ScotRail and Adopt A Station: the indirect benefits of community involvement in public transport spaces

In recent years the customer role has evolved from a passive recipient of services to a proactive cocreator in the activities of an organisation Customers are increasingly viewed as a resource with firms increasing collaboration to increase benefits to both parties. Cocreation activity can offer improved predictability and quality in the exchange for the firm and feelings of self-efficacy, enjoyment and psychological benefits for customers. Research exploring cocreation focuses mainly on direct relationships between a firm and it’s customers and the benefits accrued therein. Little attention has explored the extent to which collaborative activities might have an indirect effect on parties not directly involved in the process. This paper is based on a doctoral study which measured how value cocreation within a public transport setting can offer both direct and indirect benefits to users

Fast nuclear staining of head hair roots as a screening method for successful STR analysis in forensics

The success rate of STR profiling of hairs found at a crime scene is quite low and negative results of hair analysis are frequently reported. To increase the success rate of DNA analysis of hairs in forensics, nuclei in hair roots can be counted after staining the hair root with DAPI. Two staining methods were tested: a longer method with two 1 h incubations in respectively a DAPI-and a wash-solution, and a fast, direct staining of the hair root on microscope slides. The two staining methods were not significantly different. The results of the STR analysis for both procedures showed that 20 nuclei are necessary to obtain at least partial STR profiles. When more than 50 nuclei were counted, full STR profiles were always obtained. In 96% of the cases where no nuclei were detected, no STR profile could be obtained. However, 4% of the DAPI-negative hair roots resulted in at least partial STR profiles. Therefore, each forensic case has to be evaluated separately in function of the importance of the evidential value of the found hair. The fast staining method was applied in 36 forensic cases on 279 hairs in total. A fast screening method using DAPI can be used to increase the success rate of hair analysis in forensics

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice

OBJECTIVE: Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal monitoring of disease development. This study was undertaken to determine whether gait can be used to measure disease severity in the STR/Ort mouse model of spontaneous OA and whether gait changes are related to OA joint pain. METHODS: Gait was monitored using a treadmill-based video system. Correlations between OA severity and gait at 3 treadmill speeds were assessed in STR/Ort mice. Gait and pain behaviors of STR/Ort mice and control CBA mice were analyzed longitudinally, with monthly assessments. RESULTS: The best speed to identify paw area changes associated with OA severity in STR/Ort mice was found to be 17 cm · seconds(−1). Paw area was modified with age in CBA and STR/Ort mice, but this began earlier in STR/Ort mice and correlated with the onset of OA at 20 weeks of age. In addition, task noncompliance appeared at 20 weeks. Surprisingly, STR/Ort mice did not show any signs of pain with OA development, even when treated with the opioid antagonist naloxone, but did exhibit normal pain behaviors in response to complete Freund's adjuvant–induced arthritis. CONCLUSION: The present results identify an animal model in which OA severity and OA pain can be studied in isolation from one another. The findings suggest that paw area and treadmill noncompliance may be useful tools to longitudinally monitor nonpainful OA development in STR/Ort mice. This will help in providing a noninvasive means of assessing new therapies to slow the progression of OA

A reference haplotype panel for genome-wide imputation of short tandem repeats.

Short tandem repeats (STRs) are involved in dozens of Mendelian disorders and have been implicated in complex traits. However, genotyping arrays used in genome-wide association studies focus on single nucleotide polymorphisms (SNPs) and do not readily allow identification of STR associations. We leverage next-generation sequencing (NGS) from 479 families to create a SNP + STR reference haplotype panel. Our panel enables imputing STR genotypes into SNP array data when NGS is not available for directly genotyping STRs. Imputed genotypes achieve mean concordance of 97% with observed genotypes in an external dataset compared to 71% expected under a naive model. Performance varies widely across STRs, with near perfect concordance at bi-allelic STRs vs. 70% at highly polymorphic repeats. Imputation increases power over individual SNPs to detect STR associations with gene expression. Imputing STRs into existing SNP datasets will enable the first large-scale STR association studies across a range of complex traits

Quantum corrections to broken N = 8 supergravity

We show that the one-loop effective potential of spontaneously broken N=8 supergravity is calculable and finite at all classical four-dimensional Minkowski vacua without tachyons in the spectrum. The reason is that the supertraces of the quadratic and quartic mass matrices vanish along the classically flat directions: Str M^2 = Str M^4 =0. We also show that Str M^6 = 0 but Str M^8 > 0 in a broad class of vacua with broken supersymmetry on a flat background, which includes all those explicitly identified so far. We find analytical and numerical evidence that the corresponding one-loop effective potential is negative-definite.Comment: 30 pages. v2: few misprints corrected. v3: JHEP published versio

Population genetic data for 17 Y STR markers from Benghazi (East Libya)

The seventeen Y-STR loci included in the AmpF‘STR1 YfilerTM PCR Amplification kit (DYS19, DYS389I,DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS438, DYS439, DYS437, DYS448, DYS458,DYS456, DYS635, and Y-GATA-H4) were used to type a sample population of 238 males from eastern Libya (Benghazi region). Of 238 observed haplotypes, 214 were unique (90%) and 24 (10%) were found more than once. The 17 loci gave a discriminating power of 0.999. DYS458 showed the highest diversity as a single-locus marker (0.73). Allelic frequencies and gene diversities for each Y-STR locus were determined. The high haplotype diversity and discrimination capacity (0.996) demonstrate the utility of these loci for human identification in forensic applications. Comparative analysis with Y-STR datasets of relevant populations and submission of the haplotypes to the Y-STR Haplotype Reference Database (YHRD) was undertaken

Vanishing Str M^2 in the presence of anomalous U_A(1)

We show that the presence of an anomalous $\rm U_A(1)$ factor in the gauge group of string-derived models may have the new and important phenomenological consequence of allowing the vanishing of ${\rm Str}\,{\cal M}^2$ in the ``shifted" vacuum, that results in the process of cancelling the anomalous $\rm U_A(1)$. The feasibility of this effect seems to be enhanced by a vanishing vacuum energy, and by a ``small" value of ${\rm Str}\,{\cal M}^2$ in the original vacuum. In the class of free-fermionic models with vanishing vacuum energy that we focus on, a necessary condition for this mechanism to be effective is that ${\rm Str}\,{\cal M}^2>0$ in the original vacuum. A vanishing ${\rm Str}\,{\cal M}^2$ ameliorates the cosmological constant problem and is a necessary element in the stability of the no-scale mechanism.Comment: 7 pages, no figures, LaTe

Improving Retrieval Results with discipline-specific Query Expansion

Choosing the right terms to describe an information need is becoming more difficult as the amount of available information increases. Search-Term-Recommendation (STR) systems can help to overcome these problems. This paper evaluates the benefits that may be gained from the use of STRs in Query Expansion (QE). We create 17 STRs, 16 based on specific disciplines and one giving general recommendations, and compare the retrieval performance of these STRs. The main findings are: (1) QE with specific STRs leads to significantly better results than QE with a general STR, (2) QE with specific STRs selected by a heuristic mechanism of topic classification leads to better results than the general STR, however (3) selecting the best matching specific STR in an automatic way is a major challenge of this process.Comment: 6 pages; to be published in Proceedings of Theory and Practice of Digital Libraries 2012 (TPDL 2012