preserving its proportions in each province, subject to material balances and factor constraints.The shadow prices to the constraints represent competitive commodity prices and factor rewards.Unskilled labor would stand to lose and, therefore, inequality would mount.The pressure on interprovincial migration would be enormous with 10 to 20% of the people on the road.The flipside is the great potential for improvement of the average standard of living.competition;income distribution;migration
Spherical squeeze-film hybrid bearing with small steady-state radial displacement
Spherical squeeze-film hybrid bearing with small steady-state radial displacement analysi
The solution of special squeeze film gas bearing problems by an improved numerical technique
Computer program for solving squeeze film gas bearing problem
On the slowly time dependent problem of squeeze film bearings
Time dependency of spherical squeeze-film bearing for use in suspension of precision gyroscope outpu
Dynamic response of a double squeeze-film thrust plate
Dynamic response of gaseous double squeeze film thrust plate for bearing
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
BACKGROUND: Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor (EGFR) family, can contribute to the development of diabetic peripheral neuropathy (DPN). In peripheral nerves, Erb B receptors are activated by various members of the neuregulin-1 (NRG1) family including NRG1 Type I, NRG1 Type II and NRG1 Type III to regulate Schwann cell (SC) growth, migration, differentiation and dedifferentiation. Alternatively, Erb B2 activity can be negatively regulated by association with the Erb B2-interacting protein, erbin. Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the current study determined whether changes in NRG1 isoforms and erbin may be associated with altered Erb B2 signaling in DPN. RESULTS: Swiss Webster mice were rendered diabetic with streptozotocin (STZ) and after 12 weeks of diabetes, treated with erlotinib, an inhibitor of Erb B2 activation. Inhibition of Erb B2 signaling partially reversed several pathophysiologic aspects of DPN including a pronounced sensory hypoalgesia, nerve conduction velocity deficits and the decrease in epidermal nerve fiber innervation. We also observed a decrease of NRG1 Type III but an increase of NRG1 Type I level in diabetic sural nerves at early stage of diabetes. With disease progression, we detected reduced erbin expression and enhanced MAPK pathway activity in diabetic mice. Inhibition of Erb B2 receptor suppressed MAPK pathway activity in treated-diabetic sural nerves. CONCLUSIONS: These results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway. Together, imbalanced NRG1 isoforms and downregulated erbin may contribute to the dysregulation of Erb B2 signaling in the development of DPN
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