Gambaran kualitas hidup dan prestasi akademik pada siswa SMA Negeri 9 Manado di masa pandemi COVID-19

Background: Adolescents are the population who fall into the 10-19 age group and in this phase, there is rapid growth and development. High school students are individuals who belong to the youth group and their job is to learn to achieve academic achievement. The emergence of the COVID-19 outbreak resulted in students learning from home. This can affect the quality of life of adolescents. Quality of life is the perception of individuals in their lives in terms of cultural contexts, behavior and value systems and is related to the standard of living, expectations, pleasures, and individual assessments of their position in life. This study aims to describe the quality of life and academic achievement of SMA Negeri 9 Manado students during the COVID-19 pandemic. Methods: This was a descriptive study on 95 adolescents who have academic achievements.Results: The majority of adolescents have a moderate level of quality of life. Students who have higher average scores (score of 90.6-100) have a higher quality of life (physical, psychological, social, and environmental health domains) than students with lower scores (score of 74,6-90,5)Conclusion: Students of SMA Negeri 9 Manado have good academic achievements and a moderate level of quality of life. The higher academic achievement the higher the quality of life of these students.Keywords: Adolescents, quality of life, academic achievemen

Science Park Provinsi Sulawesi Utara. “Wayfinding Architecture ”

Masih kurangnya industri yang melakukan kerjasama inovasi dengan perguruan tinggi menjadi permasalahan negara Indonesia untuk mencapai visi sebagai negara maju dan sejahtera pada tahun 2025. Oleh karena itu pemerintah Indonesia berencana melakukan pengembangan SDM dan Iptek yang merupakan salah satu strategi untuk mempercepat tranformasi ekonomi. Merancang science park dan techno park untuk membantu pengembangan SDM dan Iptek. Science Park untuk wilayah provinsi sedangkan Techno Park untuk wilayah kabupaten/kota Menanggapi hal diatas pemerintah dan Bappeda Provinsi Sulawesi Utara telah merancang MasterPlan untuk Science Park Provinsi Sulawesi Utara dalam bidang pertanian dan perkebunan. Penulis tertarik untuk mengangkat sebuah judul tugas akhir perancangan Arsitektur, yaitu Science Park Provinsi Sulawesi Utara. Lokasi Perancangan Science Park ini berdasarkan master plan diatas dengan menggunakan tema Wayfinding Architecture. Pendekatan dalam rancangan objek Science Park Provinsi Sulawesi Utara mencakup 3 yaitu pendekatan tipologi objek, pendekatan tematik, pendekatan analisis tapak dan lingkungan. Penulis menggunakan proses perancangannya 5 langkah oleh James C. Synder dan Antony J. Catanese yaitu permulaan, persiapan, pengajuan judul, evaluasi, dan tindakan. Konkretisasi desain sebagai hasil dari proses perancangan diatas terdiri dari layout, denah, tampak, potongan, perspektif, dan gambar tambahan lainnya. Dimana tema Wayfinding Architecture diterapkan pada sirkulasi utama objek Science Park ini adalah sirkulasi linear yang didesain berliku dengan penerapan screen vista yang disengaja untuk menutupi gedung utama sehingga membuat pengunjung menjadi penasaran dan terpacu untuk terus menjelajahi jalur sirkulasi yang ada. Pada ruang dalam tema wayfinding architecture di terapkan pada sirkulasi yang didesain terpusat. Selain ruang luar dan ruang dalam, penerapan tema juga terhadap titik-titik keputusan (landmark, signage, vegetasi, hardscape) untuk membuat pengunjung tidak tersesat dan menemukan tujuan mereka

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides bound specifically to the enzyme insulin-regulated aminopeptidase (IRAP), which is proposed to be the site in the brain that mediates the memory effects of these peptides. However, the mechanism of action is still unknown but may involve inhibition of the aminopeptidase activity of IRAP, since both angiotensin IV and LVV-hemorphin 7 are competitive inhibitors of the enzyme. IRAP also has another functional domain that is thought to regulate the trafficking of the insulin-responsive glucose transporter GLUT4, thereby influencing glucose uptake into cells. Although the exact mechanism by which the peptides enhance memory is yet to be elucidated, IRAP still represents a promising target for the development of a new class of cognitive enhancing agents

Corrigendum: Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe (Front. Vet. Sci., (2021), 8, (688078), 10.3389/fvets.2021.688078)

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First identification of Zn 58 β -delayed proton emission

7 pags., 6 figs., 2 tabs.The β decay of Zn57 and Zn58 was investigated in an experiment at the National Superconducting Cyclotron Laboratory of Michigan State University. For the first time β-delayed proton emission from Zn58 was observed with a branching ratio of 0.7(1)%. The proton-energy spectrum allowed for probing the Gamow-Teller strength distribution above the proton-separation energy in the daughter nucleus. Moreover, the absolute branching ration for delayed-proton emission from Zn57 was found to be compatible with 100%.Operation of the NSCL was supported by the National Science Foundation under Grant PHY-1102511. This work was supported by the National Science Center, Poland, under Contract No. UMO-2015/17/B/ST2/00581, by the US Department of Energy, Office of Science, Office of Nuclear Physics, under US DOE Grants No. DE-AC05-00OR22725 (ORNL) and No. DE-FG02-96ER40983 (UTK), by the fund source National Nuclear Security Administration Grant No. DEFC03- 03NA00143, and under the Stewardship Science Academic Alliance program through DOE Cooperative Agreement No. DE-FG52-08NA28552 (UTK). A.A.C. acknowledges support by the Polish Ministry of Science and Higher Education through Grant No. 0079/DIA/2014/43 (”Grant Diamentowy”). H.S. acknowledges support by the US National Science Foundation under awards PHY-1430152 (JINA Center for the Evolution of the Elements) and PHY-1102511. P.S. acknowledges support from MCIU/AEI/FEDER_UE (Spain) under Grant No. PGC2018-093636-B-I00

Metal ion modulation of cystinyl aminopeptidase

Cystinyl aminopeptidase has one Zn(2+)-binding motif and is a member of the M1 aminopeptidase family. Ion modulation of its catalytic activity was studied in membranes of CHO-K1 cells (Chinese-hamster ovary K1 cells) using L-leucine-p-nitroanilide as substrate. The planar bidentate chelators 1,10-phenanthroline and 2,2′-bipyridine inhibited the activity in a concentration-dependent manner with Hill slopes of 3.32±1.78 and 2.10±0.26 respectively. The acetic acid-containing chelators EDTA, EGTA and DTPA (diethylenetriamine-N,N,N′,N″,N″-penta-acetic acid) weakly affected the activity, but they increased the potency of the planar chelators up to a limit, at which Hill slopes became close to unity. Moreover, competition between 1,10-phenanthroline and the substrate only took place in the presence of EDTA. These findings are compatible with a model in which the bidentate chelators inhibit enzyme activity by decreasing the free Zn(2+) concentration. By removing a modulatory ion from an allosteric site at the enzyme, the acetic acid-containing chelators facilitate the direct interaction between the bidentate chelators and the catalytic Zn(2+). The inhibitory effect of EDTA plus 1,10-phenanthroline could be completely reversed by Zn(2+). Ca(2+) and Mg(2+) increased the potency of Zn(2+) for this process. This is expected if they interact with the modulatory site to decrease the sensitivity of the enzyme towards 1,10-phenanthroline. Conversely, the bidendate chelators increased the high-affinity [(125)I]angiotensin IV binding to the membranes and this was potentiated by the acetic acid-containing chelators. These findings support the concept that high-affinity [(125)I]angiotensin IV binding, previously referred to as ‘AT(4) receptor binding’, only occurs for the cystinyl aminopeptidase apoenzyme