125 research outputs found
Pile Setup in Cohesive Soil. I: Experimental Investigation
Pile setup in cohesive soils has been a known phenomenon for several decades. However, a systematic field investigation to provide the needed data to develop analytical procedures and integrate pile setup into the design method rarely exists. This paper summarizes a recently completed field investigation on five fully instrumented steel H-piles embedded in cohesive soils, while a companion paper discusses the development of the pile setup method. During the field investigation, detailed soil characterization, monitoring of soil total lateral stress and pore-water pressure, collection of pile dynamic restrike data as a function of time, and vertical static load tests were completed. Restrike measurements confirm that pile setup occurs at a logarithmic rate following the end of driving, and its development correlates well with the rate of dissipation of the measured porewater pressure. Based on the field data collected, it was concluded that the skin friction component, not the end bearing, contributes predominantly to the setup, which can be accurately estimated for practical purposes using soil properties, such as coefficient of consolidation, undrained shear strength, and the standard penetration testN-value
Regularity for eigenfunctions of Schr\"odinger operators
We prove a regularity result in weighted Sobolev spaces (or
Babuska--Kondratiev spaces) for the eigenfunctions of a Schr\"odinger operator.
More precisely, let K_{a}^{m}(\mathbb{R}^{3N}) be the weighted Sobolev space
obtained by blowing up the set of singular points of the Coulomb type potential
V(x) = \sum_{1 \le j \le N} \frac{b_j}{|x_j|} + \sum_{1 \le i < j \le N}
\frac{c_{ij}}{|x_i-x_j|}, x in \mathbb{R}^{3N}, b_j, c_{ij} in \mathbb{R}. If u
in L^2(\mathbb{R}^{3N}) satisfies (-\Delta + V) u = \lambda u in distribution
sense, then u belongs to K_{a}^{m} for all m \in \mathbb{Z}_+ and all a \le 0.
Our result extends to the case when b_j and c_{ij} are suitable bounded
functions on the blown-up space. In the single-electron, multi-nuclei case, we
obtain the same result for all a<3/2.Comment: to appear in Lett. Math. Phy
Symmetries and observables in topological gravity
After a brief review of topological gravity, we present a superspace approach
to this theory. This formulation allows us to recover in a natural manner
various known results and to gain some insight into the precise relationship
between different approaches to topological gravity. Though the main focus of
our work is on the vielbein formalism, we also discuss the metric approach and
its relationship with the former formalism.Comment: 34 pages; a few explanations added in subsection 2.2.1, published
version of pape
Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues
Proteolysis-inducing factor, a cachexia-inducing tumour product, is an N-glycosylated peptide with homology to the unglycosylated neuronal survival peptide Y-P30 and a predicted product of the dermcidin gene, a pro-survival oncogene in breast cancer. We aimed to investigate whether dermcidin is pro-survival in liver cells, in which proteolysis-inducing factor induces catabolism, and to determine the role of potentially glycosylated asparagine residues in this function. Reverse cloning of proteolysis-inducing factor demonstrated âŒ100% homology with the dermcidin cDNA. This cDNA was cloned into pcDNA3.1+ and both asparagine residues removed using site-directed mutagenesis. In vitro translation demonstrated signal peptide production, but no difference in molecular weight between the products of native and mutant vectors. Immunocytochemistry of HuH7 cells transiently transfected with V5-His-tagged dermcidin confirmed targeting to the secretory pathway. Stable transfection conferred protection against oxidative stress. This was abrogated by mutation of both asparagines in combination, but not by mutation of either asparagine alone. These findings suggest that dermcidin may function as an oncogene in hepatic as well as breast cells. Glycosylation does not appear to be required, but the importance of asparagine residues suggests a role for the proteolysis-inducing factor core peptide domain
Construction of Modern Robust Nodal Discontinuous Galerkin Spectral Element Methods for the Compressible Navier-Stokes Equations
Discontinuous Galerkin (DG) methods have a long history in computational
physics and engineering to approximate solutions of partial differential
equations due to their high-order accuracy and geometric flexibility. However,
DG is not perfect and there remain some issues. Concerning robustness, DG has
undergone an extensive transformation over the past seven years into its modern
form that provides statements on solution boundedness for linear and nonlinear
problems.
This chapter takes a constructive approach to introduce a modern incarnation
of the DG spectral element method for the compressible Navier-Stokes equations
in a three-dimensional curvilinear context. The groundwork of the numerical
scheme comes from classic principles of spectral methods including polynomial
approximations and Gauss-type quadratures. We identify aliasing as one
underlying cause of the robustness issues for classical DG spectral methods.
Removing said aliasing errors requires a particular differentiation matrix and
careful discretization of the advective flux terms in the governing equations.Comment: 85 pages, 2 figures, book chapte
- âŠ