Dielectric molding apparatus Patent

Dielectric apparatus for heating, fusing, and hardening of organic matrix to form plastic material into shaped produc

Vibrational Feshbach Resonances Mediated by Nondipole Positron-Molecule Interactions

Measurements of energy-resolved positron-molecule annihilation show the existence of positron binding and vibrational Feshbach resonances. The existing theory describes this phenomenon successfully for the case of infrared-active vibrational modes which allow dipole coupling between the incident positron and the vibrational motion. Presented here are measurements of positron-molecule annihilation made using a recently developed cryogenic positron beam capable of significantly improved energy resolution. The results provide evidence of resonances associated with infrared-inactive vibrational modes, indicating that positron-molecule bound states may be populated by nondipole interactions. The anticipated ingredients for a theoretical description of such interactions are discussed.Comment: 5 pages, 2 figures, Phys. Rev. Lett. (in press

Potentials for hyper-Kahler metrics with torsion

We prove that locally any hyper-K\"ahler metric with torsion admits an HKT potential.Comment: 9 page

Characterizing the metabolic phenotype of intestinal villus blunting in Zambian children with severe acute malnutrition and persistent diarrhea

Background: Environmental enteric dysfunction (EED) is widespread throughout the tropics and in children is associated with stunting and other adverse health outcomes. One of the hallmarks of EED is villus damage. In children with severe acute malnutrition (SAM) the severity of enteropathy is greater and short term mortality is high, but the metabolic consequences of enteropathy are unknown. Here, we characterize the urinary metabolic alterations associated with villus health, classic enteropathy biomarkers and anthropometric measurements in severely malnourished children in Zambia. Methods/Principal findings: We analysed 20 hospitalised children with acute malnutrition aged 6 to 23 months in Zambia. Small intestinal biopsies were assessed histologically (n = 15), anthropometric and gut function measurements were collected and the metabolic phenotypes were characterized by 1H nuclear magnetic resonance (NMR) spectroscopy. Endoscopy could not be performed on community controls children. Growth parameters were inversely correlated with enteropathy biomarkers (p = 0.011) and parameters of villus health were inversely correlated with translocation and permeability biomarkers (p = 0.000 and p = 0.015). Shorter villus height was associated with reduced abundance of metabolites related to gut microbial metabolism, energy and muscle metabolism (p = 0.034). Villus blunting was also related to increased sucrose excretion (p = 0.013). Conclusions/Significance: Intestinal villus blunting is associated with several metabolic perturbations in hospitalized children with severe undernutrition. Such alterations include altered muscle metabolism, reinforcing the link between EED and growth faltering, and a disruption in the biochemical exchange between the gut microbiota and host. These findings extend our understanding on the downstream consequences of villus blunting and provide novel non-invasive biomarkers of enteropathy dysfunction. The major limitations of this study are the lack of comparative control group and gut microbiota characterization

Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice

The hydrolysis of xenobiotic glucuronides by gut bacterial glucuronidases reactivates previously detoxified compounds resulting in severe gut toxicity for the host. Selective bacterial β-glucuronidase inhibitors can mitigate this toxicity but their impact on wider host metabolic processes has not been studied. To investigate this the inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine (UNC10201652, Inh 9) was administered to mice to selectively inhibit a narrow range of bacterial β-glucuronidases in the gut. The metabolomic profiles of the intestinal contents, biofluids, and several tissues involved in the enterohepatic circulation were measured and compared to control animals. No biochemical perturbations were observed in the plasma, liver or gall bladder. In contrast, the metabolite profiles of urine, colon contents, feces and gut wall were altered compared to the controls. Changes were largely restricted to compounds derived from gut microbial metabolism. This work establishes that inhibitors targeted towards bacterial β-glucuronidases modulate the functionality of the intestinal microbiota without adversely impacting the host metabolic system

Tip Reporting In Independent Food And Beverage Establishments

Tip reporting has always been an issue for the IRS. What happens when individuals under-report their tip income? History has shown that a large burden is placed upon the restaurants for the additional taxes that are lost due to unreported tip income. Using focus group interviews and survey research, this study addresses four research questions: 1. Do restaurant employers understand the tip reporting requirements? ; 2. Where does the IRS place the burden of record keeping and payment of lost taxes? ; 3. Are restaurants aware of the tip reporting resources available to them? ; 4. What are the implications of under-reporting tip income

Closed forms and multi-moment maps

We extend the notion of multi-moment map to geometries defined by closed forms of arbitrary degree. We give fundamental existence and uniqueness results and discuss a number of essential examples, including geometries related to special holonomy. For forms of degree four, multi-moment maps are guaranteed to exist and are unique when the symmetry group is (3,4)-trivial, meaning that the group is connected and the third and fourth Lie algebra Betti numbers vanish. We give a structural description of some classes of (3,4)-trivial algebras and provide a number of examples.Comment: 36 page

The Effect of Moxidectin Treatment on the Equine Hind Gut Microbiome, Metabonome and Feed Fermentation Kinetics in Horses with Very Low Parasite Burdens

Seventeen horses, mean 12 ± 3.5 years, kept at pasture, with haylage provided and no concentrates. Faecal Egg Counts were conducted September 2015‐March 2016, no eggs seen, no anthelmintic given. Sampling commenced March 2016, points were 0 (prior), 16, 48 and 168 hours post anthelmintic. Treatments were randomized, nine animals dosed orally with Moxidectin 18.92 mg/g at 0.4 mg/kg bw and eight controls. Three horses from each group were randomly assigned for fermentation kinetics. Sequencing of the 16S rRNA gene was conducted on extracted faecal bacterial DNA, bioinformatics using QIIME assigning operational taxonomic units (OTUs). LEfSe (Segata et al., 2011) was used to identify differentially abundant OTUs. Bacterial metabolic profiles were characterized by 1H NMR spectroscopy (Escalona et al., 2015), from urine, analysed by Principal Components Analysis. Fermentation of hay and oats, separately, were measured by in vitro gas production (Murray et al., 2006), data were analysed by repeated measures ANOVA

Athlete Perceptions of Flavored, Menthol-enhanced Energy Gels Ingested Prior to Running in the Heat

Thermal perception during exercise is known to influence endurance performance and the onset of fatigue. L-menthol, an organic compound derived from peppermint, evokes a cooling sensation through its action on TRPM8 channels which also respond to cold stimuli. Recent work identified that the internal application of menthol-enhanced fluids can be ergogenic during exercise in the heat. Hence, the addition of menthol to energy gels may be practical and beneficial for athletes. PURPOSE: To determine athlete acceptability and preferences for flavored energy gels with different menthol concentrations. METHODS: With a randomized, crossover, and double-blind placebo-controlled design, 27 endurance athletes (34.8±6.7 y, BMI: 21.7±1.6 kg·m-2, 9 female) ingested an energy gel with a menthol additive at relative concentrations: low (0.1%), medium-low (0.3%), medium-high (0.5%), high (0.7%), or a non-menthol, flavor-matched placebo (CON), on separate days before outdoor running sessions. Athletes rated the gels for cooling sensation, irritation (tingling/burning), flavor, and overall experience on 100-point sensory and hedonic labeled magnitude scales. The duration of any cooling sensation was also reported. Repeated measures ANOVAs with a Bonferroni adjustment for pairwise comparisons were used to determine differences. RESULTS: All menthol gels successfully delivered a greater cooling sensation compared to CON (7.4±8.1 AU) with a significantly greater response for 0.7% (59.9±20.5 AU) and 0.5% (57.7±21.8 AU), compared to all others, which were both rated “moderate-strong” for intensity. Irritation intensity was higher for all menthol gels compared to CON (3.4±7.2 AU), and for 0.7% compared to 0.1% (31.1±31.0 vs 16.3±21.0 AU, p=0.041), with none reported higher than a “mild-moderate” intensity. The menthol gels delivered a significantly longer cooling duration (range: 12.3-19.6 min) compared to CON (2.2±4.8 min) with no significant difference between menthol gels. Ratings of overall experience and flavor were not different between gels (p\u3e.05). CONCLUSION: A flavored energy gel with the addition of menthol at 0.1-0.7% provides a cooling sensation for athletes when ingested before exercise. The 0.5% concentration is recommended to maximize the cooling sensation of the gel whilst minimizing irritation