1,632 research outputs found

    Nepali translation, cross-cultural adaptation and measurement properties of the Shoulder Pain and Disability Index (SPADI)

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    Background: The Shoulder Pain and Disability Index (SPADI) is a 13-item shoulder-specific patient-reported outcome measure (PROM). The English version is easy to use and has demonstrated excellent measurement properties for both clinical and research settings. The availability of the SPADI in Nepali would facilitate shoulder research and enhance management of patients with shoulder pain in Nepal. Therefore, the purpose of this study was to translate and cross-culturally adapt the SPADI into Nepali (SPADI-NP) and evaluate its measurement properties. Methods: The translation and adaptation process followed international guidelines. Participants completed SPADI-NP on two assessments (N = 150 at initial and 119 at follow-up assessment). A Nepali version of the Global Rating of Change score was completed at follow-up. Assessment of measurement properties included analysis of internal consistency (Cronbach's α), minimal detectable change (MDC) with standard error of measurement (SEM), test-retest reliability (intraclass correlation coefficient; ICC), validity (factor structure, construct using Pearson's correlation with the Disability of Arm and Hand [DASH]) and responsiveness (area under the curve; AUC) with minimal important change (MIC). Results: Minor changes were integrated in the adaptation process to improve cultural relevance such as dress items. Items were largely loaded under two factors (pain and disability), internal consistencies were good for the pain construct (α = 0.82) and disability (α = 0.88) and test-retest reliability was excellent (pain = 0.89, disability = 0.96). MDC was 5.7 (out of 100) with SEM = 2.1. Strong associations with the DASH (r = 0.63 pain, r = 0.81 disability) demonstrated its construct validity. The AUC was 0.68 and MIC was 12.3 (out of 100). Conclusion: The Nepali version of the SPADI demonstrated excellent reliability and validity. It can be used for the assessment of shoulder pain and disability in patients with shoulder pain in Nepal in both clinical practice and research

    Revisiting the analytical solution approach to mixing-limited equilibrium multicomponent reactive transport using mixing ratios: identification of basis, fixing an error, and dealing with multiple minerals

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    Multicomponent reactive transport involves the solution of a system of nonlinear coupled partial differential equations. A number of methods have been developed to simplify the problem. In the case where all reactions are in instantaneous equilibrium and the mineral assemblage is constant in both space and time, de Simoni et al. (2007) provide an analytical solution that separates transport of aqueous components and minerals using scalar dissipation of Multicomponent reactive transport involves the solution of a system of nonlinear coupled partial differential equations. A number of methods have been developed to simplify the problem. In the case where all reactions are in instantaneous equilibrium and the mineral assemblage is constant in both space and time, de Simoni et al. (2007) provide an analytical solution that separates transport of aqueous components and minerals using scalar dissipation of "mixing ratios" between a number of boundary/initial solutions. In this approach, aqueous speciation is solved in conventional terms of primary and secondary species, and the mineral dissolution/precipitation rate is given in terms of the scalar dissipation and a chemical transformation term, both involving the secondary species associated with the mineral reaction. However, the identification of the secondary species is nonunique, and so it is not clear how to use the approach in general, a problem that is keenly manifest in the case of multiple minerals which may share aqueous ions. We address this problem by developing an approach to identify the secondary species required in the presence of one or multiple minerals. We also remedy a significant error in the de Simoni et al. (2007) approach. The result is a fixed and extended de Simoni et al. (2007) approach that allows construction of analytical solutions to multicomponent equilibrium reactive transport problems in which the mineral assemblage does not change in space or time and where the transport is described by closed-form solutions of the mixing ratios

    Relaxation time effects on dynamic conductivity of alloyed metallic thin films in the infrared band

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    The behavior of nanoscale infrared antenna elements depends upon the dynamic conductivity of thin metallic films. Spectroscopic ellipsometer measurements of noble metal films show that when the product of the incident radiation frequency and the relaxation time is greater than unity, anomalous dynamic electron transport effects occur. In this regime electron scattering increases the conductivity of alloyed metallic films as demonstrated by ellipsometry measurements of films from the Au-Cu system. A binary alloy thin film was fabricated with equal parts of Au and Cu, and the dynamic conductivity was measured to be 300% larger than the high frequency conductivity of pure Au or pure Cu films at wavelengths in the 3-5 mu m band. When electronic scattering is reduced, ellipsometer measurements of Au and Cu films taken near 4 K demonstrate that the IR conductivity decreases to 20% of the value measured at 300 K at wavelengths in the 3-5 mu m band. Using measured dc relaxation times, a model to explain deviations from Drude behavior was developed using the theory of the anomalous skin effect and frequency dependent relaxation time. This model was in quantitative agreement with the measured data. The ability to design an alloyed metallic thin film using a calculated ideal dc relaxation time to produce the greatest possible dynamic conductivity for infrared antennas and metamaterials was demonstrated

    Revisiting the analytical solution approach to mixing-limited equilibrium multicomponent reactive transport using mixing ratios: identification of basis, fixing an error, and dealing with multiple minerals

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    Multicomponent reactive transport involves the solution of a system of nonlinear coupled partial differential equations. A number of methods have been developed to simplify the problem. In the case where all reactions are in instantaneous equilibrium and the mineral assemblage is constant in both space and time, de Simoni et al. (2007) provide an analytical solution that separates transport of aqueous components and minerals using scalar dissipation ofPeer ReviewedPostprint (published version

    Flexible active compensation based on load conformity factors applied to non-sinusoidal and asymmetrical voltage conditions

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    This study proposes a flexible active power filter (APF) controller operating selectively to satisfy a set of desired load performance indices defined at the source side. The definition of such indices, and of the corresponding current references, is based on the orthogonal instantaneous current decomposition and conformity factors provided by the conservative power theory. This flexible approach can be applied to single- or three-phase APFs or other grid-tied converters, as those interfacing distributed generators in smart grids. The current controller is based on a modified hybrid P-type iterative learning controller which has shown good steady-state and dynamic performances. To validate the proposed approach, a three-phase four-wire APF connected to a non-linear and unbalanced load has been considered. Experimental results have been generated under ideal and non-ideal voltage sources, showing the effectiveness of the proposed flexible compensation scheme, even for weak grid scenarios

    Climate change in Hong Kong : observations and projections

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    The Hong Kong Observatory has been making meteorological observations at its headquarters in Tsim Sha Tsui since 1884. Analysis of the extensive past records reveals that the temperature rise in Hong Kong during the past 125 years is in accord with the global rising trend. In last few decades anthropogenic influences, especially urbanization, have contributed significantly to the accelerated rising trend. A similar increasing trend is also observed for rainfall but the trend after 1947 is not statistically significant. Other observations such as increasing cloud amounts, decreasing total global solar radiation and rising sea level are all consistent with the global trend. Studies of past occurrences of extreme temperature and rainfall have recently been carried out. It is observed that cold episodes have become rarer while very hot days and heavy rain events are becoming more frequent. The corresponding return periods of heavy rain and very hot days are decreasing while those of very cold days are increasing. The Observatory also makes use of the data from the latest assessment report of the Intergovernmental Panel on Climate Change and employs statistical downscaling techniques to carry out projections of temperature and precipitation in the 21st century. In gist, the findings are that the rise in temperature will be slightly higher than the global mean in the 21st century. There will also be a significant decrease in the number of cold days and an increase in the number of very hot days and hot nights. The annual rainfall in Hong Kong is also expected to rise by the end of the 21st century, so is the year-to-year variability

    Explaining Student Behavior at Scale: The Influence of Video Complexity on Student Dwelling Time

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    Understanding why and how students interact with educational videos is essential to further improve the quality of MOOCs. In this paper, we look at the complexity of videos to explain two related aspects of student behavior: the dwelling time (how much time students spend watching a video) and the dwelling rate (how much of the video they actually see). Building on a strong tradition of psycholinguistics, we formalize a definition for information complexity in videos. Furthermore, building on recent advancements in time-on-task measures we formalize dwelling time and dwelling rate based on click-stream trace data. The resulting computational model of video complexity explains 22.44% of the variance in the dwelling rate for students that finish watching a paragraph of a video. Video complexity and student dwelling show a polynomial relationship, where both low and high complexity increases dwelling. These results indicate why students spend more time watching (and possibly contemplating about) a video. Furthermore, they show that even fairly straightforward proxies of student behavior such as dwelling can already have multiple interpretations; illustrating the challenge of sense-making from learning analytics.Centre for Innovatio

    Evaluation of Microbiome-Host Relationships in the Zebrafish Gastrointestinal System Reveals Adaptive Immunity Is a Target of Bis(2-ethylhexyl) Phthalate (DEHP) Exposure

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    To improve physical characteristics of plastics such as flexibility and durability, producers enrich materials with phthalates such as di-2-(ethylhexyl) phthalate (DEHP). DEHP is a high production volume chemical associated with metabolic and immune disruption in animals and humans. To reveal mechanisms implicated in phthalate-related disruption in the gastrointestinal system, male and female zebrafish were fed DEHP (3 ppm) daily for two months. At the transcriptome level, DEHP significantly upregulated gene networks in the intestine associated with helper T cells' (Th1, Th2, and Th17) specific pathways. The activation of gene networks associated with adaptive immunity was linked to the suppression of networks for tight junction, gap junctional intercellular communication, and transmembrane transporters, all of which are precursors for impaired gut integrity and performance. On a class level, DEHP exposure increased Bacteroidia and Gammaproteobacteria and decreased Verrucomicrobiae in both the male and female gastrointestinal system. Further, in males there was a relative increase in Fusobacteriia and Betaproteobacteria and a relative decrease in Saccharibacteria. Predictive algorithms revealed that the functional shift in the microbiome community, and the metabolites they produce, act to modulate intestinal adaptive immunity. This finding suggests that the gut microbiota may contribute to the adverse effects of DEHP on the host by altering metabolites sensed by both intestinal and immune Th cells. Our results suggest that the microbiome-gut-immune axis can be modified by DEHP and emphasize the value of multiomics approaches to study microbiome-host interactions following chemical perturbations
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